Identification Description Regulatory Status Usage Natural occurrence
ChemicalBook > CAS DataBase List > 4'-Methoxyacetophenone

4'-Methoxyacetophenone

Identification Description Regulatory Status Usage Natural occurrence
Product Name
4'-Methoxyacetophenone
CAS No.
100-06-1
Chemical Name
4'-Methoxyacetophenone
Synonyms
4-METHOXYACETOPHENONE;ACETANISOLE;1-(4-METHOXYPHENYL)ETHANONE;4-ACETYLANISOLE;P-ACETYLANISOLE;Acetanisol;P-METHOXYACETOPHENONE;Ethanone, 1-(4-methoxyphenyl)-;Vananote;p-Acetoanisole
CBNumber
CB1132155
Molecular Formula
C9H10O2
Formula Weight
150.17
MOL File
100-06-1.mol
More
Less

4'-Methoxyacetophenone Property

Melting point:
36-38 °C (lit.)
Boiling point:
152-154 °C/26 mmHg (lit.)
Density 
1.08
vapor pressure 
0.42Pa at 20℃
refractive index 
1.5470 (estimate)
FEMA 
2005 | ACETANISOLE
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: soluble2.474g/L at 20°C
form 
Crystals or Crystalline Powder
color 
White
Odor
at 100.00 %. sweet hawthorn anisic powdery balsamic acacia
Odor Type
anisic
biological source
synthetic
Water Solubility 
insoluble
Sensitive 
Light Sensitive
JECFA Number
810
BRN 
742313
InChIKey
NTPLXRHDUXRPNE-UHFFFAOYSA-N
LogP
1.79 at 20℃
CAS DataBase Reference
100-06-1(CAS DataBase Reference)
NIST Chemistry Reference
Acetophenone, 4'-methoxy-(100-06-1)
EPA Substance Registry System
4'-Methoxyacetophenone (100-06-1)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-38-36/38-20/21/22
Safety Statements 
37-37/39-26-36
WGK Germany 
2
RTECS 
AM9240000
TSCA 
Yes
HS Code 
29145000
Hazardous Substances Data
100-06-1(Hazardous Substances Data)
Toxicity
The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973).
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
1kg
Price
$141
Updated
2024/03/01
Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
5kg
Price
$461
Updated
2024/03/01
Sigma-Aldrich
Product number
117374
Product name
4′-Methoxyacetophenone
Purity
99%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
117374
Product name
4′-Methoxyacetophenone
Purity
99%
Packaging
1kg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
W200506
Product name
Acetanisole
Purity
≥98%, FCC, FG
Packaging
25kg
Price
$1650
Updated
2023/06/20
More
Less

4'-Methoxyacetophenone Chemical Properties,Usage,Production

Identification

CAS.No.: 
100-06-1 
FL.No.: 
7.038
FEMA.No.: 
2005
NAS.No.: 
2005
CoE.No.: 
570
EINECS.No.: 
202-815-9 
JECFA.No.: 
810
　
　

Description

Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors.

Regulatory Status

CoE: Approved. Bev.: 10 ppm; Food: 20 ppm
FDA: 21 CFR 172.515
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001).

Usage

Reported uses (ppm): (FEMA, 1994)

Food Category 
Usual 
Max. 
Alcoholic.beverages 
0.0001
0.0001
Baked.goods 
1.5
2
Chewing.gum 
110
110
Frozen.dairy 
1
2
Gelatins,.puddings 
0.2
0.2
Hard.candy 
278.3
335
Meat.products 
100
100
Nonalcoholic.beverages 
7.8
150
Soft.candy 
2.1
31

Natural occurrence

Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).

Chemical Properties

Colorless crystals or fused crystalline/Yellowish-white crystals mass. with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors. Heavier than water, practically insoluble in water. Miscible with oils, soluble in alcohol, Relatively stable in soap and under similar, mild-alkaline conditions.

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

Chemical Properties

4-Methoxyacetophenone occurs in anise oil. It forms white crystals (mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone is prepared by Friedel–Crafts acetylation of anisole. A modern process uses ??-zeolites as Friedel–Crafts catalysts in combination with a continuous flow technology. 4-Methoxyacetophenone is used in soap perfumes

Occurrence

Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).

Uses

4'-Methoxyacetophenone is used as a component of perfumes and as chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents. And also used to study ruthenium catalyzed step growth copolymerization of 4?-methoxyacetophenone with α,ω-dienes to yield copolymers.

Uses

4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone.

Uses

Perfumery (for floral odors), flavoring.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4.

Preparation

From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid in the presence of boron trifluoride.

Taste threshold values

Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances.

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI: 10.1021/jo00339a036
Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617
Tetrahedron Letters, 35, p. 9471, 1994 DOI: 10.1016/S0040-4039(00)78574-1

General Description

4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system.

Flammability and Explosibility

Not classified

Safety Profile

Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]

Toxics Screening Level

The ITSL for 4-methoxyacetophenone has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.

4'-Methoxyacetophenone Preparation Products And Raw materials

Raw materials

Bentonite,calcium base Acetyl chloride Anisole Ferric chloride Aluminum chloride Aluminium chloride hexahydrate

Preparation Products

4-(1,2,3-THIADIAZOL-4-YL)PHENOL 3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxamide ,97% 5-AMINO-3-(4-METHOXYPHENYL)ISOXAZOLE 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOHYDRAZIDE 4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOLE 2-Bromo-4'-methoxyacetophenone 5-(4-METHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 5-(4-METHOXY-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE 4-Methoxyphenylacetic acid ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID CHLOROTRIANISENE
More
Less

4'-Methoxyacetophenone Suppliers

Americas 1 Australia 1 Belgium 4 Canada 3 China 499 Europe 4 France 2 Germany 10 India 77 Italy 1 Japan 8 Poland 1 Singapore 1 Slovakia 1 South Korea 2 Spain 2 Switzerland 4 Ukraine 1 United Kingdom 14 United States 66 USA 1 Global 703
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
867
Advantage
58
Chengtian Fine Chemical Co., Ltd
Tel
18164098996
Fax
027-87680390
Email
3554657675@qq.com
Country
China
ProdList
6670
Advantage
58
Weifang Weimeng Chemical Co., Ltd.
Tel
0536-8790166 15105445095
Email
weimengchem@163.com
Country
China
ProdList
473
Advantage
58
Shandong Chenyi Environmental Protection Technology Co., Ltd
Tel
0531-83179999 13395316108
Email
cyhbkjyxgs@163.com
Country
China
ProdList
126
Advantage
58
Shanghai Taijilin Industrial Co., Ltd.
Tel
021-021-50630626 18964684208
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1243
Advantage
58
SINO HIGH(CHINA)CO.,LTD.
Tel
13914336446 15151073745
Email
chang@sinohighchem.com
Country
China
ProdList
39
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9371
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12386
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
jiliang chemicals
Tel
21-62165282 15801962796;
Fax
021 61153784
Email
bidingchem@163.com
Country
China
ProdList
1201
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8835
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9478
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Ascepion Pharmaceuticals, Inc.
Tel
+86-512-86881668
Fax
+86-512-62956001
Country
China
ProdList
100
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18021050169
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Zouping Mingxing Chemical Co.,Ltd.
Tel
86-13605431940 13605431940
Fax
0086-0543-2240079
Email
zpmxchemical@126.com
Country
China
ProdList
1482
Advantage
62
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Sinfachem Limited
Tel
025-84683399 13952017251
Fax
025-84683112
Email
sales@sinfachem.com
Country
China
ProdList
217
Advantage
56
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
More
Less

View Lastest Price from 4'-Methoxyacetophenone manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
4'-Methoxyacetophenone 100-06-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-06
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4'-Methoxyacetophenone 100-06-1
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-14
Shandong Deshang Chemical Co., Ltd.
Product
4'-Methoxyacetophenone 100-06-1
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
10 tons
Release date
2024-06-13

100-06-1, 4'-MethoxyacetophenoneRelated Search:

3,4-Dimethoxyacetophenone Chalcone Acetophenone 4'-Hydroxyacetophenone 4'-Bromoacetophenone 2-Bromoacetophenone 2-Fluoro-4-methoxyacetophenone 4-Methoxyphenethylamine 3-Nitroacetophenone 4-Methoxyphenylacetic acid 4'-Methylacetophenone 4-Nitroacetophenone 4-Methoxybenzyl cyanide 4-Methoxystyrene 4-Methylbenzyl cyanide 4'-Methylpropiophenone Methoxypropiophenone p-Anisaldehyde Para Methoxy Acetophenone

  • 4'-Methoxyacetophenone≥ 99% (GC)
  • 4'-Methoxyacetophenone p-Acetanisole 4-Methoxyacetophenone
  • Para Methoxyl Acetophenone
  • ACETANISOLE 98+% FCC
  • 4-Methoxyacetophenone,>99%
  • Epenone
  • P-METHOXY ACETOPLENONE
  • PARA-METHOXYACETONPHENONE
  • ACETYLANISOLE
  • LABOTEST-BB LT01595901
  • FEMA 2005
  • Ethanone,1-(4-methoxyphenyl)-
  • Linarodin
  • Methyl p-methoxyphenyl ketone
  • Novatone
  • p-Acetoanisole
  • p-Methoxyphenyl methyl ketone
  • p-methoxyphenylmethylketone
  • Vananote
  • PARA METHOXY ACETOPHENONE
  • P-ACETYLANISOLE
  • P-ACETANISOLE
  • VANATONE
  • 4-ACETOANISOLE
  • 4-METHOXYPHENYLETHANONE
  • 4-METHOXYACETOPHENONE
  • 4-ACETYLANISOLE
  • AKOS 90580
  • AKOS BBS-00003216
  • ACETANISOLE
  • 1-(4-METHOXYPHENYL)ETHANONE
  • 4'-Methoxyacetophenone 100-06-1 kf-wang(at)kf-chem.com
  • 4'-Methoxyacetophenone p-Acetanisole p-Acetylanisole
  • 1-(4-methoxyphenyl)-ethanon
  • 4’-methoxy-acetophenon
  • 4-Methoxyacetofenon
  • 4-Methoxyphenyl methyl ketone
  • 4-methoxyphenylmethylketone
  • Acetanisol
  • Acetophenone, p-methoxy-
  • Ethanone, 1-(4-methoxyphenyl)-
  • PARA-ACETANISOLE
  • ACETANISOL (ACANTHON, METHOXY-ACETOPHENON)
  • 4-METHOXY ACETO PHENOL
  • 39) PARA METHOXY ACETOPHENONE
  • p-METHOXYACETOPHENONE pure
  • 4μ-Methoxyacetophenone, 4-Acetylanisole
  • P-METHOXYACETOPHENONE
  • 1-Acetyl-4-methoxybenzene
  • p-Methoxyacetophenone, synthesis grade
  • Acetanisole,4′-Methoxyacetophenone, 4-Acetylanisole
  • Nippon Hawthorn Fruit
  • 4-Acetylanisole, 1-(4-methoxyphenyl)ethan-1-one
  • 4'-Methoxyacetophenone,98%
  • 4-Acetoanisole 4-Acetylanisole
  • NSC 209523
  • NSC 5601
  • The Methoxy acetophenone