ChemicalBook > CAS DataBase List > N-TERT-BUTYL-ALPHA-PHENYLNITRONE
N-TERT-BUTYL-ALPHA-PHENYLNITRONE
- Product Name
- N-TERT-BUTYL-ALPHA-PHENYLNITRONE
- CAS No.
- 3376-24-7
- Chemical Name
- N-TERT-BUTYL-ALPHA-PHENYLNITRONE
- Synonyms
- PBN;N-tert-Butyl-α-phenylnitrone;N-tert-Butyl-α-phenylnitrone;2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide;Butylphenylnitrone;Phenyl N-t-butylnitrone;PHENYL-TERT-BUTYLNITRONE;N-T-BUTYL-A-PHENYLNITRONE;PHENYL N-TERT-BUTYLNITRONE;c-phenyl-n-tert-butylnitrone
- CBNumber
- CB8469861
- Molecular Formula
- C11H15NO
- Formula Weight
- 177.24
- MOL File
- 3376-24-7.mol
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Property
- Melting point:
- 73-74 °C(lit.)
- Boiling point:
- 283℃
- Density
- 0.990
- refractive index
- 1.5480 (estimate)
- Flash point:
- 119℃
- storage temp.
- Store at <= 20°C.
- solubility
- DMSO: soluble
- form
- powder
- pka
- 1.50±0.53(Predicted)
- color
- white
- Water Solubility
- Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
- Merck
- 14,7056
- BRN
- 2044028
- CAS DataBase Reference
- 3376-24-7(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 80126
- Product name
- N-tert-Butyl-α-phenylnitrone
- Purity
- for ESR-spectroscopy
- Packaging
- 1g
- Price
- $281
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 8.41179
- Product name
- N-tert-Butyl-α-phenylnitrone
- Purity
- for synthesis
- Packaging
- 1g
- Price
- $132
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 203995
- Product name
- N-tert-Butyl-α-phenylnitrone
- Purity
- Most commonly-used free radical trap.
- Packaging
- 500mg
- Price
- $111
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B1701
- Product name
- N-tert-Butyl-alpha-phenylnitrone
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $68
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B1701
- Product name
- N-tert-Butyl-alpha-phenylnitrone
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $218
- Updated
- 2024/03/01
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Chemical Properties,Usage,Production
Chemical Properties
white to light beige fine crystalline powder
Uses
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Uses
N-tert-Butyl-α-phenylnitrone has been used:
- as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
- as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
- to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)
Uses
Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.
Synthesis Reference(s)
Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6
General Description
Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Biochem/physiol Actions
Product does not compete with ATP.
Purification Methods
Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.]
N-TERT-BUTYL-ALPHA-PHENYLNITRONE Preparation Products And Raw materials
Raw materials
ZINC
Acetonitrile
Ethanol
Sodium sulfate
Toluene
3-Chloroperoxybenzoic acid
Benzaldehyde
Diethyl ether
Benzene
Ethyl acetate
Hydrochloric acid
Sodium bicarbonate
Potassium permanganate
Acetic acid
tert-Butylamine
PETROLEUM ETHER
Preparation Products
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23662
- Advantage
- 75
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View Lastest Price from N-TERT-BUTYL-ALPHA-PHENYLNITRONE manufacturers
Shanghai UCHEM Inc.
- Product
- N-tert-Butyl-α-phenylnitrone 3376-24-7
- Price
- US $79.00-519.00/g
- Min. Order
- 5g
- Purity
- 0.97
- Supply Ability
- 25kg
- Release date
- 2023-12-27
Career Henan Chemical Co
- Product
- 3376-24-7 3376-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04
3376-24-7, N-TERT-BUTYL-ALPHA-PHENYLNITRONERelated Search:
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