4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- Product Name
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- CAS No.
- 4489-34-3
- Chemical Name
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- Synonyms
- DLMSP;nsc 45040;VITAS-BB TBB000242;4,6-dichloro-2-mesyl-pyrimidine;(benzenesulfonylthio)sulfonylbenzene;6-Dichloro-2-MethylsulfonylpyriMidine;4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE;4,6-DICHLORO-2-METHANESULFONYLPYRIMIDINE;2-(methylsulfonyl)-4,6-dichloropyrimidine;4,6-DICHLORO-2-(METHYLSULFONYL)PYRIMIDINE
- CBNumber
- CB6667492
- Molecular Formula
- C5H4Cl2N2O2S
- Formula Weight
- 227.07
- MOL File
- 4489-34-3.mol
4,6-Dichloro-2-(methylsulfonyl)pyrimidine Property
- Melting point:
- 117-118°C
- Boiling point:
- 402.3±48.0 °C(Predicted)
- Density
- 1.604
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -9.08±0.30(Predicted)
- color
- White to Yellow to Orange
- InChI
- InChI=1S/C5H4Cl2N2O2S/c1-12(10,11)5-8-3(6)2-4(7)9-5/h2H,1H3
- InChIKey
- DROUVIKCNOHKBA-UHFFFAOYSA-N
- SMILES
- C1(S(C)(=O)=O)=NC(Cl)=CC(Cl)=N1
- CAS DataBase Reference
- 4489-34-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
H351Suspected of causing cancer
H371May cause damage to organs
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D4135
- Product name
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- D4135
- Product name
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- 296032
- Product name
- 4,6-Dichloro-2-methylsulfonylpyrimidine
- Packaging
- 5g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- D474448
- Product name
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 44858
- Product name
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 5G
- Price
- $75.86
- Updated
- 2021/12/16
4,6-Dichloro-2-(methylsulfonyl)pyrimidine Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
6299-25-8
4489-34-3
The general procedure for the synthesis of 4,6-dichloro-2-(methylsulfonyl)pyrimidines from 4,6-dichloro-2-methylthioalkylpyrimidines is as follows: Example 27: Synthesis of 4,6-dichloro-2-(methylsulfonyl)pyrimidine Commercially available 4,6-dichloro-2-methylsulfanylpyrimidine (Aldrich, 21.0 g, 107.0 mmol, 1 eq.) was dissolved in dichloromethane and cooled in an ice bath. Subsequently, 3-chloroperoxybenzoic acid (60.0 g, 77% wt, 268.0 mmol, 2.5 eq.) was added in batches. The resulting white suspension was stirred at room temperature for 4 hours. Upon completion of the reaction, it was washed sequentially with a mixture of 1 M sodium thiosulfate solution and saturated sodium bicarbonate solution (1:1, v/v, 200 mL x 3), saturated sodium bicarbonate solution (100 mL x 3) and brine (100 mL x 1). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The product was dried under high vacuum overnight to give the title compound EPO27 as a white solid (22.0 g, 91% yield). Thin layer chromatography Rf value was 0.20 (unfolding agent: 20% ethyl acetate/hexane); mass spectrum m/z 227 (calculated value 227, corresponding to molecular formula C5H4Cl2N2O2S+).
References
[1] Patent: WO2007/14250, 2007, A2. Location in patent: Page/Page column 17-18
[2] Patent: WO2007/87245, 2007, A2. Location in patent: Page/Page column 27
[3] Patent: WO2007/87246, 2007, A2. Location in patent: Page/Page column 27
[4] Patent: WO2008/13807, 2008, A2. Location in patent: Page/Page column 6
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 28, p. 8153 - 8157
4,6-Dichloro-2-(methylsulfonyl)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-Dichloro-2-(methylsulfonyl)pyrimidine manufacturers
- Product
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine 4489-34-3
- Price
- US $100.00-50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-12
- Product
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine 4489-34-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2021-05-21
- Product
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine 4489-34-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14