ChemicalBook > CAS DataBase List > 3-Methyl-2-nitrobenzoic acid

3-Methyl-2-nitrobenzoic acid

Product Name
3-Methyl-2-nitrobenzoic acid
CAS No.
5437-38-7
Chemical Name
3-Methyl-2-nitrobenzoic acid
Synonyms
2-NITRO-M-TOLUIC ACID;2-NITRO-3-METHYLBENZOIC ACID;BL-ME-0;3-Methyl-2-n;Fluralaner-028;RSYY(Apremilast)-19;3-Methyl-2-nitrobenz;-2-nitrobenzoic acid;Fluralaner Impurity 49;3-Methyl-2-nitrobenzoic
CBNumber
CB9223457
Molecular Formula
C8H7NO4
Formula Weight
181.15
MOL File
5437-38-7.mol
More
Less

3-Methyl-2-nitrobenzoic acid Property

Melting point:
220-223 °C (lit.)
Boiling point:
314.24°C (rough estimate)
Density 
1.4283 (rough estimate)
refractive index 
1.5468 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.26±0.10(Predicted)
color 
White to Almost white
Water Solubility 
<0.1 g/100 mL at 22 ºC
BRN 
1960698
InChI
InChI=1S/C8H7NO4/c1-5-3-2-4-6(8(10)11)7(5)9(12)13/h2-4H,1H3,(H,10,11)
InChIKey
DGDAVTPQCQXLGU-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference
5437-38-7(CAS DataBase Reference)
EPA Substance Registry System
3-Methyl-2-nitrobenzoic acid (5437-38-7)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39-22-37
WGK Germany 
3
TSCA 
Yes
HS Code 
29163990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M60406
Product name
3-Methyl-2-nitrobenzoic acid
Purity
98%
Packaging
25g
Price
$30.5
Updated
2023/06/20
Sigma-Aldrich
Product number
M60406
Product name
3-Methyl-2-nitrobenzoic acid
Purity
98%
Packaging
100g
Price
$64
Updated
2023/06/20
TCI Chemical
Product number
M1370
Product name
3-Methyl-2-nitrobenzoic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$63
Updated
2024/03/01
TCI Chemical
Product number
M1370
Product name
3-Methyl-2-nitrobenzoic Acid
Purity
>98.0%(T)
Packaging
250g
Price
$316
Updated
2024/03/01
Alfa Aesar
Product number
B25682
Product name
3-Methyl-2-nitrobenzoic acid, 98%
Packaging
25g
Price
$52.65
Updated
2024/03/01
More
Less

3-Methyl-2-nitrobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

2-Nitro-m-toluic Acid, is a building block used for the synthesis of various compounds. It can be used for the synthesis of novel Indolin-2-one derivatives as protein tyrosine phosphatase 1B inhibitors.

General Description

Prisms or white crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3-Methyl-2-nitrobenzoic acid is a nitrated carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.

Fire Hazard

Information concerning the flash point of 3-Methyl-2-nitrobenzoic acid is not available. 3-Methyl-2-nitrobenzoic acid is probably combustible.

Purification Methods

Recrystallise it from EtOH. The methyl ester has m 74o (from MeOH), and the amide [60310-07-8] M 180.1, has m 192o (needles from H2O, prisms from EtOH). [Beilstein 9 H 480, 9 IV 1722.]

3-Methyl-2-nitrobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Methyl-2-nitrobenzoic acid Suppliers

Taizhou Hongxing Chemical Co., Ltd.
Tel
18652720389
Email
liusiyuan@hxchemical.cn
Country
China
ProdList
33
Advantage
58
Henan Lingbei Biotechnology Co., Ltd
Tel
86-18539896799 18539896799
Email
71889632@qq.com
Country
China
ProdList
116
Advantage
58
Hengshui Rayson Chemical Technology Co. , Ltd.
Tel
0318-8888981 13785822979
Email
1532555757@qq.com
Country
China
ProdList
25
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
More
Less

View Lastest Price from 3-Methyl-2-nitrobenzoic acid manufacturers

Yancheng Green Chemicals Co.,Ltd
Product
3-Methyl-2-nitrobenzoic acid 5437-38-7
Price
US $0.00/Kg/Bag
Min. Order
25KG
Purity
98%
Supply Ability
200tons
Release date
2020-07-20
Asia Chem I and E (Jiangsu) Co Ltd
Product
3-Methyl-2-nitrobenzoic acid 5437-38-7
Price
US $20.93/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.50%HPLC
Supply Ability
60tons/month
Release date
2021-09-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Methyl-2-nitrobenzoic acid 5437-38-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kg
Release date
2021-09-30

5437-38-7, 3-Methyl-2-nitrobenzoic acidRelated Search:


  • 3-METHYL-2-NITROBENZOIC ACID
  • 2-NITRO-3-METHYLBENZOIC ACID
  • 2-NITRO-M-TOLUIC ACID
  • BL-ME-0
  • 3-Methyl-2-NitrobenzoicAcid98%
  • 3-Methyl-2-Nitrobenzoic Acid 98%
  • 3-Methyl-2-nitrobenzoic
  • 3-Methyl-2-nitrobenz
  • 3-Methyl-2-nitrobenzoic acid, 98% 25GR
  • 3-METHY-2-NITROBENZOICACID
  • m-Toluic acid, 2-nitro-
  • 3-Methyl-2-n
  • 2-Nitro-m-toluic acid, 3-Carboxy-2-nitrotoluene
  • Benzoic acid, 3-methyl-2-nitro-
  • 3-Methyl-2-nitrobenzoicAcid&gt
  • -2-nitrobenzoic acid
  • 3-Methyl-2-nitrobenzoic acid ISO 9001:2015 REACH
  • 3-Methyl-2-nitrobenzoic acid /Benzoic acid
  • Fluralaner-028
  • RSYY(Apremilast)-19
  • 3-Methy1-2-nitrobenzoic acid
  • Fluralaner Impurity 49
  • 5437-38-7
  • CH3NO2C6H3COOH
  • C8
  • Carbonyl Compounds
  • Carboxylic Acids
  • Organic Building Blocks
  • CARBOXYLIC ACID
  • Building Blocks
  • Building Blocks
  • C8
  • Carbonyl Compounds
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • Benzoic acid
  • Organic acids
  • FINE Chemical & INTERMEDIATES
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts