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tert-Butylamine

Product Name
tert-Butylamine
CAS No.
75-64-9
Chemical Name
tert-Butylamine
Synonyms
TERTIARY BUTYL AMINE;T-BUTYLAMINE;erbumine;1,1-Dimethylethylamine;Trimethylaminomethane;2-Methyl-2-propanamine;2-AMINO-2-METHYLPROPANE;cp11093;tert-C4H9NH2;TERT-BUTYLAMINE
CBNumber
CB8854238
Molecular Formula
C4H11N
Formula Weight
73.14
MOL File
75-64-9.mol
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tert-Butylamine Property

Melting point:
-67 °C (lit.)
Boiling point:
46 °C (lit.)
Density 
0.696 g/mL at 25 °C (lit.)
vapor density 
2.5 (vs air)
vapor pressure 
5.7 psi ( 20 °C)
refractive index 
n20/D 1.377(lit.)
Flash point:
−36.4 °F
storage temp. 
Store below +30°C.
solubility 
water: miscible1000g/L at 25°C
form 
Liquid
pka
10.68(at 25℃)
color 
Clear
Odor
Like ammonia.
PH
12 (100g/l, H2O, 20℃)
explosive limit
1.5-9.2%(V)
Odor Threshold
0.17ppm
Water Solubility 
MISCIBLE
Sensitive 
Air Sensitive
Merck 
14,1545
BRN 
605267
Dielectric constant
4.3099999999999996
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents. Highly flammable.
CAS DataBase Reference
75-64-9(CAS DataBase Reference)
NIST Chemistry Reference
2-Propanamine, 2-methyl-(75-64-9)
EPA Substance Registry System
tert-Butylamine (75-64-9)
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Safety

Hazard Codes 
F,C,T
Risk Statements 
11-20/22-35-25-20-52/53
Safety Statements 
16-26-36/37/39-45-28A-61
RIDADR 
UN 3286 3/PG 2
WGK Germany 
1
RTECS 
EO3330000
2-10
Autoignition Temperature
716 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29211980
Hazardous Substances Data
75-64-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 80 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
100mL
Price
$35.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
500mL
Price
$47.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
1L
Price
$64.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01546
Product name
tert-Butylamine
Purity
for synthesis
Packaging
35kg
Price
$1430
Updated
2024/03/01
Sigma-Aldrich
Product number
391433
Product name
tert-Butylamine
Purity
≥99.5%
Packaging
100ml
Price
$98.9
Updated
2024/03/01
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tert-Butylamine Chemical Properties,Usage,Production

Chemical Properties

tert-Butylamine is a colorless liquid with a typical amine-like odor. It is one of the four isomeric amines of butane, the others being n-butylamine, sec-butylamine and isobutylamine. Butylamines are highly flammable, colorless liquids (n-turns yellow on standing) with ammoniacal or fishlike odors. tert-Butylamine is used in the preparation of insecticides, pharmaceuticals, oil additives, and rubber accelerators.

Uses

tert-butylamine is used as a precursor for the preparation of rubber accelerators, pharmaceuticals and dyes. It is employed in synthesis of N-tert-butyl-acetamide, isoquinolines, pyridines, decumbenine, sulfontes, sulfonamides and methyl beta-ketophosphonate. It is also used in the study the effect of amines in influencing atmospheric sulfuric acid - water nucleation, hydroamination of terminal alkynes and measuring the surface acidity of solid catalyst. It acts as an indicator molecule in the study of NMR -based pH determination method.

Preparation

tert-Butylamine is produced commercially by direct amination of isobutylene using zeolite catalysts:
NH3 + CH2=C(CH3)2 → H2NC(CH3)3
The Ritter reaction of isobutene with hydrogen cyanide is not useful because it produces too much waste.
(CH3)2C=CH2 + HCN + H2O → (CH3)3CNHCHO
(CH3)3CNHCHO + H2O → (CH3)3CNH2 + HCO2H
In the laboratory, it can be prepared by the hydrogenolysis of 2,2-dimethylethylenimine, or via tert-butylphthalimide.

Production Methods

tert-Butylamine is manufactured by reacting isobutylamine with sulfuric acid followed by cyanide to tert-butylformamide. Hydrolysis yields t-butylamine. It is used as a solvent and in organic syntheses.

Application

Tert-Butylamine is also used for the production of herbicides, i.e., terbacil and the triazines terbutylazine, terbumeton, and terbutryn and insecticides (e.g., diafenthiuron). A derivative has also been proposed as stabilizer for cosmetics.

Definition

ChEBI: Tert-butylamine is a primary aliphatic amine that is ethylamine substituted by two methyl groups at position 1. It is a conjugate base of a tert-butylammonium.

General Description

Tert-butylamine appears as a clear colorless liquid with an ammonia-like odor. Flash point 70°F. Less dense (at 6.2 lb / gal) than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Air & Water Reactions

Highly flammable. May be sensitive to air . Soluble in water.

Reactivity Profile

tert-Butylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Undergoes highly exothermic reaction with 2,2-dibromo-1,3-dimethylcyclopropanoic acid [J. Chem. Soc., 1, 1979, 2324].

Hazard

Skin irritant. Flammable, dangerous fire risk.

Health Hazard

Inhalation causes irritation of nose, mouth, and lungs. Ingestion causes irritation of mouth and stomach. Contact with liquid causes severe irritation of eyes and moderate irritation of skin.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire.

Safety Profile

Poison by ingestion. Moderately toxic to humans by inhalation. A corrosive liquid. See also n-BUTYLAMINE and AMINES. Very dangerous fire hazard when exposed to heat or flame. Very exothermic reaction with 2,2-dibromo-l,3 dimethylcyclopropanoic acid. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Alert: (n-isomer): Possible risk of forming tumors, suspected of causing genetic defects, suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (sec-isomer): Drug. n-Butylamine is used in pharmaceuticals; dyestuffs, rubber, chemicals, emulsifying agents; photography, desizing agents for textiles; pesticides, and synthetic agents. sec-Butylamine is used as a fungistate. tert-Butylamine is used as a chemical intermediate in the production of tert-Butylaminoethyl methacrylate (a lube oil additive); as an intermediate in the production of rubber and in rust preventatives and emulsion deterrents in petroleum products. It is used in the manufacture of several drugs

Shipping

UN1125 n-Butylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material. UN2014 Isobutylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material

Purification Methods

Dry it with KOH or LiAlH4, and/or distil it from CaH2 or BaO. [Beilstein 4 IV 657.]

Incompatibilities

May form explosive mixture with air. May accumulate static electrical charges, and may causeignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids, causing fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moisture. The tert-isomer will attack some forms of plastics

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner andscrubber. All federal, state, and local environmental regulations must be observed.

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tert-Butylamine Suppliers

Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516722 13701817765
Fax
021-33516776
Email
kaisaichem@163.com
Country
China
ProdList
4741
Advantage
58
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Shandong Jinyueyuan New Material Co. Ltd
Tel
18615187817
Email
2793152786@qq.com
Country
China
ProdList
393
Advantage
58
Shanghai Nolai Giant Chemical Co. , Ltd.
Tel
13012824065
Email
121597535@qq.com
Country
China
ProdList
190
Advantage
58
Shanghai Wohua Chemical Co., Ltd.
Tel
021-57681602-802 17302146015
Fax
57683062-808
Email
2851602437@qq.com
Country
China
ProdList
289
Advantage
58
Jiangsu Aowei New Materials Technology Co., Ltd
Tel
13335217656
Email
694153640@qq.com
Country
China
ProdList
205
Advantage
58
Shandong Yuxuan Chemical Products Co., Ltd
Tel
15865789333 18953919089
Email
2227167100@qq.com
Country
China
ProdList
50
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from tert-Butylamine manufacturers

Changde Changlian Chemical Co., Ltd.
Product
tert-Butylamine 75-64-9
Price
US $0.00/Kg/Drum
Min. Order
140KG
Purity
99%
Supply Ability
1000 tons
Release date
2020-07-14
Ningxia Jinhua Chemical Co.,Ltd
Product
Tert-butylamine 75-64-9
Price
US $0.00/Kg/Drum
Min. Order
140KG
Purity
99%
Supply Ability
1000 Tons
Release date
2020-07-14
Hebei Weibang Biotechnology Co., Ltd
Product
tert-Butylamine 75-64-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01

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