ChemicalBook > CAS DataBase List > 2-Fluoro-4-methoxyacetophenone

2-Fluoro-4-methoxyacetophenone

Product Name: 2-Fluoro-4-methoxyacetophenone
CAS No.: 74457-86-6
Chemical Name: 2-Fluoro-4-methoxyacetophenone
Synonyms: 1-(2-fluoro-4-Methoxyphenyl)ethan-1-one;4-ACETYL-3-FLUOROANISOLE;4-Methoxyphenacyl fluoride;2-fluor-4-methoxyacetophenone;2'-Fluoro-4'-Methoxyacetoph...;2-FLUORO-4-METHXOYACETOPHENONE;2-FLUORO-4-METHOXYACETOPHENONE;2'-Fluoro-4'-methoxyacetophenone;2'-Fluoro-4'-methoxylacetophenone;2'-Fluoro-4'-methoxyacetophenone99%
CBNumber: CB8711968
Molecular Formula: C9H9FO2
Formula Weight: 168.16
MOL File: 74457-86-6.mol

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2-Fluoro-4-methoxyacetophenone Property

Melting point:: 52-54 °C(lit.)
Boiling point:: 80-85 °C (0.1 mmHg)
Density: 1.1410 (estimate)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
form: Viscous Solution
color: Clear colorless
Water Solubility: Insoluble
BRN: 3539992
CAS DataBase Reference: 74457-86-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 331686
Product name: 2′-Fluoro-4′-methoxyacetophenone
Purity: 99%
Packaging: 5g
Price: $56.1
Updated: 2023/06/20

TCI Chemical

Product number: F0662
Product name: 2'-Fluoro-4'-methoxyacetophenone
Purity: >98.0%(GC)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: F0662
Product name: 2'-Fluoro-4'-methoxyacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TRC

Product number: F597445
Product name: 2''-Fluoro-4''-methoxyacetophenone
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

TRC

Product number: F597445
Product name: 2''-Fluoro-4''-methoxyacetophenone
Packaging: 500mg
Price: $45
Updated: 2021/12/16

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2-Fluoro-4-methoxyacetophenone Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2′-Fluoro-4′-methoxyacetophenone may be used in chemical synthesis.

Preparation

Obtained by reaction of acetic anhydride with 3-fluoroanisole in the presence of aluminium chloride in carbon disulfide at r.t., then at 30–35° until no more hydrochloric acid is evolved.

Synthesis

1313430-15-7

74457-86-6

3-Fluoro-4-methoxyacetophenone oxime ether (39.4 mg, 0.2 mmol) was dissolved in 2 mL of ether, 37% hydrochloric acid was added and the reaction was stirred for 30 h at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was neutralized with saturated sodium carbonate solution to pH 7, followed by extraction of the mixture with ether (10 mL × 3). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate = 20:1, v/v), and the eluent containing the target product was collected, and the solvent was removed by distillation under reduced pressure to afford 2-fluoro-4-methoxyacetophenone (26.5 mg, 79% yield).

References

[1] Patent: CN103922904, 2016, B. Location in patent: Paragraph 0058; 0059; 0062

2-Fluoro-4-methoxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-methoxyacetophenone Suppliers

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View Lastest Price from 2-Fluoro-4-methoxyacetophenone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Fluoro-4-methoxyacetophenone 74457-86-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

Career Henan Chemical Co

Product: 2-Fluoro-4-methoxyacetophenone 74457-86-6
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%； 99%
Supply Ability: 1kg; 5kg; 10kg；25kg
Release date: 2020-01-07

74457-86-6, 2-Fluoro-4-methoxyacetophenoneRelated Search:

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2'-Fluoro-4'-methoxyacetophenone&gt

2'-Fluoro-4'-methoxyacetophenone

2′-Fluoro-4′-methoxyacetophenone, CAS 74457-86-6

74457-86-6

Ketones

Organic Building Blocks

Carbonyl Compounds

Building Blocks

Aromatic Acetophenones & Derivatives (substituted)

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds

Carbonyl Compounds

Ketones

Fluorine series