2-Bromo-4'-methoxyacetophenone
- Product Name
- 2-Bromo-4'-methoxyacetophenone
- CAS No.
- 2632-13-5
- Chemical Name
- 2-Bromo-4'-methoxyacetophenone
- Synonyms
- 2-BROMO-1-(4-METHOXYPHENYL)ETHAN-1-ONE;2-BROMO-1-(4-METHOXYPHENYL)ETHANONE;PTP Inhibitor II;4-methoxy phenecyl bromide;PTP inhibitor 1;AKOS BBS-00000817;2-Bromo-4-methoxy;TIMTEC-BB SBB007777;4-METHOXYPHENACYL BR;2-Bromo-4'-methoxyac
- CBNumber
- CB2715762
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 2632-13-5.mol
2-Bromo-4'-methoxyacetophenone Property
- Melting point:
- 69-71 °C(lit.)
- Boiling point:
- 215.8°C (rough estimate)
- Density
- 1.4921 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Crystals or Crystalline Powder
- color
- Off-white to light brown
- Water Solubility
- It is soluble in DMSO, water (partly miscible), most organic solvents, and methanol.
- BRN
- 743112
- InChI
- InChI=1S/C9H9BrO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
- InChIKey
- XQJAHBHCLXUGEP-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=C(OC)C=C1)CBr
- CAS DataBase Reference
- 2632-13-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 2-bromo-1-(4-methoxyphenyl)-(2632-13-5)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37-36/37/38
- Safety Statements
- 26-27-28-36/37/39-45-37/39
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 8-9-19-21
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29147090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 115665
- Product name
- 2-Bromo-4′-methoxyacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $83.8
- Updated
- 2024/03/01
- Product number
- 115665
- Product name
- 2-Bromo-4′-methoxyacetophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $399
- Updated
- 2024/03/01
- Product number
- M1004
- Product name
- 4'-Methoxyphenacyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $30
- Updated
- 2024/03/01
- Product number
- M1004
- Product name
- 4'-Methoxyphenacyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $85
- Updated
- 2024/03/01
- Product number
- A13415
- Product name
- 2-Bromo-4'-methoxyacetophenone, 98%
- Packaging
- 5g
- Price
- $33.65
- Updated
- 2024/03/01
2-Bromo-4'-methoxyacetophenone Chemical Properties,Usage,Production
Chemical Properties
off-white to light brown crystals or
Uses
2-Bromo-4'-methoxyacetophenone, is used as a cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor.
Uses
2-Bromo-4'-methoxyacetophenone is a α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.
Preparation
Obtained by reaction of N-bromosuccinimide (NBS) with 4-methoxyacetophenone in the presence of trimethylsilyl trifluoromethanesulfonate (TMS-OTf) in acetonitrile at r.t. for 24 h (87%).
Biological Activity
ki: 128 μmptp inhibitor ii is a protein tyrosine phosphatase (ptp) inhibitor.protein tyrosine phosphatases (ptps) are reported to be involved in the etiology of diabetes mellitus, neural diseases such as alzheimer and parkinson diseases, regulation of allergy and inflammation, or ptps are even regarded to be responsible for the pathogens.
in vitro
in a previous study, it was found that all of the previously reported ptp inhibitors contained a negatively charged, nonhydrolyzable py mimetic as the core structure, such as malonates, aryl carboxylates, phosphonates, or cinnamates. the poor membrane permeability of these inhibitors might compromise their potential development. it was reported that several α-bromoacetophenone derivatives, such as ptp inhibitor ii, could act as fairly potent ptp inhibitors, by covalently alkylating the conserved catalytic cysteine in the ptp active site. since ptp inhibitor ii is neutral, it could readily diffuse into human b cells and inhibit the intracellular ptps. the sar study was performed with the catalytic domain of phosphatase shp-1, and ti was found that ptp inhibitor ii showed time-dependent inactivation of shp-1, consistent with the mechanism. furthermore, the potency of ptp inhibitor ii was described by an equilibrium constant ki, representing the dissociation constant of the noncovalent enzyme–inhibitor complex. ptp inhibitor ii bound with lower affinity than ptp inhibitor i with ki values of 128 μm [1].
References
[1] p. heneberg. use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. current medicinal chemistry 16(6), 706-733 (2009).
2-Bromo-4'-methoxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-4'-methoxyacetophenone Suppliers
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View Lastest Price from 2-Bromo-4'-methoxyacetophenone manufacturers
- Product
- 2-Bromopropionyl bromide 2632-13-5
- Price
- US $40.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 15 tons
- Release date
- 2023-10-10
- Product
- 2-Bromo-4'-methoxyacetophenone 2632-13-5
- Price
- US $30.00-10.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 100000kg
- Release date
- 2024-08-23
- Product
- 2-Bromo-4'-methoxyacetophenone 2632-13-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-26