p-Toluic acid

ChemicalBook > CAS DataBase List > p-Toluic acid

Uses

Product Name: p-Toluic acid
CAS No.: 99-94-5
Chemical Name: p-Toluic acid
Synonyms: 4-METHYLBENZOIC ACID;PTLA;p-Tolylcarboxylic acid;4-TOLUIC ACID;para-Toluic acid;BENZOIC ACID, 4-METHYL-;p-toluic;P-TOLUYLIC ACID;p-carboxytoluene;P-METHYLBENZOIC ACID
CBNumber: CB7854776
Molecular Formula: C8H8O2
Formula Weight: 136.15
MOL File: 99-94-5.mol

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p-Toluic acid Property

Melting point:: 177-180 °C (lit.)
Boiling point:: 274-275 °C (lit.)
Density: 1,06 g/cm³
vapor pressure: 0.02 hPa (70 °C)
refractive index: 1.5120 (estimate)
Flash point:: 181°C
storage temp.: Store below +30°C.
solubility: 0.3g/l
form: Powder
pka: 4.36(at 25℃)
color: White to slightly yellow-cream
PH: 3.73(1 mM solution);3.2(10 mM solution);2.69(100 mM solution)
Water Solubility: <0.1 g/100 mL at 19 ºC
Merck: 14,9535
BRN: 507600
Stability:: Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey: LPNBBFKOUUSUDB-UHFFFAOYSA-N
LogP: 2.44
CAS DataBase Reference: 99-94-5(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 4-methyl-(99-94-5)
EPA Substance Registry System: Benzoic acid, 4-methyl- (99-94-5)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-24/25
WGK Germany: 1
RTECS: XU1575000
Autoignition Temperature: 570 °C
TSCA: Yes
HS Code: 29163900
Toxicity: LD50 orally in Rabbit: 400 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T36803
Product name: p-Toluic acid
Purity: 98%
Packaging: 5g
Price: $36.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 41768
Product name: p-Toluic acid
Purity: analytical standard
Packaging: 100mg
Price: $89.2
Updated: 2022/05/15

TCI Chemical

Product number: T0293
Product name: p-Toluic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $20
Updated: 2024/03/01

TCI Chemical

Product number: T0293
Product name: p-Toluic Acid
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $61
Updated: 2024/03/01

Alfa Aesar

Product number: A11506
Product name: p-Toluic acid, 98%
Packaging: 250g
Price: $49.4
Updated: 2024/03/01

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p-Toluic acid Chemical Properties,Usage,Production

Uses

p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.

Chemical Properties

colourless crystals or white crystalline powder. Slightly soluble in water; soluble in alcohol and ether. Combustible.

Uses

Intermediates of Liquid Crystals

Uses

Definition

ChEBI: A methylbenzoic acid in which the methyl substituent is located at position 4.

Synthesis Reference(s)

Journal of the American Chemical Society, 94, p. 4024, 1972 DOI: 10.1021/ja00766a069
The Journal of Organic Chemistry, 37, p. 2564, 1972 DOI: 10.1021/jo00981a010

Air & Water Reactions

Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. . Insoluble in water.

Reactivity Profile

p-Toluic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in p-Toluic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. p-Toluic acid is incompatible with strong oxidizers. p-Toluic acid is also incompatible with strong bases. .

Fire Hazard

Flash point data for p-Toluic acid are not available; however, p-Toluic acid is probably combustible.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the acid from water, water/EtOH (1:1), MeOH/water or *benzene. [Beilstein 9 IV 1724.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008]. The S-benzylisothiuronium salt has m 164o (from aqueous EtOH).

p-Toluic acid Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid P-XYLENE Oxygen Cobalt naphthenate Nitric acid p-Cymene

Preparation Products

4-HYDROXY-3-METHYLBENZOIC ACID METHYL 4-AMINO-6-INDOLECARBOXYLATE O,O-Bisisopropyl O-(4-(methylsulfinyl)phenyl) phosphorothioate 4-Bromomethylbenzamide 1-(3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)PHENYL)ETHANONE 4-(Chloromethyl)benzoic acid 4-(BROMOMETHYL)-N-(L-METHYLETHYL)BENZAMIDE 4-Bromomethylbenzoic acid 4-BROMOMETHYL BENZOYL BROMIDE 96 3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE p-Toluoyl chloride 2,3,5,6-Tetrafluoro-4-methylbenzyl alcohol

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View Lastest Price from p-Toluic acid manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: p-Toluic acid 99-94-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: p-Toluic acid 99-94-5
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

Hebei Mojin Biotechnology Co., Ltd

Product: p-Toluic acid 99-94-5
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000tons
Release date: 2020-06-23

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PTLA

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toluenecarboxylic acid

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Para-toluenic acid

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4-Methylbenzoic acid(Flakes or Chunks or Granular)

p-Toluic acid (8CI)

Para Toluic Acid,98%

Para Toluic Acid (4-Methyl Benzoic Acid)

Butafenacil Impurity 3

p-Toluic Acid, ≥ 98.0%

99-94-5

CH3C6H4CO2H

99945

ARYL ACID

Benzoic Acids (Building Blocks for Liquid Crystals)

Building Blocks for Liquid Crystals

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Carboxylic Acids