PIVALAMIDE

Product Name: PIVALAMIDE
CAS No.: 754-10-9
Chemical Name: PIVALAMIDE
Synonyms: NSC 17584;AKOS 94230;PIVALAMIDE;PIVALOYLAMINE;PIVALOYLAMIDE;PIVALIC AMIDE;Pivalamide>Neopentanamide;PIVALIC ACID AMIDE;TRIMETHYLACETAMIDE
CBNumber: CB5783553
Molecular Formula: C5H11NO
Formula Weight: 101.15
MOL File: 754-10-9.mol

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PIVALAMIDE Property

Melting point:: 154-157 °C (lit.)
Boiling point:: 212 °C (lit.)
Density: 0.903±0.06 g/cm3 (20 ºC 760 Torr)
refractive index: 1.4380 (estimate)
Flash point:: 212°C
storage temp.: Sealed in dry,Room Temperature
pka: 16.60±0.50(Predicted)
form: Crystalline Powder
color: White to very slightly yellow
BRN: 1742147
InChI: InChI=1S/C5H11NO/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)
InChIKey: XIPFMBOWZXULIA-UHFFFAOYSA-N
SMILES: C(N)(=O)C(C)(C)C
CAS DataBase Reference: 754-10-9(CAS DataBase Reference)
EPA Substance Registry System: Propanamide, 2,2-dimethyl- (754-10-9)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T71609
Product name: Trimethylacetamide
Purity: 98%
Packaging: 25g
Price: $93.6
Updated: 2025/07/31

TCI Chemical

Product number: P0819
Product name: Pivalamide
Purity: >98.0%(GC)(N)
Packaging: 25g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: P0819
Product name: Pivalamide
Purity: >98.0%(GC)(N)
Packaging: 100g
Price: $110
Updated: 2025/07/31

TCI Chemical

Product number: P0819
Product name: Pivalamide
Purity: >98.0%(GC)(N)
Packaging: 500g
Price: $606
Updated: 2024/03/01

TRC

Product number: T797263
Product name: 2,2,2-Trimethylacetamide
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

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PIVALAMIDE Chemical Properties,Usage,Production

Chemical Properties

WHITE TO VERY SLIGHTLY YELLOW CRYSTALLINE POWDER

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 4941, 1986 DOI: 10.1016/S0040-4039(00)85102-3

Synthesis

75-98-9

754-10-9

The general procedure for the synthesis of trimethylacetamide from pivalic acid is as follows: to a 10 mL THF colorless solution containing 75 mg (0.50 mmol) of 3-phenylpropionic acid 1a at 0 °C, 67 μL (0.70 mmol, 1.4 eq.) of ethyl chloroformate and 209 μL (1.5 mmol, 3.0 eq.) of triethylamine were added sequentially. The reaction mixture was stirred at 0 °C for 30 min before adding 0.75 mL of 1.0 M NH4Cl aqueous solution (0.75 mmol, 1.5 equiv). Stirring was continued at 0 °C for 30 min, followed by the addition of 5 mL of water. The reaction mixture was extracted with 30 mL of ethyl acetate and the aqueous layer was then extracted with 20 mL of ethyl acetate. The organic layers were combined, washed with 5 mL of brine and dried with anhydrous magnesium sulfate. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate) to give 72 mg (96% yield) of 3-phenylpropionamide 2a. Synthesis of trimethylacetamide 2d: 44 mg (87% yield) of a colorless solid was obtained; melting point: 105-108 °C; 1H NMR (400 MHz, CDCl3): δ1.23 (s, 9H, CH3*3), δ1.21 (br, 1H, 1H). 5.21 (br, 1H, NHA), 5.59 (br, 1H, NHB); 13C NMR (100MHz, CDCl3): δ 27.7,38.7,181.6; IR (KBr, vmax/cm-1): 3398 (CONH), 3205 (CONH), 2960 (CH3), 1653 (CON), 1653 (CON). 1624 (CON); HRMS (ESI-TOF): calculated value C5H11NONa(M+Na)+: 124.0733, measured value: 124.0723.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008, vol. 47, # 2, p. 315 - 318
[2] Chemistry Letters, 2008, vol. 37, # 12, p. 1191 - 1192
[3] Synthesis, 2003, # 2, p. 272 - 276
[4] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[5] Tetrahedron Letters, 2000, vol. 41, # 50, p. 9809 - 9813

PIVALAMIDE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Acetone Pivaloyl chloride Phosphorus pentoxide

Preparation Products

tert-Butylamine CEFTRIAXONE

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PIVALAMIDE Suppliers

Americas 1 Belgium 5 China 124 Europe 1 France 1 Germany 6 India 4 Japan 4 Switzerland 2 Ukraine 1 United Kingdom 13 United States 30 Global 192

Shanghai shallow overflow new Materials Co. , Ltd.

Tel: 86-18372897-544 18995560451
Email: 1308815138@qq.com
Country: China
ProdList: 489
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2809
Advantage: 65

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

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View Lastest Price from PIVALAMIDE manufacturers

Sach biotech Co.,Ltd

Product: Trimethylacetamide 754-10-9
Price: US $200.00-150.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kgs/month
Release date: 2024-07-09

Career Henan Chemical Co

Product: PIVALAMIDE 754-10-9
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

754-10-9, PIVALAMIDERelated Search:

Pivalic acid PYRITHYLDIONE Cytochalasin H PIVALAMIDE Aminoglutethimide oxyphenisatine di(acetate) 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE 5-ethyldihydro-5-(2-methylallyl)-2-thioxo-1H,5H-pyrimidine-4,6-dione 2-Ethyl-2-phenylmalonamide 5,5-DIETHYLBARBITURIC ACID SODIUM SALT Phenobarbital sodium ALPHA-METHYL-ALPHA-PROPYLSUCCINIMIDE 5-ETHYL-5-P-TOLYLBARBITURIC ACID 99+% 4-HYDROXYPHENOBARBITAL N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE ALPHA,ALPHA-DIMETHYL-BETA-METHYLSUCCINIMIDE DIHYDRO-5-PHENYL-5-PROPYL-4,6(1H,5H)-PYRIMIDINEDIONE ALPHA-METHYL-ALPHA-PHENYLSUCCINIMIDE

2,2-Dimethyl-propanamide

AKOS 94230

2,2,2-TRIMETHYLACETAMIDE

2,2-DIMETHYLPROPIONAMIDE

2,2-DIMETHYLPROPANOIC AMIDE

TRIMETHYLACETAMIDE

PIVALIC ACID AMIDE

PIVALIC AMIDE

PIVALAMIDE

PIVALOYLAMIDE

PIVALOYLAMINE

2,2-Dimethylpropanimidic acid

2,2,2-Trimethylacetamide, 98+%

Trimethylacetamide, 98+%

2,2-Dimethylpropionamide Pivaloylamide Trimethylacetamide

Neopentanamide

NSC 17584

Trimethylacetamide 98%

2,2-dimethyl-propanamid

2,2-Dimethyl-propinamide

2,2-Dimethylpropanamide

Propanamide, 2,2-dimethyl-

Pivalamide&gt

754-10-9

CH33CCONH2

Organic Building Blocks

Carbonyl Compounds

Building Blocks

Amides