4-Chloro-2-(methylsulfonyl)pyrimidine
Uses- Product Name
- 4-Chloro-2-(methylsulfonyl)pyrimidine
- CAS No.
- 97229-11-3
- Chemical Name
- 4-Chloro-2-(methylsulfonyl)pyrimidine
- Synonyms
- CMSP;KML-16;4-Chloro-2-(methylsulfonyl);4-Chloro-2-(methylsulfonyl)pyrimidine;4-CHLORO-2-METHANESULFONYL-PYRIMIDINE;PyriMidine, 4-chloro-2-(Methylsulfonyl)-;4-Chloro-2-(methylsulfonyl)pyrimidine ,98%
- CBNumber
- CB6663126
- Molecular Formula
- C5H5ClN2O2S
- Formula Weight
- 192.62
- MOL File
- 97229-11-3.mol
4-Chloro-2-(methylsulfonyl)pyrimidine Property
- Melting point:
- 87-89 °C
- Boiling point:
- 371.2±34.0 °C(Predicted)
- Density
- 1.486
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.77±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H5ClN2O2S/c1-11(9,10)5-7-3-2-4(6)8-5/h2-3H,1H3
- InChIKey
- BWVZLXTZQHILRC-UHFFFAOYSA-N
- SMILES
- C1(S(C)(=O)=O)=NC=CC(Cl)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- C994368
- Product name
- 4-Chloro-2-(methylsulfonyl)pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC142333
- Product name
- 4-Chloro-2-(methylsulfonyl)pyrimidine
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC142333
- Product name
- 4-Chloro-2-(methylsulfonyl)pyrimidine
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- JK277795
- Product name
- 4-Chloro-2-(methylsulfonyl)pyrimidine
- Purity
- 98%
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- FC142333
- Product name
- 4-Chloro-2-(methylsulfonyl)pyrimidine
- Packaging
- 2g
- Price
- $171
- Updated
- 2021/12/16
4-Chloro-2-(methylsulfonyl)pyrimidine Chemical Properties,Usage,Production
Uses
4-Chloro-2-methanesulfonylpyrimidine is a pyrimidine heterocyclic compound with high reactivity and broad application prospects in the fields of medicine, pesticides, dyes and pigments, and materials science.
Chemical Properties
White solid
Synthesis
49844-90-8
97229-11-3
General procedure for the synthesis of 4-chloro-2-(methylsulfonyl)pyrimidine from 2-methylthio-4-chloropyrimidine: 2-methylthio-4-chloropyrimidine (7.25 mL, 62.3 mmol) and 95% ethanol (100 mL) were added to a 250-mL single-necked flask, and the mixture was cooled to 0 °C under magnetic stirring. 30% hydrogen peroxide (14.4 mL, 187 mmol) and ammonium molybdate tetrahydrate (2.18 g, 1.87 mmol) were slowly added dropwise. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirred overnight under nitrogen protection. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure, followed by evaporation with the addition of water (200 mL). The resulting product was dried with anhydrous sodium sulfate, filtered and concentrated, and finally purified by silica gel column chromatography to give 10.2 g of white solid product in 85.7% yield.
References
[1] Organic Letters, 2011, vol. 13, # 19, p. 5000 - 5003
[2] Journal of Organic Chemistry, 2003, vol. 68, # 13, p. 5388 - 5391
[3] Patent: CN108947974, 2018, A. Location in patent: Paragraph 0122; 0125; 0127-0129
[4] Heterocycles, 1985, vol. 23, # 3, p. 611 - 616
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1146 - 1157
4-Chloro-2-(methylsulfonyl)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-2-(methylsulfonyl)pyrimidine manufacturers
- Product
- 4-Chloro-2-(methylsulfonyl)pyrimidine 97229-11-3
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-12
- Product
- 4-Chloro-2-(methylsulfonyl)pyrimidine 97229-11-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- CMSP 97229-11-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11