3-Methyl-2-nitrobenzoic acid

ChemicalBook > CAS DataBase List > 3-Methyl-2-nitrobenzoic acid

3-Methyl-2-nitrobenzoic acid

Product Name: 3-Methyl-2-nitrobenzoic acid
CAS No.: 5437-38-7
Chemical Name: 3-Methyl-2-nitrobenzoic acid
Synonyms: 2-NITRO-M-TOLUIC ACID;2-NITRO-3-METHYLBENZOIC ACID;BL-ME-0;3-Methyl-2-n;Fluralaner-028;RSYY(Apremilast)-19;3-Methyl-2-nitrobenz;-2-nitrobenzoic acid;Fluralaner Impurity 49;3-Methyl-2-nitrobenzoic
CBNumber: CB9223457
Molecular Formula: C8H7NO4
Formula Weight: 181.15
MOL File: 5437-38-7.mol

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3-Methyl-2-nitrobenzoic acid Property

Melting point:: 220-223 °C (lit.)
Boiling point:: 314.24°C (rough estimate)
Density: 1.4283 (rough estimate)
refractive index: 1.5468 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 2.26±0.10(Predicted)
color: White to Almost white
Water Solubility: <0.1 g/100 mL at 22 ºC
BRN: 1960698
InChI: InChI=1S/C8H7NO4/c1-5-3-2-4-6(8(10)11)7(5)9(12)13/h2-4H,1H3,(H,10,11)
InChIKey: DGDAVTPQCQXLGU-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference: 5437-38-7(CAS DataBase Reference)
EPA Substance Registry System: 3-Methyl-2-nitrobenzoic acid (5437-38-7)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22-37
WGK Germany: 3
TSCA: Yes
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M60406
Product name: 3-Methyl-2-nitrobenzoic acid
Purity: 98%
Packaging: 25g
Price: $30.5
Updated: 2023/06/20

Sigma-Aldrich

Product number: M60406
Product name: 3-Methyl-2-nitrobenzoic acid
Purity: 98%
Packaging: 100g
Price: $64
Updated: 2023/06/20

TCI Chemical

Product number: M1370
Product name: 3-Methyl-2-nitrobenzoic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $63
Updated: 2024/03/01

TCI Chemical

Product number: M1370
Product name: 3-Methyl-2-nitrobenzoic Acid
Purity: >98.0%(T)
Packaging: 250g
Price: $316
Updated: 2024/03/01

Alfa Aesar

Product number: B25682
Product name: 3-Methyl-2-nitrobenzoic acid, 98%
Packaging: 25g
Price: $52.65
Updated: 2024/03/01

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3-Methyl-2-nitrobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

2-Nitro-m-toluic Acid, is a building block used for the synthesis of various compounds. It can be used for the synthesis of novel Indolin-2-one derivatives as protein tyrosine phosphatase 1B inhibitors.

General Description

Prisms or white crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3-Methyl-2-nitrobenzoic acid is a nitrated carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry.

Fire Hazard

Information concerning the flash point of 3-Methyl-2-nitrobenzoic acid is not available. 3-Methyl-2-nitrobenzoic acid is probably combustible.

Purification Methods

Recrystallise it from EtOH. The methyl ester has m 74o (from MeOH), and the amide [60310-07-8] M 180.1, has m 192o (needles from H2O, prisms from EtOH). [Beilstein 9 H 480, 9 IV 1722.]

3-Methyl-2-nitrobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

3-METHYL-2-NITROBENZYL ALCOHOL 1H-Indole-7-carboxylic acid 3-methyl-2-nitrobenzoyl chloride Indole-7-carboxaldehyde

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View Lastest Price from 3-Methyl-2-nitrobenzoic acid manufacturers

Yancheng Green Chemicals Co.,Ltd

Product: 3-Methyl-2-nitrobenzoic acid 5437-38-7
Price: US $0.00/Kg/Bag
Min. Order: 25KG
Purity: 98%
Supply Ability: 200tons
Release date: 2020-07-20

Asia Chem I and E (Jiangsu) Co Ltd

Product: 3-Methyl-2-nitrobenzoic acid 5437-38-7
Price: US $20.93/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.50%HPLC
Supply Ability: 60tons/month
Release date: 2021-09-24

Henan Fengda Chemical Co., Ltd

Product: 3-Methyl-2-nitrobenzoic acid 5437-38-7
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

5437-38-7, 3-Methyl-2-nitrobenzoic acidRelated Search:

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3-Methyl-2-Nitrobenzoic Acid 98%

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3-Methyl-2-nitrobenzoic acid, 98% 25GR

3-METHY-2-NITROBENZOICACID

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3-Methyl-2-nitrobenzoic acid ISO 9001：2015 REACH

3-Methyl-2-nitrobenzoic acid /Benzoic acid

Fluralaner-028

RSYY(Apremilast)-19

Fluralaner Impurity 49

5437-38-7

CH3NO2C6H3COOH

Carbonyl Compounds

Carboxylic Acids

Organic Building Blocks

CARBOXYLIC ACID

Building Blocks

Carbonyl Compounds

Carboxylic Acids

Chemical Synthesis

Organic Building Blocks

Benzoic acid

Organic acids

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Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts