ChemicalBook > CAS DataBase List > Tacalcitol

Tacalcitol

Product Name
Tacalcitol
CAS No.
57333-96-7
Chemical Name
Tacalcitol
Synonyms
TV 02;C12919;Bonalfa;PRI 2191;Tacalcital;Tacalcitol;Curatoderm;Tacalcitol RS;trans-Calcitriol;1α,24R-Dihydroxyvitamin D3
CBNumber
CB4875440
Molecular Formula
C27H44O3
Formula Weight
416.64
MOL File
57333-96-7.mol
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Tacalcitol Property

Boiling point:
565.0±50.0 °C(Predicted)
Density 
1.06
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
20mg/mL in DMSO, 20mg/mL in DMF, 20mg/mL in Ethanol
pka
14.43±0.40(Predicted)
form 
Powder
CAS DataBase Reference
57333-96-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00579
Product name
Tacalcitol
Purity
≥99% (HPLC)
Packaging
1MG
Price
$309
Updated
2024/03/01
Cayman Chemical
Product number
12079
Product name
1,24-dihydroxy Vitamin D3
Purity
≥98%
Packaging
1mg
Price
$169
Updated
2021/12/16
Cayman Chemical
Product number
12079
Product name
1,24-dihydroxy Vitamin D3
Purity
≥98%
Packaging
500μg
Price
$89
Updated
2021/12/16
Cayman Chemical
Product number
12079
Product name
1,24-dihydroxy Vitamin D3
Purity
≥98%
Packaging
5mg
Price
$712
Updated
2021/12/16
TRC
Product number
T004005
Product name
Tacalcitol
Packaging
1mg
Price
$320
Updated
2021/12/16
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Tacalcitol Chemical Properties,Usage,Production

Description

Tacalcitol, the second vitamin D analog developed as a topical antipsoriatic, was introduced for keratosis, psoriasis, ichthyosis, pityriasis rubra pilaris and palmoplantar pustulosis and keratoderma. It shows improvement in appearance of skin lesions for psoriasis patients without significant side effects. In patients with psoriasis vulgaris, it effectively inhibits keratinocyte growth. Some in vitro studies have shown that tacalcitol inhibits interleukin-1-α-induced granulocyte macrophage colony-stimulating-factor mRNA expression of the human dermal microvascular endothelial cells, which may be involved in mediation of angioproliferation in skin inflammation.

Originator

Teijin (Japan)

Uses

Tacalcitol is a synthetic vitamin D3 analog.

Definition

ChEBI: Tacalcitol is a hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp. It has a role as an antipsoriatic, a vitamin D receptor agonist and an antineoplastic agent. It is a member of D3 vitamins, a hydroxy seco-steroid, a secondary alcohol and a seco-cholestane. It is functionally related to a calciol.

brand name

Bonalfa

Safety Profile

A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors,

Tacalcitol Preparation Products And Raw materials

Raw materials

CALCIUM HYDRIDE Argon Silica gel Potassium tert-butoxide 3-Chloroperoxybenzoic acid Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

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Tacalcitol Suppliers

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View Lastest Price from Tacalcitol manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Tacalcitol 57333-96-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0%min. HPLC
Supply Ability
1000kg
Release date
2022-11-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tacalcitol 57333-96-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tacalcitol 57333-96-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

57333-96-7, TacalcitolRelated Search:

Tacalcitol monohydrate 1,2-DIMETHYLENE-CYCLOHEXANE VitaMin D4 Tacalcitol

  • (1α，3β-5Z，7E，24R)-9，10-Secoholesta-5，7，10(19)-triene-1，3，24-triol
  • lα，24-Dihydroxycholecalciferol
  • lα，24R-Dihy-droxyvitamin D3
  • [5Z,7E,24R,(+)]-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,24-triol
  • 1α,24(R)-Dihydroxyvitamin D3
  • 1α,24R-Dihydroxyvitamin D3
  • (1a,3b,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol
  • C12919
  • (1α,3β,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol
  • Tacalcital
  • 1α,24(R)-Dihydroxycholecalciferol
  • 4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol
  • Tacalcitol
  • 1-alpha-3-beta-5E,7E,24R)-9,10-Secocholesta-5,7,10,19-triene-1,3,24-triol
  • trans-Calcitriol
  • 1a,24(R)-Dihydroxycholecalciferol
  • 1a,24(R)-Dihydroxyvitamin D3
  • 1a,24R-Dihydroxyvitamin D3
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, (1a,3b,5Z,7E,24R)- (9CI)
  • Bonalfa
  • Curatoderm
  • PRI 2191
  • TV 02
  • 1ALPHA,24(R)-DIHYDROXYVITAMIND3
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  • Tacalcitol (1,24(R)-Dihydroxyvitamin D3
  • Tacalcitol RS
  • 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
  • (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R)-5-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
  • TacalcitolQ: What is Tacalcitol Q: What is the CAS Number of Tacalcitol Q: What is the storage condition of Tacalcitol Q: What are the applications of Tacalcitol
  • Tacalcitol(1,24-dihydroxy Vitamin D3)
  • 57333-96-7
  • Vitamin D3 analogs