ChemicalBook > CAS DataBase List > Pivaloyl chloride

Pivaloyl chloride

Product Name
Pivaloyl chloride
CAS No.
3282-30-2
Chemical Name
Pivaloyl chloride
Synonyms
PVCL;pivaloyl;221-921-6;JACS-3282-30-2;Trimethylacetyl;Pivaloylchlorid;Pyvaloylchloride;PIVALYL CHLORIDE;Pivaloyl chlorode;PIVALOYL CHLORIDE
CBNumber
CB6477301
Molecular Formula
C5H9ClO
Formula Weight
120.58
MOL File
3282-30-2.mol
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Pivaloyl chloride Property

Melting point:
-56 °C
Boiling point:
105-106 °C(lit.)
Density 
0.980 g/mL at 20 °C
vapor density 
>1 (vs air)
vapor pressure 
36 mm Hg ( 20 °C)
refractive index 
n20/D 1.412(lit.)
Flash point:
48 °F
storage temp. 
Store below +30°C.
solubility 
Miscible with acetonitrile.
form 
Liquid
color 
Clear almost colorless to light pink
explosive limit
1.9-7.4%(V)
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
385668
InChIKey
JVSFQJZRHXAUGT-UHFFFAOYSA-N
CAS DataBase Reference
3282-30-2(CAS DataBase Reference)
NIST Chemistry Reference
Propanoyl chloride, 2,2-dimethyl-(3282-30-2)
EPA Substance Registry System
Propanoyl chloride, 2,2-dimethyl- (3282-30-2)
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Safety

Hazard Codes 
F,T+,T
Risk Statements 
11-14-22-26-34-23
Safety Statements 
16-26-36/37/39-45-38-28A
RIDADR 
UN 2438 6.1/PG 1
WGK Germany 
1
9-19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
29159080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H330Fatal if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P320Specific treatment is urgent (see … on this label).

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T72605
Product name
Trimethylacetyl chloride
Purity
99%
Packaging
5ml
Price
$20.3
Updated
2021/03/22
Sigma-Aldrich
Product number
T72605
Product name
Trimethylacetyl chloride
Purity
99%
Packaging
100ml
Price
$20.4
Updated
2021/03/22
Alfa Aesar
Product number
A15051
Product name
Trimethylacetyl chloride, 98+%
Packaging
500ml
Price
$58.6
Updated
2021/03/22
Alfa Aesar
Product number
A15051
Product name
Trimethylacetyl chloride, 98+%
Packaging
100ml
Price
$18
Updated
2021/03/22
Sigma-Aldrich
Product number
T72605
Product name
Trimethylacetyl chloride
Purity
99%
Packaging
500ml
Price
$67
Updated
2021/03/22
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Pivaloyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

Widely used N-acylating agent for amines,1 Schiff bases,2 and pyrrolidinones3 as well as O-acylating agent for alcohols,4 lactones,5 and saccharides.6

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 4569, 1988 DOI: 10.1016/S0040-4039(00)80549-3

General Description

Colorless fuming liquid with a pungent odor. Boiling point 105-106°F. Density 0.979 g / cm3. Flash point 48°F (8°C). Very toxic by inhalation, ingestion or skin absorption. Fumes irritate the eyes and mucous membranes. Corrosive to most metals and tissue.

Air & Water Reactions

Highly flammable. Fumes in air. Reacts vigorously and exothermically with water to form trimethylacetic acid and corrosive hydrochloric acid; both acids corrode metals and tissue [AAR 1991].

Reactivity Profile

Pivaloyl chloride is acidic. Incompatible with bases (including amines), strong oxidizing agents, and alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

A corrosive irritant to skin, eyes, and mucous membranes. The liquid is flammable when exposed to heat, flame, or oxiduers. When heated to decomposition it emits toxic fumes of Cl-.

Purification Methods

First check the IR to see if OH bands are present. If absent, or present in small amounts, then redistil it under a moderate vacuum. If present in large amounts then treat it with oxalyl chloride or thionyl chloride and reflux for 2-3hours, evaporate and distil the residue. Strongly LACHRYMATORY -work in a fumecupboard. Store it in sealed ampoules under N2. [Traynham & Battiste J Org Chem 22 1551 1957, Grignard reactions: Whitmore et al. J Am Chem Soc 63 647 1941, Beilstein 2 IV 912.]

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Pivaloyl chloride Suppliers

Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546-
Fax
025-87193546
Email
chemweiao@163.com;
Country
China
ProdList
9076
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Speranza Chemical Co., Ltd.
Tel
0755-33122716 18688942810
Fax
0755-33122716
Email
sales@speranzachem.com
Country
China
ProdList
127
Advantage
50
Beijing Tianyukanghong Chemical Technology Co., Ltd.
Tel
010-57794770
Fax
010-60593781
Email
tianyukanghong@163.com
Country
China
ProdList
344
Advantage
55
Tianjin and Sinde Biotechnology Co., Ltd.
Email
sales_hxd@163.com;sales_hxd@163.com
Country
China
ProdList
121
Advantage
58
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6561
Advantage
50
Kunshan zhonglaite Trading Co., Ltd
Tel
0512-55170668- ;0512-50323806-
Email
26886897@qq.com;474293744@qq.com
Country
China
ProdList
1710
Advantage
58
Shanghai RC Chemicals Co. Ltd
Tel
86-21-50322175; 50322680;021-50322680-
Fax
86-21-50322176
Email
rcchemicals@vip.163.com;chad@rcc.net.cn
Country
China
ProdList
287
Advantage
55
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Pivaloyl chloride manufacturers

Speranza Chemical Co., Ltd.
Product
Pivaloyl Chloride 3282-30-2
Price
US $20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300 Tons/ year
Release date
2019-12-25
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Pivaloyl chloride 3282-30-2
Price
US $9.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2021-11-26
Shandong Luning Pharmaceutical Co., Ltd.
Product
Trimethylacetyl chloride 3282-30-2
Price
US $3500.00/T
Min. Order
1T
Purity
99%
Supply Ability
600T
Release date
2020-11-06

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