(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

Product Name: (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
CAS No.: 76855-69-1
Chemical Name: (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
Synonyms: 4-AA;4-ACETOXYAZETIDIN-2-ONE;(3R,4R)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE;(3R,4R)-4-ACETOXY-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]AZETIDIN-2-ONE;4-AOSA;(3R<;Azetidon;4AA(AOSA);AOSA (4-AA);4-AA or 4-AOSA
CBNumber: CB0458274
Molecular Formula: C13H25NO4Si
Formula Weight: 287.43
MOL File: 76855-69-1.mol

More

Less

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Property

Melting point:: 107-109 °C(lit.)
alpha: 51 º (c=1, chloroform)
Boiling point:: 358.3±27.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: almost transparency in Methanol
form: powder to crystal
pka: 12.86±0.60(Predicted)
color: White to Almost white
optical activity: [α]20/D +51°, c = 1 in chloroform
InChIKey: GWHDKFODLYVMQG-UBHAPETDSA-N
CAS DataBase Reference: 76855-69-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,N
Risk Statements: 36-43-51/53
Safety Statements: 24-26-37-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 2
HazardClass: 9
PackingGroup: III
HS Code: 29337900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 375845
Product name: [3R(1′R,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone
Purity: 98%
Packaging: 1g
Price: $62.4
Updated: 2024/03/01

TCI Chemical

Product number: A1124
Product name: (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone
Purity: >98.0%(N)
Packaging: 5g
Price: $258
Updated: 2024/03/01

TCI Chemical

Product number: A1124
Product name: (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone
Purity: >98.0%(N)
Packaging: 25g
Price: $931
Updated: 2024/03/01

TRC

Product number: A164500
Product name: (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone
Packaging: 1g
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA16979
Product name: (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone
Packaging: 10g
Price: $92.5
Updated: 2021/12/16

More

Less

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one is an acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.

Purification Methods

Purify it by chromatography on silica gel (3 x 14cm) for 50g of ester using 20% EtOAc in n-hexane. The eluate is evaporated, and the residue is recrystallised from hexane (white fluffy crystals). [Leanza et al. Tetrahedron 39 2505 1983.]

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium hypochlorite Acetonitrile (R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl Ethanol Acetic anhydride Potassium hydroxide (R)-(+)-1,1'-Bi-2-naphthol tert-Butyldimethylsilyl chloride Triethyl orthoformate 2-Mercaptothiazoline Ruthenium(III) chloride Oxygen Triethylamine Palladium (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Benzamide Hydrochloric acid Hydrogen Dichloromethane 1,5-Cyclooctadiene Methanol tert-Butylamine

Preparation Products

More

Less

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Suppliers

Americas 1 Canada 5 China 302 Europe 2 France 1 Germany 5 India 14 Japan 6 South Korea 1 Switzerland 3 United Kingdom 15 United States 41 Global 396

Zhejiang Chenxi Technology Co., LTD

Tel: 13552015630
Email: 3558143071@qq.com
Country: China
ProdList: 499
Advantage: 58

Zhejiang Jiuzhou Pharmaceutical Co., Ltd

Tel: 13566413511
Email: le.sun@jiuzhoupharma.com
Country: China
ProdList: 31
Advantage: 58

Shandong Jincheng Pharmaceutical Group Co.,Ltd.

Tel: 0533-5439427 13964385406;
Email: henry.zhang@jinchengpharm.com
Country: China
ProdList: 34
Advantage: 58

Taizhou Huaxi Technology Co. LTD

Tel: 0576-89164227 13105618688
Fax: 0576-89164227
Email: 18323010@qq.com
Country: China
ProdList: 39
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

shilang(zhuoli group)-pharma(nanjing) co.,ltd.

Tel: 86-25-87797880,81,82 -809
Fax: 86-25-85318152
Email: shilang@shilang-pharma.com
Country: China
ProdList: 40
Advantage: 55

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

More

Less

View Lastest Price from (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one 76855-69-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-14

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: (3S,4R) -4-acetoxy-3 -[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one 76855-69-1
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-10-07

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-09-21

76855-69-1, (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-oneRelated Search:

Benzyloxyacetyl chloride N-Methyl-2-pyrrolidone Ethyl formate Ethyl propionate Ethyl acrylate Ethylparaben 2-Butanone oxime Sodium triacetoxyborohydride Ethanol Diethoxydimethylsilane Ethylbenzene Dimethyldimethoxysilane Laurocapram 2-Azetidinone Diltiazem hydrochloride 4-Acetoxystyrene Ethyl acetate T-BUTYLDIMETHYLSILANE

4-AA

(3s,4r)-4-acetoxy-3-[(r)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

(3R,4R)-(+)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE

(3R,4R)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE

(3R,4R)-4-ACETOXY-3-[(R)-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE

(3R,4R)-4-(ACETYLOXY)-3-[(1R)-1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]ETHYL]-2-AZETIDINONE

[3R(1'R,4R)]-(+)-4-ACETOXY-3-[1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE

(2R,3R)-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-4-OXOAZETIDIN-2-YLACETATE

4-AOSA

(3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

2-Azetidinone, 4-(acetyloxy)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-, (3R,4R)-

acetoxyazetidinone

(3S,4R)-4-acetoxy-3-[-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

(R R(R))-4-ACETOXY-3-(1-TBDMS-OXY)-

(3R(1'R,4R))-(+)-4-ACETOXY-3-(1-(T-BUTYL DI -METHYLSILYLOXY)ETH)-2-AZETIDINONE,98

4-ACETOXYAZETIDIN-2-ONE

[3R(1′R,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimeth

(3R,4R)-4-ACETOXY-3-[(3R)-TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE

4-ACETOXYAZETIDINE-2-ONE( 4-AA, ABA, AOSA)

(3S)-4-(4'-Fluorophenyl)-3-eth

（3S,4R）-4-Acetoxy-3-[(R)-1-(tert-butyl

4-AA (INTERMEDIATE OF CARTAPENEM)

4-ACETOXYAZETIDIN-2-ONE (4-AA , 4-ABA OR 4-AOSA)

4-ACETOXYAZETIDIN-2-ONE 4-AA(AOSA)(PENEM INTERMEDIATE )

4-acetoxyazetidin-2-one(4AA)

ACETOXYSILYLOXYAZETIDINONE

(3R,4R)-4-ACETOXY-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]AZETIDIN-2-ONE

4-Acetoxysilyloxyazetidinone

[3R(1''R)4R]-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)-ethyl]-2-azetidinon

4AA(AOSA)

(2R,3R)-3-(2-(tert-butyldimethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate

(2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate

4-AA or 4-AOSA

4-acetoxy-3-[1-(butyldimethylsilyloxy)ethyl]-2-azetidinone

[3R(1R),4R]-4-Acetoxy-3-[1-(tert-butyldimethylsiloxy)ethyl]-2-azetidinone

Carbapenem intermediate: Acetoxyazetidinone

(3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

ACETOXYSILYLOXYAZETIDINONE(AOSA)

4- acetoxy azetidone

(3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one AOSA (4-AA)

3R, 4R)-4-acetoxy-3-[(1R)-1-t-butyldimethylsilyloxyethyl]azetidin-2-one

intermediates of Meropenem

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone

AOSA (4-AA)

(3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone ,98%

(3S,4R)-4-Acetoxy-3-

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyloxy)ethyl]-2-a

3-(1-(ButyldiMethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyoxy)ethyl]azetidin-2-one

(1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldiMethylsilyloxyethyl)-2-azetidinone

(3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsiloxy)ethyl]azetidin-2-one

(3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyloxy)ethyl]azetidinone

[3R-[3α(R*),4β]]-4-(Acetyloxy)-3-[1-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethyl]-2-azetidinone

(3R,4R)-(+)-4-Acetoxy-3-[1-(R)-(tert-butyldiMethylsilyloxy)ethyl]-2-azetidinone, 98%

(2R,3S)-3-[(1R)-1-[(tert-butyldiMethylsilyl)oxy]ethyl]-4-oxoazetidin-2-yl acetate

4-AA ((2R,3R)-3-((R)-1-(tert-Butyldimethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate)

(3S 4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethy