2-Bromoacetophenone

Product Name: 2-Bromoacetophenone
CAS No.: 70-11-1
Chemical Name: 2-Bromoacetophenone
Synonyms: 2-BROMO-1-PHENYLETHANONE;A-BROMOACETOPHENONE;1-Phenyl-2-broMoethanone;NSC 9807;Stauffer 4644;AKOS BBS-00004003;Bromoacetylbenzene;-Bromoacetophenone;PhenacylBromide>w-Bromoacetophenone
CBNumber: CB6305185
Molecular Formula: C8H7BrO
Formula Weight: 199.04
MOL File: 70-11-1.mol

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2-Bromoacetophenone Property

Melting point:: 48-51 °C (lit.)
Boiling point:: 135 °C/18 mmHg (lit.)
Density: 1.476
refractive index: 1.5700 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Crystals or Powder
color: White to dark green-brown
Water Solubility: PRACTICALLY INSOLUBLE
Merck: 14,1402
BRN: 606474
Stability:: Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChIKey: LIGACIXOYTUXAW-UHFFFAOYSA-N
CAS DataBase Reference: 70-11-1(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 2-bromo-1-phenyl-(70-11-1)
EPA Substance Registry System: Ethanone, 2-bromo-1-phenyl- (70-11-1)

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Safety

Hazard Codes: C
Risk Statements: 34-20/21/22
Safety Statements: 26-36/37/39-45
RIDADR: UN 2645 6.1/PG 2
WGK Germany: 3
F: 8-19
Hazard Note: Corrosive
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29143990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 115835
Product name: 2-Bromoacetophenone
Purity: 98%
Packaging: 5g
Price: $39.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 115835
Product name: 2-Bromoacetophenone
Purity: 98%
Packaging: 100g
Price: $92.5
Updated: 2024/03/01

TCI Chemical

Product number: A5508
Product name: Phenacyl Bromide [for HPLC Labeling]
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $31
Updated: 2024/03/01

TCI Chemical

Product number: B0535
Product name: Phenacyl Bromide
Purity: >98.0%(GC)
Packaging: 25g
Price: $56
Updated: 2024/03/01

Alfa Aesar

Product number: A15576
Product name: 2-Bromoacetophenone, 98%
Packaging: 25g
Price: $37.6
Updated: 2023/06/20

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2-Bromoacetophenone Chemical Properties,Usage,Production

Chemical Properties

Off white-grey green crystaline powder

Uses

2-Bromoacetophenone is a brominated acteophenone derivative. 2-Bromoacetophenone has been shown to completely and irreversibly inactivate human liver aldehyde dehydrogenase (EC 1.2.1.3) isoenzymes E1 and E2. 2-Bromoacetophenone and its derivatives display some inhibitory activity on neutral protein tyrosine.inhibitors

Uses

It is used in preparation of crystalline esters from acids. 2-Bromoacetophenone is a complete and irreversible inactivator of human liver aldehyde dehydrogenase isoenzymes E1 and E2.

Definition

ChEBI: An alpha-bromoketone that is acetophenone substituted by a bromo group at position 2.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 5796, 1954 DOI: 10.1021/ja01651a061
Organic Syntheses, Coll. Vol. 2, p. 480, 1943
Synthetic Communications, 22, p. 1923, 1992 DOI: 10.1080/00397919208021322

General Description

A crystalline solid or a liquid with a sharp odor. Toxic by inhalation, ingestion and skin absorption. A severe eye irritant (a lachrymator). Used to make other chemicals.

Air & Water Reactions

Reacts slowly with moisture in air to form hydrogen bromide.

Reactivity Profile

2-Bromoacetophenone reacts slowly with metals causing mild corrosion.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Purification Methods

Crystallise the bromide from EtOH, MeOH or pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 649.]

2-Bromoacetophenone Preparation Products And Raw materials

Raw materials

Acetone Bromobenzene Government regulation

Preparation Products

A-BROMO-4-NITROACETOPHENONE HEXAMINE 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE 3-(-Hydroxyphenethyl)-2-imino thiazolidine 4-PHENYL-1,2,3-THIADIAZOL-5-AMINE DIETHOXYMETHANE 1-Phenacylpyridinium bromide 5-AMINO-3-PHENYLISOXAZOLE 4-AMINO-ALPHA-TERT-BUTYLAMINE-3,5-DICHLOROACETOPHENONE 2-(2-iminothiazolidin-3-yl)-1-phenylethan-1-one monohydrobromide 4-Acetyloxy-3-acetyloxymethyl-(N-benzyl-N-tertbutylamino)acetophenone hydrochloride 2-Phenylindole N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxoethyl]acetamide

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2-Bromoacetophenone Suppliers

Americas 1 Belgium 1 Canada 3 China 228 Europe 4 France 1 Germany 6 India 29 Israel 1 Japan 9 Poland 1 Russia 1 Slovakia 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 12 United States 45 Global 348

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Shandong Qianyuan Polymer Material Co. , Ltd.

Tel: 18678041314 18765609661
Email: 2547772582@qq.com
Country: China
ProdList: 877
Advantage: 58

Sichuan Ruibo Technology Co., Ltd

Tel: +86-817-5586080
Fax: +86-817-5527378
Country: China
ProdList: 42
Advantage: 69

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Liaoning Tianhua Chemical Co., Ltd.

Tel: 0418-6530555 2855550
Fax: +86-418-6502885
Country: China
ProdList: 338
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

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View Lastest Price from 2-Bromoacetophenone manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 2-Bromoacetophenone 70-11-1
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-13

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Bromoacetophenone 70-11-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-11-15

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Bromoacetophenone 70-11-1
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-21

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Building Blocks

Acylation