CHLOROTRIANISENE

Product Name: CHLOROTRIANISENE
CAS No.: 569-57-3
Chemical Name: CHLOROTRIANISENE
Synonyms: CSVP;Tace;ADA17;CD156b;Metace;Rianil;ADAM 17;Anisene;Tace-fn;Merbentul
CBNumber: CB9321078
Molecular Formula: C23H21ClO3
Formula Weight: 380.86
MOL File: 569-57-3.mol

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CHLOROTRIANISENE Property

Melting point:: 114-116°
Boiling point:: 496.07°C (rough estimate)
Density: 1.1010 (rough estimate)
refractive index: 1.4585 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥16.1 mg/mL in DMSO
form: solid
color: Off-white to light yellow
EPA Substance Registry System: Chlorotrianisene (569-57-3)

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Safety

WGK Germany: 3
RTECS: KV0600000
Hazardous Substances Data: 569-57-3(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Usbiological

Product number: 384536
Product name: TACE
Packaging: 96Tests
Price: $729
Updated: 2021/12/16

ApexBio Technology

Product number: B5912
Product name: Chlorotrianisene
Packaging: 25mg
Price: $1200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0001964
Product name: CHLOROTRIANISENE
Purity: 95.00%
Packaging: 25G
Price: $3335.06
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb529241
Product name: ADAM17
Packaging: 10μg
Price: $387.6
Updated: 2021/12/16

ChemScene

Product number: CS-0020308
Product name: Chlorotrianisene
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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CHLOROTRIANISENE Chemical Properties,Usage,Production

Originator

TACE,Merrell ,US ,1952

Uses

Estrogen.

Uses

Chlorotrianisene USP (TACE) is used to treat Androgen dependent carcinoma of the prostate.

Definition

ChEBI: Chlorotrianisene is a chloroalkene. It has a role as an estrogen receptor modulator, an antineoplastic agent and a xenoestrogen. It derives from a hydride of a stilbene.

Manufacturing Process

The following method is described in US Patent 2,430,891. To a solution of 10 parts of tris-p-methoxyphenyl ethylene in 35 to 40 parts of carbon tetrachloride is added a solution of 2.0 parts of chlorine in 50 parts of carbon tetrachloride, with stirring, and over a period of ? hour. The carbon tetrachloride is then removed by distillation on a steam bath and the residual oil is recrystallized from 250 to 400 parts of methanol, decolorizing with charcoal or the like if necessary. Tris-p-methoxyphenyl chloroethylene is obtained in a yield of 65 to 75%. It melts at 113° to 114°C.

brand name

Tace (Sanofi Aventis).

Therapeutic Function

Estrogen

General Description

Small white crystals or white powder. Softens at 226°F. Odorless.

Air & Water Reactions

Sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

CHLOROTRIANISENE may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. May react exothermically with both acids and bases. Various catalysts (such as acids) or initiators can cause very exothermic addition polymerization reactions.

Fire Hazard

Flash point data for CHLOROTRIANISENE are not available. CHLOROTRIANISENE is probably combustible.

Biological Activity

ed50: 2.0 μmglandular kallikrein, a trypsin-like serine protease, has been identified as a major estrogen-induced protein in the rat anterior pituitary. this induction appears to be mediated by increased gene expression since glandular kallikrein mrna is also estrogen-induced. chlorotrianisene is classified as an estrogen agonist.

in vitro

the ed50 of chlorotrianisene were lowered by 3.9-fold. chlorotrianisene inhibited the growth of both p388 and p388/adr cells in a concentration-dependent manner [1].

in vivo

chlorotrianisene markedly varied in its ability to elicit agonist responses on the three measures. on uterine weight and anterior pituitary prolactin, chlorotrianisene behaved as partial agonists. chlorotrianisene also exhibited strikingly less agonist activity on glandular kallikrein than on prl or the uterus. further, the small agonist activity of chlorotrianisene on glandular kallikrein induction differed from that on the uterus or prolactin [2].

References

[1] ramu a, glaubiger d, fuks z. reversal of acquired resistance to doxorubicin in p388 murine leukemia cells by tamoxifen and other triparanol analogues. cancer res. 1984 oct;44(10):4392-5.
[2] powers ca, hatala ma, pagano pj. differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene. mol cell endocrinol. 1989 sep;66(1):93-100.
[3] nulsen ro, carmon wb, hendrick ho. tace (chlorotrianisene), a new estrogen for inhibition of lactation. am j obstet gynecol. 1953 may;65(5):1048-51.

CHLOROTRIANISENE Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone Grignard reagent Styrene Anisole Chloroacetyl chloride Anisic acid

Preparation Products

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CHLOROTRIANISENE Suppliers

China 75 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 19 Global 101

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View Lastest Price from CHLOROTRIANISENE manufacturers

Career Henan Chemical Co

Product: CHLOROTRIANISENE 569-57-3
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-21

569-57-3, CHLOROTRIANISENERelated Search:

Dapoxetine Levonorgestrel DEUTERIUM DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 4,4'-Ethylidenebisphenol TRANS-4-HYDROXYSTILBENE 4-Methoxybenzylchloride Triphenylethylene CHLOROTRIANISENE 4,4'-DIMETHOXYSTILBENE 1-CHLORO-2-METHYL-1-PROPENE 4,4'-DIHYDROXYSTILBENE 4-METHOXYSTILBENE BETA-CHLOROSTYRENE (Z)-2-CHLORO-2-BUTENE 1-(-2-CHLORO-VINYL)-4-METHOXY-BENZENE 4,4'-(Z)-ETHENE-1,2-DIYLDIPHENOL

CHLOROTRIANISENE

chlorotris(4-methoxyphenyl)ethylene

Chlortrianisoestrol

1,1',1''-(1-Chloro-1,2,2-ethenetriyl)tris[4-methoxybenzene]

1-Chloro-1,2,2-tris(4-methoxyphenyl)ethene

1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene

1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxy-benzene

Chlorotrianisene (1 g)

ADA17

ADAM 17

Anti-ADAM 17, C-Terminal antibody produced in rabbit

CD156b antigen

CSVP

CD156b

Disintegrin and metalloproteinase domain-containing protein 17

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-benzen

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy-benzen

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene)

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene]

1-[2-Chloro-1,2-bis(4-methoxyphenyl)vinyl]-4-methoxybenzene

Anisene

Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris*4-methoxy-

Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-

Chloortrianisestrol

Chlorestrolo

chlorotrianisenecrystalline

Chlorotrianisine

Chlorotrianizen

chlorotris(p-methoxyphenyl)-ethylen

Chlorotris(p-methoxyphenyl)ethylene

Chlorotrisin

Chlortrianisen

Chlortrianisestrol

Chlortrianizen

Clorestrolo

Clorotrisin

Ethylene, chlorotris(p-methoxyphenyl)-

Hormonisene

Khlortrianizen

Merbentul

Metace

Nsc-10108

Rianil

Tace

Tace-fn

Trianisestrol

Tri-p-anisylchloroethylene

Tris(p-methoxyphenyl)chloroethylene

Tris-(p-methoxyphenyl)ethylene

Chlorotrianisene-d9

4,4',4''-(2-chloroethene-1,1,2-triyl)tris(Methoxybenzene)

Snake venom-like protease

TACE, human

TNF-alpha convertase

Anti-ADAM 17 (Cleaved-Arg215) antibody produced in rabbit

1,1',1''-(2-Chloro-1,1,2-ethenetriyl)tris(4-methoxybenzene)

1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene)

1,1',1(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene]