2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine

Product Name: 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
CAS No.: 7139-02-8
Chemical Name: 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
Synonyms: Einecs 230-437-4;Dipyridamole EP G;Dipyridamole Impurity 7;Dipyridamole Impurity 7（Dipyridamole EP Impurity G）;2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine;2,6-dichloro-4,8-dipiperidinyl-pyrimido[5,4-d]pyrimidine;PyriMido[5,4-d]pyriMidine,2,6-dichloro-4,8-di-1-piperidinyl-;2,6-dichloro-4,8-bis(1-piperidinyl)pyrimido[5,4-d]pyrimidine;2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine;2,6-Dichloro-4,8-di-(piperidin-l-yl)pyrimido[5,4-d] pyrimidine
CBNumber: CB41453863
Molecular Formula: C16H20Cl2N6
Formula Weight: 367.28
MOL File: 7139-02-8.mol

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2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Property

Melting point:: 249-251℃
Boiling point:: 504.1±50.0 °C(Predicted)
Density: 1.386±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly)
form: Solid
pka: 2.00±0.30(Predicted)
color: Pale Yellow to Light Yellow
InChI: InChI=1S/C16H20Cl2N6/c17-15-20-12-11(13(21-15)23-7-3-1-4-8-23)19-16(18)22-14(12)24-9-5-2-6-10-24/h1-10H2
InChIKey: PCVJQTVUJJJSRQ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(N2CCCCC2)=C2N=C(Cl)N=C(N3CCCCC3)C2=N1
LogP: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D434265
Product name: 2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging: 250mg
Price: $95
Updated: 2021/12/16

TRC

Product number: D434265
Product name: 2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging: 5g
Price: $475
Updated: 2021/12/16

TRC

Product number: D434265
Product name: 2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging: 25g
Price: $970
Updated: 2021/12/16

AK Scientific

Product number: 1084AC
Product name: 2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine
Packaging: 5g
Price: $109
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21623
Product name: 2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging: 10mg
Price: $139.8
Updated: 2021/12/16

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2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

An antitumor nucleoside pyrimido pyrimidine.

Synthesis

110-89-4

32980-71-5

7139-02-8

General procedure for the synthesis of 2,6-dichloro-4,8-dipiperidinosubstituted pyrimido[5,4-d]pyrimidines from hexahydropyridine and perchloropyrimido[5,4-d]pyrimidines: perchloropyrimido[5,4-d]pyrimidines (13.1 g, 48.9 mmol), piperidines, CuI (0.28 g, 1.5 mmol) and Cs2CO3 (16.0 g, 48.9 mmol) were added to a 250mL two-necked flask. 100 mL of nitrobenzene was added as reaction solvent and the reaction was carried out at 180°C for 16 h under nitrogen protection. After completion of the reaction, the nitrobenzene solvent was removed by distillation under reduced pressure. Purification by column chromatography using a solvent mixture of petroleum ether (PE) and dichloromethane (DCM) (6:1, v/v) gave 17.0 g of solid product in 95.0% yield and 99% selectivity.

References

[1] Patent: CN106946887, 2017, A. Location in patent: Paragraph 0035; 0036; 0037
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 20, p. 4905 - 4922
[3] Medicinal Chemistry Research, 1996, vol. 6, # 1, p. 61 - 67
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3906 - 3920
[5] Patent: CN108069972, 2018, A. Location in patent: Paragraph 0005; 0017

2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

5-AMINOOROTIC ACID Phosphorus oxitrichloride Urea 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine

Preparation Products

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2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Suppliers

Canada 1 China 97 France 1 India 5 United Kingdom 1 United States 6 Global 111

Shanghai Dongyue Biochem Co.,Ltd.

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View Lastest Price from 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine 7139-02-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

Career Henan Chemical Co

Product: 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine 7139-02-8
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

7139-02-8, 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidineRelated Search:

Dipyridamole Mono-O-b-D-glucuronide 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Dipyridamole 2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol Piperidinylpiperidine 2,2',2'',2'''-[[4-[(2-Hydroxyethyl)aMino]-8-(1-piperidinyl)pyriMido[5,4-d]pyriMidine-2,6-diyl]dinitrilo]tetrakisethanol (DipyridaMole IMpurity) 4,8-dichloro-2,6-dipiperidinopyrimido[5,4-d]pyrimidine Dipyridamole Tripiperidine 6-Des(diethanolamino)-6-chloro Dipyridamole Dipyridamole Tri(diethanolamine) Desethanol Dipyridamole 2-CHLORO-4-PIPERIDIN-1-YL-PYRIMIDINE 2,6-Dichloro-4,8-(dipiperidino-D20)-pyrimido[5,4-d]pyrimidine 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine

2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine

2,6-DICHLORO-4,8-DI-1-PIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINEDIPYRIDAMOLE

Einecs 230-437-4

PyriMido[5,4-d]pyriMidine,2,6-dichloro-4,8-di-1-piperidinyl-

2,6-dichloro-4,8-dipiperidinyl-pyrimido[5,4-d]pyrimidine

2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine

2,6-dichloro-4,8-bis(1-piperidinyl)pyrimido[5,4-d]pyrimidine

Dipyridamole Impurity 7（Dipyridamole EP Impurity G）

Dipyridamole EP Impurity GQ: What is Dipyridamole EP Impurity G Q: What is the CAS Number of Dipyridamole EP Impurity G Q: What is the storage condition of Dipyridamole EP Impurity G Q: What are the applications of Dipyridamole EP Impurity G

2,6-Dichloro-4,8-di-(piperidin-l-yl)pyrimido[5,4-d] pyrimidine

2,6-dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine (DCDPP)

Dipyridamole Impurity 7

2,6-Dichloro-4,8-Dipiperidinyl-Pyrimido[5,4-D]Pyrimidine(Dipyridamole Intermediate)

Dipyridamole EP G

7139-02-8

1913545

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