4-FLUORO-2-METHOXYACETOPHENONE
- Product Name
- 4-FLUORO-2-METHOXYACETOPHENONE
- CAS No.
- 51788-80-8
- Chemical Name
- 4-FLUORO-2-METHOXYACETOPHENONE
- Synonyms
- 2-methoxy-4-fluoroacetophenone;4-FLUORO-2-METHOXYACETOPHENONE;4'-Fluoro-2'-methoxyacetophenone;4'-Fluoro-2'-methoxyacetophenone98%;4'-Fluoro-2'-methoxyacetophenone 98%;1-(4-fluoro-2-methoxyphenyl)ethanone;Ethanone, 1-(4-fluoro-2-methoxyphenyl)-;4′-Fluoro-2′-methoxyacetophenone, CAS 51788-80-8;4'-fluoro-2'-methoxyacetophenone,1-(4-fluoro-2-methoxyphenyl)ethanone
- CBNumber
- CB8382814
- Molecular Formula
- C9H9FO2
- Formula Weight
- 168.16
- MOL File
- 51788-80-8.mol
4-FLUORO-2-METHOXYACETOPHENONE Property
- Melting point:
- 51 °C
- Boiling point:
- 228.4±20.0 °C(Predicted)
- Density
- 1.127±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline powder
- color
- White
- BRN
- 2251986
- CAS DataBase Reference
- 51788-80-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2914500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F597448
- Product name
- 4''-Fluoro-2''-methoxyacetophenone
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 001409
- Product name
- 4'-Fluoro-2'-methoxyacetophenone
- Purity
- 98%
- Packaging
- 25g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- J56857
- Product name
- 4-Fluoro-2-methoxyacetophenone
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 2617-3-14
- Product name
- 4'-Fluoro-2'-methoxyacetophenone
- Purity
- 98%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 001409
- Product name
- 4'-Fluoro-2'-methoxyacetophenone
- Purity
- 98%
- Packaging
- 5g
- Price
- $33
- Updated
- 2021/12/16
4-FLUORO-2-METHOXYACETOPHENONE Chemical Properties,Usage,Production
Uses
4''-Fluoro-2''-methoxyacetophenone
Preparation
Preparation by reaction of methyl iodide with 4-fluoro-2-hydroxyacetophenone in the presence of potassium carbonate,
? in DMSO at r.t. for 1 h (100%);
? in acetone (97%).
Synthesis
1481-27-2
74-88-4
51788-80-8
4-Fluoro-2-hydroxyacetophenone (12.0 g, 77.9 mmol) was reacted with iodomethane (6.38 ml, 101 mmol) and potassium carbonate (14.0 g, 101 mmol) in acetonitrile (200 ml) at 75 °C for 8 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered and concentrated under reduced pressure to remove the solvent. To the residue was added fresh acetonitrile (150 ml), iodomethane (2 ml, 32 mmol) and potassium carbonate (4 g, 29 mmol) and the reaction was continued at 75°C for 3 hours. The reaction mixture was concentrated, diluted by adding ethyl acetate (100 ml), filtered and the solvent was evaporated under reduced pressure to give 4-fluoro-2-methoxyacetophenone (13.5 g, 100% yield). Mass spectral data: m/z 168 (M+, 11), 153 (base peak), 110 (23), 95 (21), 82 (12).
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 15, p. 3823 - 3842
[2] Patent: WO2009/133110, 2009, A1. Location in patent: Page/Page column 38
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1590 - 1595
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1583 - 1598
[5] Journal of Medicinal Chemistry, 1999, vol. 42, # 20, p. 4150 - 4160
4-FLUORO-2-METHOXYACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUORO-2-METHOXYACETOPHENONE manufacturers
- Product
- 4'-Fluoro-2'-methoxyacetophenone 51788-80-8
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 4-FLUORO-2-METHOXYACETOPHENONE 51788-80-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-08