2-Bromo-4'-methoxyacetophenone

Product Name: 2-Bromo-4'-methoxyacetophenone
CAS No.: 2632-13-5
Chemical Name: 2-Bromo-4'-methoxyacetophenone
Synonyms: 2-BROMO-1-(4-METHOXYPHENYL)ETHAN-1-ONE;2-BROMO-1-(4-METHOXYPHENYL)ETHANONE;PTP Inhibitor II;4-methoxy phenecyl bromide;PTP inhibitor 1;AKOS BBS-00000817;2-Bromo-4-methoxy;TIMTEC-BB SBB007777;4-METHOXYPHENACYL BR;2-Bromo-4'-methoxyac
CBNumber: CB2715762
Molecular Formula: C9H9BrO2
Formula Weight: 229.07
MOL File: 2632-13-5.mol

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2-Bromo-4'-methoxyacetophenone Property

Melting point:: 69-71 °C(lit.)
Boiling point:: 215.8°C (rough estimate)
Density: 1.4921 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Crystals or Crystalline Powder
color: Off-white to light brown
Water Solubility: It is soluble in DMSO, water (partly miscible), most organic solvents, and methanol.
BRN: 743112
InChI: InChI=1S/C9H9BrO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
InChIKey: XQJAHBHCLXUGEP-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(OC)C=C1)CBr
CAS DataBase Reference: 2632-13-5(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 2-bromo-1-(4-methoxyphenyl)-(2632-13-5)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37-36/37/38
Safety Statements: 26-27-28-36/37/39-45-37/39
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 8-9-19-21
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29147090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 115665
Product name: 2-Bromo-4′-methoxyacetophenone
Purity: 97%
Packaging: 5g
Price: $83.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 115665
Product name: 2-Bromo-4′-methoxyacetophenone
Purity: 97%
Packaging: 25g
Price: $399
Updated: 2024/03/01

TCI Chemical

Product number: M1004
Product name: 4'-Methoxyphenacyl Bromide
Purity: >98.0%(GC)
Packaging: 5g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: M1004
Product name: 4'-Methoxyphenacyl Bromide
Purity: >98.0%(GC)
Packaging: 25g
Price: $85
Updated: 2024/03/01

Alfa Aesar

Product number: A13415
Product name: 2-Bromo-4'-methoxyacetophenone, 98%
Packaging: 5g
Price: $33.65
Updated: 2024/03/01

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2-Bromo-4'-methoxyacetophenone Chemical Properties,Usage,Production

Chemical Properties

off-white to light brown crystals or

Uses

2-Bromo-4'-methoxyacetophenone, is used as a cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor.

Uses

2-Bromo-4'-methoxyacetophenone is a α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.

Preparation

Obtained by reaction of N-bromosuccinimide (NBS) with 4-methoxyacetophenone in the presence of trimethylsilyl trifluoromethanesulfonate (TMS-OTf) in acetonitrile at r.t. for 24 h (87%).

Biological Activity

ki: 128 μmptp inhibitor ii is a protein tyrosine phosphatase (ptp) inhibitor.protein tyrosine phosphatases (ptps) are reported to be involved in the etiology of diabetes mellitus, neural diseases such as alzheimer and parkinson diseases, regulation of allergy and inflammation, or ptps are even regarded to be responsible for the pathogens.

in vitro

in a previous study, it was found that all of the previously reported ptp inhibitors contained a negatively charged, nonhydrolyzable py mimetic as the core structure, such as malonates, aryl carboxylates, phosphonates, or cinnamates. the poor membrane permeability of these inhibitors might compromise their potential development. it was reported that several α-bromoacetophenone derivatives, such as ptp inhibitor ii, could act as fairly potent ptp inhibitors, by covalently alkylating the conserved catalytic cysteine in the ptp active site. since ptp inhibitor ii is neutral, it could readily diffuse into human b cells and inhibit the intracellular ptps. the sar study was performed with the catalytic domain of phosphatase shp-1, and ti was found that ptp inhibitor ii showed time-dependent inactivation of shp-1, consistent with the mechanism. furthermore, the potency of ptp inhibitor ii was described by an equilibrium constant ki, representing the dissociation constant of the noncovalent enzyme–inhibitor complex. ptp inhibitor ii bound with lower affinity than ptp inhibitor i with ki values of 128 μm [1].

References

[1] p. heneberg. use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. current medicinal chemistry 16(6), 706-733 (2009).

2-Bromo-4'-methoxyacetophenone Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone Hexane Sodium chloride SILICA Ethyl acetate Sodium bicarbonate Government regulation Acetic acid Magnesium sulfate

Preparation Products

Raloxifene 4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE 2-(4-METHOXYBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE

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2-Bromo-4'-methoxyacetophenone Suppliers

Americas 1 Austria 1 Belgium 4 Canada 3 China 240 Europe 3 France 1 Germany 7 India 67 Israel 2 Japan 6 Slovakia 1 South Korea 2 Switzerland 3 Ukraine 2 United Kingdom 17 United States 61 Global 421

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View Lastest Price from 2-Bromo-4'-methoxyacetophenone manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 2-Bromopropionyl bromide 2632-13-5
Price: US $40.00-10.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 15 tons
Release date: 2023-10-10

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Bromo-4'-methoxyacetophenone 2632-13-5
Price: US $30.00-10.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-23

Hebei Mojin Biotechnology Co., Ltd

Product: 2-Bromo-4'-methoxyacetophenone 2632-13-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-26

2632-13-5, 2-Bromo-4'-methoxyacetophenoneRelated Search:

3,4-Dimethoxyacetophenone Acetophenone Ethidium bromide 4'-Bromoacetophenone 3-Nitroacetophenone Chalcone Sodium bromate 3'-Bromoacetophenone Clidinium bromide L-PICEIN 4'-Methylacetophenone 3',5'-Dimethoxyacetophenone 2-Methoxyethanol 3-Bromoanisole 4'-Methoxyacetophenone 2'-Methoxyacetophenone 4-Nitroacetophenone 4'-Hydroxyacetophenone

ALPHA-BROMO-4'-METHOXYACETOPHENONE

ALPHA-BROMO-4-METHOXYACETOPHENONE

AKOS BBS-00000817

Bromomethyl 4-methoxyphenyl ketone

4-(BROMOACETYL)ANISOLE

4-methoxy phenecyl bromide

4-METHOXYPHENACYL BR

4'-METHOXYPHENACYL BROMIDE

4-METHOXYPHENACYL BROMIDE

A-BROMO-P-METHOXYACETOPHENONE

2-BROMO-1-(4-METHOXYPHENYL)ETHAN-1-ONE

2-BROMO-1-(4-METHOXYPHENYL)ETHANONE

2-BROMO-4-METHOXY ACETOPHENONE

TIMTEC-BB SBB007777

OMEGA-BROMO-P-METHOXY ACETOPHENONE

OMEGA-BROMO-4-METHOXYACETOPHENONE

P-METHOXYPHENACYL BROMIDE

PROTEIN TYROSINE PHOSPHATASE INHIBITOR II

W-BROMO-4-METHOXY-ACETOPHENONE

2-(4-Methoxyphenyl)-2-oxoethyl bromide

2-Bromo-1-(4-methoxyphenyl)-1-ethanone

Ethanone, 2-bromo-1-(4-methoxyphenyl)-

2-Bromo-4-methoxy

ω-bromo-4-methoxyacetophenone

2-Bromo-4'-methoxyacetophenone, Pract.

2-Bromo-4'-methoxyacetophenone, 2-Bromo-1-(4-methoxyphenyl)ethan-1-one

P-Methoxy-A-Bromoacetophenone

2-BROMO-4''-METHOXYACETOPHENONE (4-METHOXYPHENACYL BROMIDE)

2-bromo-1-(4-methoxyphenyl)-ethanon

2-Bromo-p-methoxyacetophenone

4'-Methoxy-2-bromoacetophenone

a-Bromo-4'-methoxyacetophenone

Acetophenone, 2-bromo-4'-methoxy-

alpha-Bromo-p-methoxyacetophenone

Bromomethyl p-anisyl ketone

w-Bromo-p-methoxyacetophenone

PTP Inhibitor II

2-Bromo-4'-Methoxyacetophenone 4'-Methoxyphenacyl Bromide 2-Bromo-1-(4-Methoxyphenyl)ethan-1-one

p-Methoxy-alpha-Chloroacetophenone

Bromo Methoxy Acetophenone

1-(2-bromo-4-methoxyphenyl)ethanone

P-Methoxy-α-bromoacetophenone

ω-Bromo-4-methoxyacetophenone, 4-Methoxyphenacyl bromide

2-(4-Methoxyphenyl)-2-oxoethyl bromid

1-(4-Mehtoxyphenyl)-2-bromoethanone

1-(Bromoacetyl)-4-methoxybenzene

4'-Methoxy-α-bromoacetophenone

2-Bromo-4'-methoxyacetophenone,98%

2-Bromo-4′-methoxyacetophenone,ω-Bromo-4-methoxyacetophenone, 4-Methoxyphenacyl bromide

2-Bromo-4'-methoxyac

2-Bromo-4'-methoxyacetophenone, 2-Bromo-1-(4-methoxyphenyl)ethan-1-one, 4-(Bromoacetyl)anisole

4-Methoxyphenacyl Bromide 98%

2-BroMo-1-[4-(Methyloxy)phenyl] ethanone

alpha-Bromo-4'-methoxyacetophenone 4-(Bromoacetyl)anisole

2-BroMo-4'-Methoxyacetophenone 97%

4-Methoxyphenacylbromide,98%

Para Methoxy Phenacyl Bromide

2-Bromo-4'-methoxyacetophenone, 98%, reagent grade