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N-TERT-BUTYL-ALPHA-PHENYLNITRONE

Product Name
N-TERT-BUTYL-ALPHA-PHENYLNITRONE
CAS No.
3376-24-7
Chemical Name
N-TERT-BUTYL-ALPHA-PHENYLNITRONE
Synonyms
PBN;N-tert-Butyl-α-phenylnitrone;N-tert-Butyl-α-phenylnitrone;2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide;Butylphenylnitrone;Phenyl N-t-butylnitrone;PHENYL-TERT-BUTYLNITRONE;N-T-BUTYL-A-PHENYLNITRONE;PHENYL N-TERT-BUTYLNITRONE;c-phenyl-n-tert-butylnitrone
CBNumber
CB8469861
Molecular Formula
C11H15NO
Formula Weight
177.24
MOL File
3376-24-7.mol
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Property

Melting point:
73-74 °C(lit.)
Boiling point:
283℃
Density 
0.990
refractive index 
1.5480 (estimate)
Flash point:
119℃
storage temp. 
Store at <= 20°C.
solubility 
DMSO: soluble
form 
powder
pka
1.50±0.53(Predicted)
color 
white
Water Solubility 
Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
Merck 
14,7056
BRN 
2044028
CAS DataBase Reference
3376-24-7(CAS DataBase Reference)
EPA Substance Registry System
2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TX1760000
F 
10
TSCA 
Yes
HS Code 
2929 90 00
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
80126
Product name
N-tert-Butyl-α-phenylnitrone
Purity
for ESR-spectroscopy
Packaging
1g
Price
$281
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41179
Product name
N-tert-Butyl-α-phenylnitrone
Purity
for synthesis
Packaging
1g
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
203995
Product name
N-tert-Butyl-α-phenylnitrone
Purity
Most commonly-used free radical trap.
Packaging
500mg
Price
$111
Updated
2024/03/01
TCI Chemical
Product number
B1701
Product name
N-tert-Butyl-alpha-phenylnitrone
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
B1701
Product name
N-tert-Butyl-alpha-phenylnitrone
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$218
Updated
2024/03/01
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Chemical Properties,Usage,Production

Chemical Properties

white to light beige fine crystalline powder

Uses

N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Uses

N-tert-Butyl-α-phenylnitrone has been used:

  • as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
  • as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
  • to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)

Uses

Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.

Synthesis Reference(s)

Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6

General Description

Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Biochem/physiol Actions

Product does not compete with ATP.

Purification Methods

Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.]

N-TERT-BUTYL-ALPHA-PHENYLNITRONE Preparation Products And Raw materials

Raw materials

ZINC Acetonitrile Ethanol Sodium sulfate Toluene 3-Chloroperoxybenzoic acid Benzaldehyde Diethyl ether Benzene Ethyl acetate Hydrochloric acid Sodium bicarbonate Potassium permanganate Acetic acid tert-Butylamine PETROLEUM ETHER

Preparation Products

2-METHYL-N-(PHENYLMETHYLENE)-2-PROPYLAMINE
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N-TERT-BUTYL-ALPHA-PHENYLNITRONE Suppliers

Americas 1 Belgium 1 Canada 1 China 114 Europe 1 Germany 4 India 4 Japan 2 Switzerland 3 United Kingdom 5 United States 22 Global 158
VladaChem GmbH
Tel
+49-7246-3082843
Email
info@vladachem.de
Country
Germany
ProdList
1859
Advantage
58
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
Merck Schuchardt OHG
Tel
--
Fax
--
Email
schuchardt-vertrieb@merck.de
Country
Germany
ProdList
5827
Advantage
74
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from N-TERT-BUTYL-ALPHA-PHENYLNITRONE manufacturers

Shanghai UCHEM Inc.
Product
N-tert-Butyl-α-phenylnitrone 3376-24-7
Price
US $79.00-519.00/g
Min. Order
5g
Purity
0.97
Supply Ability
25kg
Release date
2023-12-27
Shaanxi Dideu Medichem Co. Ltd
Product
N-TERT-BUTYL-ALPHA-PHENYLNITRONE 3376-24-7
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19
Career Henan Chemical Co
Product
3376-24-7 3376-24-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

3376-24-7, N-TERT-BUTYL-ALPHA-PHENYLNITRONERelated Search:

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine N-TERT-BUTYL-ALPHA-PHENYLNITRONE tert-Butylamine NITRON PTIO CARBOXY-PTIO 2-(4-NITROPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL N-TERT-BUTYL-D9-PHENYL-D5-NITRONE N-TERT-BUTYL-ALPHA-(2-SULFOPHENYL)NITRO& BENZYLIDENE(2-HYDROXYIMINO-1,1-DIMETHYLETHYL)AMMONIUMOLATE N-(1-CYANO-1-METHYLETHYL)-A-PHENYLNITRONE 5-AMINO-4,4-DIMETHYL-2-PHENYL-4H-IMIDAZOLE-3-OXIDE 2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, NA N-TERT-BUTYL-ALPHA-(2,4,6-TRIMETHOXY-PHENYL)NITRONE, 99 1H-IMIDAZOL-1-YLOXY, 2-(1,3-BENZODIOXOL-5-YL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-, 3-OXIDE 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 3,3,4,4-TETRAMETHYL-2-TRIMETHYLAMMONIOPHENYL-2-IMIDAZOLINE-3-OXIDE-1-YLOXY CHLORIDE

  • c-phenyl-n-tert-butylnitrone
  • n-benzylidene-tert-butylamineoxide
  • n-tert-butyl-2-phenylnitrone
  • n-tert-butyl-alpha-phenyl-nitron
  • n-tert-butyl-c-phenylnitrone
  • (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide
  • PHENYL N-TERT-BUTYLNITRONE
  • PBN
  • N-BENZYLIDENE-TERT-BUTYLAMINE N-OXIDE
  • N-T-BUTYL-ALPHA-PHENYLNITRONE
  • N-TERT-BUTYL-ALPHA-PHENYLNITRONE
  • N-TERT-BUTYL-A-PHENYLNITRONE
  • N-tert-Butyl-α-phenylnitrone(PBN)
  • N-tert-Butyl-α-phenylnitrone - CAS 3376-24-7 - Calbiochem
  • N-Benzylidene-2-methylpropan-2-amine oxide
  • BENZYLIDENE(TERT-BUTYL)AMMONIUMOLATE
  • Phenyl N-t-butylnitrone
  • Butylphenylnitrone
  • N-benzyliden-tert-butylamine N-ether
  • N-tert-Butyl-α-phenylnitrone
  • N-T-BUTYL-A-PHENYLNITRONE
  • N-TERT-BUTYL-ALPHA-PHENYLNITRONE (PNB)
  • à-phenyl-n-tert-butylnitrone
  • n-tert-butyl-à-phenylnitrone
  • PHENYL-TERT-BUTYLNITRONE
  • N-tert-Butyl-ɑ-phenylnitrone, 98%
  • N-tert-B-butyl-alpha-phenylnitrone,98%
  • 2-Methyl-N-(phenylmethylene)-2-propanamine N-oxide
  • 2-Methyl-N-(phenylmethylene)-2-propanamine oxide
  • N-tert-Butyl-alpha-phenylnitrone,98%
  • N-tert-Butyl-α-phenylnitrone ,98%
  • N-tert-Butyl-α-phenylnitrone,N-Benzylidene-tert-butylamine N-oxide, PBN, Phenyl N-t-butylnitrone
  • 2-methyl-n-(phenylmethylene)-2-propanaminn-oxide
  • 2-methyl-n-(phenylmethylene)-s-propanaminen-oxide
  • 2-methyl-n-(phenylmethylene)-s-propanaminn-oxide
  • 2-phenyl-n-tert-butylnitrone
  • alpha-phenyl-n-tert-butylnitrone
  • Benzylidene(tert-butyl)azane oxide
  • benzylidene-tert-butylaminen-oxide
  • N-tert-Butyl-alpha-phenylnitrone, 98% 5GR
  • 2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide
  • Benzylidene-tert-butylamine oxide
  • tert-Butyl(benzylidene)amine N-oxide
  • N-tert-Butyl-alpha-phenylnitrone&gt
  • N-TERT-BUTYL-A-PHENYLNITRONE FOR SYNTHES
  • (E)-tert-butyl(oxido)(phenylmethylidene)azanium
  • N-benzylidene-t-butylamine N-oxide
  • N-tert-Butyl-α-phenylnitrone, 95%+
  • N-tert-Butyl-α-phenylnitrone
  • N-benzylidene-2-methylpropane-2-amine oxide
  • N-tert-Butyl-α-phenylnitrone(PBN)
  • n-tert-butyl-n-[(e)-phenylmethylene]amine oxide
  • 3376-24-7
  • C6H5CHNOCCH33
  • Biochemicals and Reagents
  • BioChemical
  • Cell Signaling Enzymes
  • Application Index