Tacalcitol

Product Name: Tacalcitol
CAS No.: 57333-96-7
Chemical Name: Tacalcitol
Synonyms: TV 02;C12919;Bonalfa;PRI 2191;Tacalcital;Tacalcitol;Curatoderm;Tacalcitol RS;trans-Calcitriol;1α,24R-Dihydroxyvitamin D3
CBNumber: CB4875440
Molecular Formula: C27H44O3
Formula Weight: 416.64
MOL File: 57333-96-7.mol

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Tacalcitol Property

Boiling point:: 565.0±50.0 °C(Predicted)
Density: 1.06
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: 20mg/mL in DMSO, 20mg/mL in DMF, 20mg/mL in Ethanol
pka: 14.43±0.40(Predicted)
form: Powder
CAS DataBase Reference: 57333-96-7(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00579
Product name: Tacalcitol
Purity: ≥99% (HPLC)
Packaging: 1MG
Price: $309
Updated: 2024/03/01

Cayman Chemical

Product number: 12079
Product name: 1,24-dihydroxy Vitamin D3
Purity: ≥98%
Packaging: 1mg
Price: $169
Updated: 2021/12/16

Cayman Chemical

Product number: 12079
Product name: 1,24-dihydroxy Vitamin D3
Purity: ≥98%
Packaging: 500μg
Price: $89
Updated: 2021/12/16

Cayman Chemical

Product number: 12079
Product name: 1,24-dihydroxy Vitamin D3
Purity: ≥98%
Packaging: 5mg
Price: $712
Updated: 2021/12/16

TRC

Product number: T004005
Product name: Tacalcitol
Packaging: 1mg
Price: $320
Updated: 2021/12/16

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Tacalcitol Chemical Properties,Usage,Production

Description

Tacalcitol, the second vitamin D analog developed as a topical antipsoriatic, was introduced for keratosis, psoriasis, ichthyosis, pityriasis rubra pilaris and palmoplantar pustulosis and keratoderma. It shows improvement in appearance of skin lesions for psoriasis patients without significant side effects. In patients with psoriasis vulgaris, it effectively inhibits keratinocyte growth. Some in vitro studies have shown that tacalcitol inhibits interleukin-1-α-induced granulocyte macrophage colony-stimulating-factor mRNA expression of the human dermal microvascular endothelial cells, which may be involved in mediation of angioproliferation in skin inflammation.

Originator

Teijin (Japan)

Uses

Tacalcitol is a synthetic vitamin D3 analog.

Definition

ChEBI: Tacalcitol is a hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp. It has a role as an antipsoriatic, a vitamin D receptor agonist and an antineoplastic agent. It is a member of D3 vitamins, a hydroxy seco-steroid, a secondary alcohol and a seco-cholestane. It is functionally related to a calciol.

brand name

Bonalfa

Safety Profile

A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors,

Tacalcitol Preparation Products And Raw materials

Raw materials

CALCIUM HYDRIDE Argon Silica gel Potassium tert-butoxide 3-Chloroperoxybenzoic acid Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

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Tacalcitol Suppliers

China 100 Europe 2 Germany 1 India 2 United Kingdom 2 United States 21 Global 128

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Shandong Yizhi Medical Technology Co., LTD

Tel: 13287715206
Email: 2786175817@qq.com
Country: China
ProdList: 43
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 253
Advantage: 61

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

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View Lastest Price from Tacalcitol manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Tacalcitol 57333-96-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.0%min. HPLC
Supply Ability: 1000kg
Release date: 2022-11-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tacalcitol 57333-96-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tacalcitol 57333-96-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

57333-96-7, TacalcitolRelated Search:

Tacalcitol monohydrate 1,2-DIMETHYLENE-CYCLOHEXANE VitaMin D4 Tacalcitol

(1α，3β-5Z，7E，24R)-9，10-Secoholesta-5，7，10(19)-triene-1，3，24-triol

lα，24-Dihydroxycholecalciferol

lα，24R-Dihy-droxyvitamin D3

[5Z,7E,24R,(+)]-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,24-triol

1α,24(R)-Dihydroxyvitamin D3

1α,24R-Dihydroxyvitamin D3

(1a,3b,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol

C12919

(1α,3β,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol

Tacalcital

1α,24(R)-Dihydroxycholecalciferol

4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol

Tacalcitol

1-alpha-3-beta-5E,7E,24R)-9,10-Secocholesta-5,7,10,19-triene-1,3,24-triol

trans-Calcitriol

1a,24(R)-Dihydroxycholecalciferol

1a,24(R)-Dihydroxyvitamin D3

1a,24R-Dihydroxyvitamin D3

9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, (1a,3b,5Z,7E,24R)- (9CI)

Bonalfa

Curatoderm

PRI 2191

TV 02

1ALPHA,24(R)-DIHYDROXYVITAMIND3

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

Tacalcitol (1,24(R)-Dihydroxyvitamin D3

Tacalcitol RS

1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-

(1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R)-5-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

TacalcitolQ: What is Tacalcitol Q: What is the CAS Number of Tacalcitol Q: What is the storage condition of Tacalcitol Q: What are the applications of Tacalcitol

Tacalcitol(1,24-dihydroxy Vitamin D3)

57333-96-7

Vitamin D3 analogs