2-Fluoro-4-methoxyacetophenone
- Product Name
- 2-Fluoro-4-methoxyacetophenone
- CAS No.
- 74457-86-6
- Chemical Name
- 2-Fluoro-4-methoxyacetophenone
- Synonyms
- 1-(2-fluoro-4-Methoxyphenyl)ethan-1-one;4-ACETYL-3-FLUOROANISOLE;4-Methoxyphenacyl fluoride;2-fluor-4-methoxyacetophenone;2'-Fluoro-4'-Methoxyacetoph...;2-FLUORO-4-METHXOYACETOPHENONE;2-FLUORO-4-METHOXYACETOPHENONE;2'-Fluoro-4'-methoxyacetophenone;2'-Fluoro-4'-methoxylacetophenone;2'-Fluoro-4'-methoxyacetophenone99%
- CBNumber
- CB8711968
- Molecular Formula
- C9H9FO2
- Formula Weight
- 168.16
- MOL File
- 74457-86-6.mol
2-Fluoro-4-methoxyacetophenone Property
- Melting point:
- 52-54 °C(lit.)
- Boiling point:
- 80-85 °C (0.1 mmHg)
- Density
- 1.1410 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Viscous Solution
- color
- Clear colorless
- Water Solubility
- Insoluble
- BRN
- 3539992
- CAS DataBase Reference
- 74457-86-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 331686
- Product name
- 2′-Fluoro-4′-methoxyacetophenone
- Purity
- 99%
- Packaging
- 5g
- Price
- $56.1
- Updated
- 2023/06/20
- Product number
- F0662
- Product name
- 2'-Fluoro-4'-methoxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- F0662
- Product name
- 2'-Fluoro-4'-methoxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- F597445
- Product name
- 2''-Fluoro-4''-methoxyacetophenone
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F597445
- Product name
- 2''-Fluoro-4''-methoxyacetophenone
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
2-Fluoro-4-methoxyacetophenone Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2′-Fluoro-4′-methoxyacetophenone may be used in chemical synthesis.
Preparation
Obtained by reaction of acetic anhydride with 3-fluoroanisole in the presence of aluminium chloride in carbon disulfide at r.t., then at 30–35° until no more hydrochloric acid is evolved.
Synthesis
1313430-15-7
74457-86-6
3-Fluoro-4-methoxyacetophenone oxime ether (39.4 mg, 0.2 mmol) was dissolved in 2 mL of ether, 37% hydrochloric acid was added and the reaction was stirred for 30 h at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was neutralized with saturated sodium carbonate solution to pH 7, followed by extraction of the mixture with ether (10 mL × 3). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate = 20:1, v/v), and the eluent containing the target product was collected, and the solvent was removed by distillation under reduced pressure to afford 2-fluoro-4-methoxyacetophenone (26.5 mg, 79% yield).
References
[1] Patent: CN103922904, 2016, B. Location in patent: Paragraph 0058; 0059; 0062
2-Fluoro-4-methoxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-methoxyacetophenone manufacturers
- Product
- 2-Fluoro-4-methoxyacetophenone 74457-86-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- 2-Fluoro-4-methoxyacetophenone 74457-86-6
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%； 99%
- Supply Ability
- 1kg; 5kg; 10kg；25kg
- Release date
- 2020-01-07