Pivaloyl chloride
- Product Name
- Pivaloyl chloride
- CAS No.
- 3282-30-2
- Chemical Name
- Pivaloyl chloride
- Synonyms
- PVCL;pivaloyl;TRIMETHYLACETYL CHLORIDE;PIVALYL CHLORIDE;PIVALIC ACID CHLORIDE;2,2-DIMETHYLPROPIONYL CHLORIDE;2,2-Dimethyl-propanoyl chloride;221-921-6;Pivalolyl chloride;PivCl
- CBNumber
- CB6477301
- Molecular Formula
- C5H9ClO
- Formula Weight
- 120.58
- MOL File
- 3282-30-2.mol
Pivaloyl chloride Property
- Melting point:
- -56 °C
- Boiling point:
- 105-106 °C(lit.)
- Density
- 0.980 g/mL at 20 °C
- vapor density
- >1 (vs air)
- vapor pressure
- 36 mm Hg ( 20 °C)
- refractive index
- n20/D 1.412(lit.)
- Flash point:
- 48 °F
- storage temp.
- Store below +30°C.
- solubility
- Miscible with acetonitrile.
- form
- Liquid
- color
- Clear almost colorless to light pink
- explosive limit
- 1.9-7.4%(V)
- Water Solubility
- Hydrolysis
- Sensitive
- Moisture Sensitive
- BRN
- 385668
- Stability:
- Hygroscopic, Moisture Sensitive, Volatile
- InChI
- 1S/C5H9ClO/c1-5(2,3)4(6)7/h1-3H3
- InChIKey
- JVSFQJZRHXAUGT-UHFFFAOYSA-N
- LogP
- 1.680 (est)
- CAS DataBase Reference
- 3282-30-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanoyl chloride, 2,2-dimethyl-(3282-30-2)
- EPA Substance Registry System
- Propanoyl chloride, 2,2-dimethyl- (3282-30-2)
Safety
- Hazard Codes
- F,T+,T
- Risk Statements
- 11-14-22-26-34-23
- Safety Statements
- 16-26-36/37/39-45-38-28A
- RIDADR
- UN 2438
- WGK Germany
- 1
- F
- 9-19
- Autoignition Temperature
- 455°C
- TSCA
- TSCA listed
- HazardClass
- 6.1
- PackingGroup
- I
- HS Code
- 29159080
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Acute Tox. 2 Inhalation
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 2
Met. Corr. 1
Skin Corr. 1B
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H290May be corrosive to metals
H302Harmful if swallowed
H313May be harmful in contact with skin
H314Causes severe skin burns and eye damage
H330Fatal if inhaled
H370Causes damage to organs
H402Harmful to aquatic life
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P234Keep only in original container.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P390Absorb spillage to prevent material damage.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T72605
- Product name
- Trimethylacetyl chloride
- Purity
- 99%
- Packaging
- 5ml
- Price
- $28.9
- Updated
- 2026/04/30
- Product number
- T72605
- Product name
- Trimethylacetyl chloride
- Purity
- 99%
- Packaging
- 100ml
- Price
- $35.6
- Updated
- 2026/04/30
- Product number
- 8.01276
- Product name
- Pivaloyl chloride
- Purity
- for synthesis
- Packaging
- 250ML
- Price
- $46.2
- Updated
- 2022/05/15
- Product number
- T72605
- Product name
- Trimethylacetyl chloride
- Purity
- 99%
- Packaging
- 500ml
- Price
- $90.1
- Updated
- 2026/04/30
- Product number
- D478010
- Product name
- 2,2-DimethylpropanoylChloride
- Packaging
- 100mL
- Price
- $135
- Updated
- 2021/12/16
Pivaloyl chloride Chemical Properties,Usage,Production
Chemical Properties
Colorless to yellow liquid
Uses
Widely used N-acylating agent for amines,1 Schiff bases,2 and pyrrolidinones3 as well as O-acylating agent for alcohols,4 lactones,5 and saccharides.6
Uses
Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 4569, 1988 DOI: 10.1016/S0040-4039(00)80549-3
General Description
Colorless fuming liquid with a pungent odor. Boiling point 105-106°F. Density 0.979 g / cm3. Flash point 48°F (8°C). Very toxic by inhalation, ingestion or skin absorption. Fumes irritate the eyes and mucous membranes. Corrosive to most metals and tissue.
Air & Water Reactions
Highly flammable. Fumes in air. Reacts vigorously and exothermically with water to form trimethylacetic acid and corrosive hydrochloric acid; both acids corrode metals and tissue [AAR 1991].
Reactivity Profile
Pivaloyl chloride is acidic. Incompatible with bases (including amines), strong oxidizing agents, and alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and Explosibility
Flammable
Safety Profile
A corrosive irritant to skin, eyes, and mucous membranes. The liquid is flammable when exposed to heat, flame, or oxiduers. When heated to decomposition it emits toxic fumes of Cl-.
Purification Methods
First check the IR to see if OH bands are present. If absent, or present in small amounts, then redistil it under a moderate vacuum. If present in large amounts then treat it with oxalyl chloride or thionyl chloride and reflux for 2-3hours, evaporate and distil the residue. Strongly LACHRYMATORY -work in a fumecupboard. Store it in sealed ampoules under N2. [Traynham & Battiste J Org Chem 22 1551 1957, Grignard reactions: Whitmore et al. J Am Chem Soc 63 647 1941, Beilstein 2 IV 912.]
Toxics Screening Level
The initial threshold screening level (ITSL) for pivaloyl chloride (also known as trimethylacetyl chloride) is 8 μg/m3 with annual averaging time.
Pivaloyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pivaloyl chloride manufacturers
- Product
- Pivaloyl chloride 3282-30-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- Pivaloyl Chloride 3282-30-2
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300 Tons/ year
- Release date
- 2019-12-25
- Product
- Trimethylacetyl 3282-30-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-09-11