CHLOROTRIANISENE

ChemicalBook > CAS DataBase List > CHLOROTRIANISENE

Product Name: CHLOROTRIANISENE
CAS No.: 569-57-3
Chemical Name: CHLOROTRIANISENE
Synonyms: CSVP;Tace;ADA17;CD156b;Metace;Rianil;ADAM 17;Anisene;Tace-fn;Merbentul
CBNumber: CB9321078
Molecular Formula: C23H21ClO3
Formula Weight: 380.86
MOL File: 569-57-3.mol

Less

CHLOROTRIANISENE Property

Melting point:: 114-116°
Boiling point:: 496.07°C (rough estimate)
Density: 1.1010 (rough estimate)
refractive index: 1.4585 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥16.1 mg/mL in DMSO
form: solid
color: Off-white to light yellow
EPA Substance Registry System: Chlorotrianisene (569-57-3)

Less

Safety

WGK Germany: 3
RTECS: KV0600000
Hazardous Substances Data: 569-57-3(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

Less

N-Bromosuccinimide Price

Usbiological

Product number: 384536
Product name: TACE
Packaging: 96Tests
Price: $729
Updated: 2021/12/16

AK Scientific

Product number: 1046CA
Product name: Chlorotrianisene
Packaging: 25mg
Price: $97
Updated: 2021/12/16

ChemScene

Product number: CS-0020308
Product name: Chlorotrianisene
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0020308
Product name: Chlorotrianisene
Packaging: 10mg
Price: $250
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0001964
Product name: CHLOROTRIANISENE
Purity: 95.00%
Packaging: 10MG
Price: $255.15
Updated: 2021/12/16

Less

CHLOROTRIANISENE Chemical Properties,Usage,Production

Originator

TACE,Merrell ,US ,1952

Uses

Estrogen.

Uses

Chlorotrianisene USP (TACE) is used to treat Androgen dependent carcinoma of the prostate.

Definition

ChEBI: Chlorotrianisene is a chloroalkene. It has a role as an estrogen receptor modulator, an antineoplastic agent and a xenoestrogen. It derives from a hydride of a stilbene.

Manufacturing Process

The following method is described in US Patent 2,430,891. To a solution of 10 parts of tris-p-methoxyphenyl ethylene in 35 to 40 parts of carbon tetrachloride is added a solution of 2.0 parts of chlorine in 50 parts of carbon tetrachloride, with stirring, and over a period of ? hour. The carbon tetrachloride is then removed by distillation on a steam bath and the residual oil is recrystallized from 250 to 400 parts of methanol, decolorizing with charcoal or the like if necessary. Tris-p-methoxyphenyl chloroethylene is obtained in a yield of 65 to 75%. It melts at 113° to 114°C.

brand name

Tace (Sanofi Aventis).

Therapeutic Function

Estrogen

General Description

Small white crystals or white powder. Softens at 226°F. Odorless.

Air & Water Reactions

Sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

CHLOROTRIANISENE may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. May react exothermically with both acids and bases. Various catalysts (such as acids) or initiators can cause very exothermic addition polymerization reactions.

Fire Hazard

Flash point data for CHLOROTRIANISENE are not available. CHLOROTRIANISENE is probably combustible.

Biological Activity

ed50: 2.0 μmglandular kallikrein, a trypsin-like serine protease, has been identified as a major estrogen-induced protein in the rat anterior pituitary. this induction appears to be mediated by increased gene expression since glandular kallikrein mrna is also estrogen-induced. chlorotrianisene is classified as an estrogen agonist.

in vitro

the ed50 of chlorotrianisene were lowered by 3.9-fold. chlorotrianisene inhibited the growth of both p388 and p388/adr cells in a concentration-dependent manner [1].

in vivo

chlorotrianisene markedly varied in its ability to elicit agonist responses on the three measures. on uterine weight and anterior pituitary prolactin, chlorotrianisene behaved as partial agonists. chlorotrianisene also exhibited strikingly less agonist activity on glandular kallikrein than on prl or the uterus. further, the small agonist activity of chlorotrianisene on glandular kallikrein induction differed from that on the uterus or prolactin [2].

References

[1] ramu a, glaubiger d, fuks z. reversal of acquired resistance to doxorubicin in p388 murine leukemia cells by tamoxifen and other triparanol analogues. cancer res. 1984 oct;44(10):4392-5.
[2] powers ca, hatala ma, pagano pj. differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene. mol cell endocrinol. 1989 sep;66(1):93-100.
[3] nulsen ro, carmon wb, hendrick ho. tace (chlorotrianisene), a new estrogen for inhibition of lactation. am j obstet gynecol. 1953 may;65(5):1048-51.

CHLOROTRIANISENE Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone Grignard reagent Styrene Anisole Chloroacetyl chloride Anisic acid

Preparation Products

Less

CHLOROTRIANISENE Suppliers

China 75 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 19 Global 101

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Moltt Biocem Co., Ltd.

Tel: +86-21-38682181 15900741819
Fax: +86-21-38682181
Country: China
ProdList: 282
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2045
Advantage: 56

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Yunpun industrial Co.,Ltd

Tel: 21-61726900 15202122459
Fax: +86-21-60277507
Email: sales@yunpun.com
Country: China
ProdList: 498
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Nanjing Haolv Biotechnology Co.,Ltd

Tel: 025-84622273 17361806303
Email: 3004208264@qq.com
Country: China
ProdList: 3021
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 10058
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39894
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
Email: 422450190@qq.com
Country: China
ProdList: 10361
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7973
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10002
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Nantong Feiyu Biological Technology CO.,LTD

Tel: 0513-68819626; 15152877458
Fax: 0513-68669626
Email: feiyubio@163.com
Country: China
ProdList: 4819
Advantage: 58

Yancheng Tongming Biotechnology Co., Ltd.

Tel: 15195160625
Email: 2863565288@qq.com
Country: China
ProdList: 5192
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62163
Advantage: 58

Shanghai Yaji Biological Technology Co., Ltd.

Tel: 021-34661275 15301693058
Email: yajikit@163.com
Country: China
ProdList: 9670
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 15229059051
Email: 1027@dideu.com
Country: China
ProdList: 9992
Advantage: 58

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com
Country: China
ProdList: 18478
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Shanghai Huzhen Industrial Co., LTD

Tel: 021-60345367 13916550749
Email: sales@shzbio.com
Country: China
ProdList: 9966
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Biolab Reagents

Tel: 027-65279366 18162686757
Email: products@biolabreagent.com
Country: China
ProdList: 9818
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 15221441005
Email: lihua@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 4997
Advantage: 58

ACROBiosystems

Tel: 18514007688
Email: jiaxin.zhao@acrobiosystems.com
Country: China
ProdList: 1164
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

Wuhan WinYuanBei Trading Company

Tel: 86-13349903920; 13349903920
Fax: -
Email: 869523959@qq.com
Country: China
ProdList: 9693
Advantage: 58

bioleaper

Tel: 18601717983
Email: guojing@bioleaper.com
Country: China
ProdList: 5616
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9272
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 70071
Advantage: 58

Less

View Lastest Price from CHLOROTRIANISENE manufacturers

Career Henan Chemical Co

Product: CHLOROTRIANISENE 569-57-3
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-21

569-57-3, CHLOROTRIANISENERelated Search:

Dapoxetine Levonorgestrel DEUTERIUM DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 4,4'-Ethylidenebisphenol TRANS-4-HYDROXYSTILBENE 4-Methoxybenzylchloride Triphenylethylene CHLOROTRIANISENE 4,4'-DIMETHOXYSTILBENE 1-CHLORO-2-METHYL-1-PROPENE 4,4'-DIHYDROXYSTILBENE 4-METHOXYSTILBENE BETA-CHLOROSTYRENE (Z)-2-CHLORO-2-BUTENE 1-(-2-CHLORO-VINYL)-4-METHOXY-BENZENE 4,4'-(Z)-ETHENE-1,2-DIYLDIPHENOL

CHLOROTRIANISENE

chlorotris(4-methoxyphenyl)ethylene

Chlortrianisoestrol

1,1',1''-(1-Chloro-1,2,2-ethenetriyl)tris[4-methoxybenzene]

1-Chloro-1,2,2-tris(4-methoxyphenyl)ethene

1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene

1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxy-benzene

Chlorotrianisene (1 g)

ADA17

ADAM 17

Anti-ADAM 17, C-Terminal antibody produced in rabbit

CD156b antigen

CSVP

CD156b

Disintegrin and metalloproteinase domain-containing protein 17

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-benzen

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy-benzen

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene)

1,1’,1’’-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene]

1-[2-Chloro-1,2-bis(4-methoxyphenyl)vinyl]-4-methoxybenzene

Anisene

Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris*4-methoxy-

Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-

Chloortrianisestrol

Chlorestrolo

chlorotrianisenecrystalline

Chlorotrianisine

Chlorotrianizen

chlorotris(p-methoxyphenyl)-ethylen

Chlorotris(p-methoxyphenyl)ethylene

Chlorotrisin

Chlortrianisen

Chlortrianisestrol

Chlortrianizen

Clorestrolo

Clorotrisin

Ethylene, chlorotris(p-methoxyphenyl)-

Hormonisene

Khlortrianizen

Merbentul

Metace

Nsc-10108

Rianil

Tace

Tace-fn

Trianisestrol

Tri-p-anisylchloroethylene

Tris(p-methoxyphenyl)chloroethylene

Tris-(p-methoxyphenyl)ethylene

Chlorotrianisene-d9

4,4',4''-(2-chloroethene-1,1,2-triyl)tris(Methoxybenzene)

Snake venom-like protease

TACE, human

TNF-alpha convertase

Anti-ADAM 17 (Cleaved-Arg215) antibody produced in rabbit

1,1',1''-(2-Chloro-1,1,2-ethenetriyl)tris(4-methoxybenzene)

1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)-tris(4-methoxybenzene)

1,1',1(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene]