N-TERT-BUTYL-ALPHA-PHENYLNITRONE

Product Name: N-TERT-BUTYL-ALPHA-PHENYLNITRONE
CAS No.: 3376-24-7
Chemical Name: N-TERT-BUTYL-ALPHA-PHENYLNITRONE
Synonyms: PBN;N-tert-Butyl-α-phenylnitrone;N-tert-Butyl-α-phenylnitrone;2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide;Butylphenylnitrone;Phenyl N-t-butylnitrone;PHENYL-TERT-BUTYLNITRONE;N-T-BUTYL-A-PHENYLNITRONE;PHENYL N-TERT-BUTYLNITRONE;c-phenyl-n-tert-butylnitrone
CBNumber: CB8469861
Molecular Formula: C11H15NO
Formula Weight: 177.24
MOL File: 3376-24-7.mol

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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Property

Melting point:: 73-74 °C(lit.)
Boiling point:: 283℃
Density: 0.990
refractive index: 1.5480 (estimate)
Flash point:: 119℃
storage temp.: Store at <= 20°C.
solubility: DMSO: soluble
form: powder
pka: 1.50±0.53(Predicted)
color: white
Water Solubility: Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
Merck: 14,7056
BRN: 2044028
CAS DataBase Reference: 3376-24-7(CAS DataBase Reference)
EPA Substance Registry System: 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TX1760000
F: 10
TSCA: Yes
HS Code: 2929 90 00

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 80126
Product name: N-tert-Butyl-α-phenylnitrone
Purity: for ESR-spectroscopy
Packaging: 1g
Price: $281
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.41179
Product name: N-tert-Butyl-α-phenylnitrone
Purity: for synthesis
Packaging: 1g
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: 203995
Product name: N-tert-Butyl-α-phenylnitrone
Purity: Most commonly-used free radical trap.
Packaging: 500mg
Price: $111
Updated: 2024/03/01

TCI Chemical

Product number: B1701
Product name: N-tert-Butyl-alpha-phenylnitrone
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $68
Updated: 2024/03/01

TCI Chemical

Product number: B1701
Product name: N-tert-Butyl-alpha-phenylnitrone
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $218
Updated: 2024/03/01

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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Chemical Properties,Usage,Production

Chemical Properties

white to light beige fine crystalline powder

Uses

N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Uses

N-tert-Butyl-α-phenylnitrone has been used:

as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)

Uses

Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.

Synthesis Reference(s)

Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6

General Description

Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Biochem/physiol Actions

Product does not compete with ATP.

Purification Methods

Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.]

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Preparation Products And Raw materials

Raw materials

ZINC Acetonitrile Ethanol Sodium sulfate Toluene 3-Chloroperoxybenzoic acid Benzaldehyde Diethyl ether Benzene Ethyl acetate Hydrochloric acid Sodium bicarbonate Potassium permanganate Acetic acid tert-Butylamine PETROLEUM ETHER

Preparation Products

2-METHYL-N-(PHENYLMETHYLENE)-2-PROPYLAMINE

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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Suppliers

Americas 1 Belgium 1 Canada 1 China 114 Europe 1 Germany 4 India 4 Japan 2 Switzerland 3 United Kingdom 5 United States 22 Global 158

Hubei Jiuchang New Material Technology Co., Ltd

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View Lastest Price from N-TERT-BUTYL-ALPHA-PHENYLNITRONE manufacturers

Shanghai UCHEM Inc.

Product: N-tert-Butyl-α-phenylnitrone 3376-24-7
Price: US $79.00-519.00/g
Min. Order: 5g
Purity: 0.97
Supply Ability: 25kg
Release date: 2023-12-27

Shaanxi Dideu Medichem Co. Ltd

Product: N-TERT-BUTYL-ALPHA-PHENYLNITRONE 3376-24-7
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-19

Career Henan Chemical Co

Product: 3376-24-7 3376-24-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

3376-24-7, N-TERT-BUTYL-ALPHA-PHENYLNITRONERelated Search:

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine N-TERT-BUTYL-ALPHA-PHENYLNITRONE tert-Butylamine NITRON PTIO CARBOXY-PTIO 2-(4-NITROPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL N-TERT-BUTYL-D9-PHENYL-D5-NITRONE N-TERT-BUTYL-ALPHA-(2-SULFOPHENYL)NITRO& BENZYLIDENE(2-HYDROXYIMINO-1,1-DIMETHYLETHYL)AMMONIUMOLATE N-(1-CYANO-1-METHYLETHYL)-A-PHENYLNITRONE 5-AMINO-4,4-DIMETHYL-2-PHENYL-4H-IMIDAZOLE-3-OXIDE 2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, NA N-TERT-BUTYL-ALPHA-(2,4,6-TRIMETHOXY-PHENYL)NITRONE, 99 1H-IMIDAZOL-1-YLOXY, 2-(1,3-BENZODIOXOL-5-YL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-, 3-OXIDE 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 3,3,4,4-TETRAMETHYL-2-TRIMETHYLAMMONIOPHENYL-2-IMIDAZOLINE-3-OXIDE-1-YLOXY CHLORIDE

c-phenyl-n-tert-butylnitrone

n-benzylidene-tert-butylamineoxide

n-tert-butyl-2-phenylnitrone

n-tert-butyl-alpha-phenyl-nitron

n-tert-butyl-c-phenylnitrone

(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide

PHENYL N-TERT-BUTYLNITRONE

PBN

N-BENZYLIDENE-TERT-BUTYLAMINE N-OXIDE

N-T-BUTYL-ALPHA-PHENYLNITRONE

N-TERT-BUTYL-ALPHA-PHENYLNITRONE

N-TERT-BUTYL-A-PHENYLNITRONE

N-tert-Butyl-α-phenylnitrone(PBN)

N-tert-Butyl-α-phenylnitrone - CAS 3376-24-7 - Calbiochem

N-Benzylidene-2-methylpropan-2-amine oxide

BENZYLIDENE(TERT-BUTYL)AMMONIUMOLATE

Phenyl N-t-butylnitrone

Butylphenylnitrone

N-benzyliden-tert-butylamine N-ether

N-tert-Butyl-α-phenylnitrone

N-T-BUTYL-A-PHENYLNITRONE

N-TERT-BUTYL-ALPHA-PHENYLNITRONE (PNB)

à-phenyl-n-tert-butylnitrone

n-tert-butyl-à-phenylnitrone

PHENYL-TERT-BUTYLNITRONE

N-tert-Butyl-ɑ-phenylnitrone, 98%

N-tert-B-butyl-alpha-phenylnitrone,98%

2-Methyl-N-(phenylmethylene)-2-propanamine N-oxide

2-Methyl-N-(phenylmethylene)-2-propanamine oxide

N-tert-Butyl-alpha-phenylnitrone,98%

N-tert-Butyl-α-phenylnitrone ,98%

N-tert-Butyl-α-phenylnitrone,N-Benzylidene-tert-butylamine N-oxide, PBN, Phenyl N-t-butylnitrone

2-methyl-n-(phenylmethylene)-2-propanaminn-oxide

2-methyl-n-(phenylmethylene)-s-propanaminen-oxide

2-methyl-n-(phenylmethylene)-s-propanaminn-oxide

2-phenyl-n-tert-butylnitrone

alpha-phenyl-n-tert-butylnitrone

Benzylidene(tert-butyl)azane oxide

benzylidene-tert-butylaminen-oxide

N-tert-Butyl-alpha-phenylnitrone, 98% 5GR

2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide

Benzylidene-tert-butylamine oxide

tert-Butyl(benzylidene)amine N-oxide

N-tert-Butyl-alpha-phenylnitrone&gt

N-TERT-BUTYL-A-PHENYLNITRONE FOR SYNTHES

(E)-tert-butyl(oxido)(phenylmethylidene)azanium

N-benzylidene-t-butylamine N-oxide

N-tert-Butyl-α-phenylnitrone, 95%+

N-tert-Butyl-α-phenylnitrone

N-benzylidene-2-methylpropane-2-amine oxide

N-tert-Butyl-α-phenylnitrone(PBN)

n-tert-butyl-n-[(e)-phenylmethylene]amine oxide

3376-24-7

C6H5CHNOCCH33

Biochemicals and Reagents

BioChemical

Cell Signaling Enzymes

Application Index