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TERBUTALINE SULFATE

Product Name
TERBUTALINE SULFATE
CAS No.
23031-32-5
Chemical Name
TERBUTALINE SULFATE
Synonyms
TERBUL;Convon;bricanyl;MONOVENT;BRETHINE;Brithine;Butalire;fate saL;TerbutaL;TERBASMIN
CBNumber
CB4164487
Molecular Formula
C24H40N2O10S
Formula Weight
548.65
MOL File
23031-32-5.mol
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TERBUTALINE SULFATE Property

Melting point:
246-248°C
Density 
1.1840 (rough estimate)
refractive index 
1.6900 (estimate)
storage temp. 
2-8°C
solubility 
H2O: soluble100mg/mL, clear to slightly hazy, colorless to yellow
form 
neat
pka
pKa1 8.8, pKa2 10.1, pKa3 11.2(at 25℃)
InChIKey
KFVSLSTULZVNPG-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43-63
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DN9000000
HS Code 
2922504500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T2528
Product name
Terbutaline hemisulfate salt
Packaging
1g
Price
$67.6
Updated
2021/12/16
Sigma-Aldrich
Product number
T0050000
Product name
Terbutaline sulfate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/12/16
Sigma-Aldrich
Product number
1643500
Product name
Terbutaline sulfate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$297
Updated
2021/12/16
Sigma-Aldrich
Product number
T2528
Product name
Terbutaline hemisulfate salt
Packaging
5g
Price
$271
Updated
2021/03/22
Sigma-Aldrich
Product number
T0050000
Product name
Terbutaline sulfate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
t0050000
Price
$190
Updated
2020/08/18
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TERBUTALINE SULFATE Chemical Properties,Usage,Production

Description

Terbutaline is the N-t-butyl analogue of metaproterenol and, as such, would be expected to have a more potent β2-selectivity. When compared to metaproterenol, terbutaline has a threefold greater potency at the β2-receptor. Like metaproterenol, it is resistant to COMT and slowly metabolized by MAO, therefore having good oral bioavailability with similar onset and duration. Terbutaline is available as tablets and solutions for injection and inhalation. Adverse effects are similar to other direct-acting β2-selective agonists, however, with a greater incidence of palp

Description

Terbutaline (hemisulfate) (Item No. 21292) is an analytical reference standard categorized as a β2-adrenergic receptor agonist. Terbutaline has been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 29337).

Chemical Properties

White or almost white, crystalline powder.

Originator

Bricanyl,Pharma-Stern,W. Germany,1971

Uses

betaadrenergic agonist, bronchodilator

Uses

Anti Asthmatic

Uses

A B-Adrenergic receptor agonist. A Bronchodilator

Manufacturing Process

To a solution of 32 g of benzyl-t-butylamine in 300 ml of absolute ethanol at reflux temperature was added 32 g of 3,5-dibenzyloxy-?-bromoacetophenone in 10 ml of dry benzene. The mixture was refluxed for 20 hours and then evaporated. When absolute ether was added to the residue, benzyl-tbutylamine hydrobromide was precipitated. The precipitated compound was filtered off and to the filtrate was added an excess of 2 N sulfuric acid. This caused precipitation of the hydrogen sulfate of 3,5-dibenzyloxy-?-(benzyl-tbutylamino)- acetophenone which was recrystallized from acetone/ether. If the product is crystallized from different organic solvents, the melting point will vary with the type and amount of solvent of crystallization, but the product can be used directly for hydrogenation.
15 g of 3,5-dibenzyloxy-?-(benzyl-t-butylamino)-acetophenone hydrogen sulfate in 200 ml of glacial acetic acid were hydrogenated in a Parr pressure reaction apparatus in the presence of 1.5 g of 10% palladium charcoal at 50°C and 5 atmospheres pressure. The reaction time was 5 hours. The catalyst was filtered off, the filtrate was evaporated to dryness and the hydrogen sulfate of 1-(3',5'-dihydroxyphenyl)-2-(t-butylamino)-ethanol was received. This compound is hygroscopic, but it can be transformed into a nonhygroscopic sulfate in the following manner.
The hydrogen sulfate was dissolved in water and the pH of the solution was adjusted to 5.6 (pH-meter) with 0.1 N sodium hydroxide solution. The water solution was evaporated to dryness and the residue dried with absolute ethanol/benzene and once more evaporated to dryness. The remaining crystal mixture was extracted in a Soxhlet extraction apparatus with absolute methanol. From the methanol phase the sulfate of 1-(3',5'-dihydroxyphenyl)- 2-(t-butylamino)-ethanol crystallized. Melting point 246°C to 248°C.

brand name

Terbutaline is INN and BAN.

Therapeutic Function

Bronchodilator

Veterinary Drugs and Treatments

Terbutaline is used as a bronchodilating agent in the adjunctive treatment of cardiopulmonary diseases (including tracheobronchitis, collapsing trachea, pulmonary edema, and allergic bronchitis) in small animals. It may be of some benefit in treating bradyarrhythmias in dogs and cats.
Terbutaline has been used occasionally in horses for its bronchodilating effects, but adverse effects, short duration of activity after IV administration and poor oral absorption have limited its use. It has been shown to be useful as a diagnostic agent to diagnose anhidrosis in horses after intradermal injection.
Oral and intravenous terbutaline has been used successfully in humans for the inhibition of premature labor clinical signs.

TERBUTALINE SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERBUTALINE SULFATE Suppliers

Beijing Honghuixin Medical Technology Co.,Ltd.
Tel
0101-80456172-
Email
haiquan.guan@honghui-meditech.com
Country
China
ProdList
216
Advantage
58
Shengyang Runze (Beijing) Technology Co.,
Tel
Email
lyt001@syrz01.com
Country
China
ProdList
97
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43430
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
BEST-REAGENT
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
Country
China
ProdList
11718
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Changzhou Wanyao Biotechnology Co., Ltd.
Tel
0519-89185693-
Fax
0519-89185693
Email
2410037592@qq.com;
Country
China
ProdList
192
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9686
Advantage
60
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View Lastest Price from TERBUTALINE SULFATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Terbutaline Sulfate 23031-32-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%-101%; BP
Supply Ability
100KGS
Release date
2021-06-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
TERBUTALINE SULFATE 23031-32-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Dideu Industries Group Limited
Product
TERBUTALINE SULFATE USP/EP/BP 23031-32-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-05-28

23031-32-5, TERBUTALINE SULFATERelated Search:


  • 1-(3,5-dihydroxyphenyl)-2-tert-butylaminoethanolsulphate
  • 3-benzenediol,5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-sulfate(2
  • alpha-((tert-butylamino)methyl)-3,5-dihydroxybenzylalcoholsulfate(2:1)(sa
  • alpha-((tert-butylamino)methyl)-3,5-dihydroxy-benzylalcohosulfate(2:1)
  • bricanyl
  • Bricanyl[R]
  • 2-tert-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, Brethaire, Brethine, Butaliret, Monovent, Terbasmin, Terbul
  • TERBASMIN
  • TERBUTALINE HEMISULFATE
  • TERBUTALINE HEMISULFATE SALT
  • TERBUTALINE SULFATE
  • TERBUTALINE SULPHATE
  • TERBUTALIN SULFATE
  • TERBUL
  • MONOVENT
  • BRETHAIRE
  • BRETHINE
  • BUTALIRET
  • TERBUTALINESULFATE,USP
  • 1,3-Benzenediol, 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-, sulfate (2:1) (salt) (9CI)
  • 2-(tert-Butylamino)-1-(3,5-dihydroxyphenyl)ethanol sulfate (2:1)
  • Benzyl alcohol, a-[(tert-butylamino)methyl]-3,5-dihydroxy-, sulfate (2:1) (salt) (8CI)
  • Brithine
  • dl-Terbutaline sulfate
  • 2-T-BUTYLAMINO-1-(3,5-DIHYDROXYPHENYL)ETHANOL
  • 2-T-BUTYLAMINO-1-[3,5-DIHYDROXYPHENYL]ETHANOL HEMISULFATE SALT
  • 1,3-Benzenediol, 5-2-(1,1-dimethylethyl)amino-1-hydroxyethyl-, sulfate (2:1) (salt)
  • 2-tert-Butylamino-1-(3,5-dihydroxyphenyl)ethanol hemisulfate
  • Butalire
  • 3,5-Dihydroxy-α-[[(1,1-dimethylethyl)amino]methyl]benzyl alcohol·0.5sulfuric acid
  • Convon
  • Terbutaline hemisulphate
  • Terbutaline heMisulfate sa
  • 1,3-Benzenediol, 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-, sulfate (2:1)
  • Terbutaline solution
  • 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol sulfate (2:1) (salt)
  • Terbutaline Sulfate (125 mg)
  • Terbutaline hemisulfate salt Solution, 100ppm
  • TERBUTALINE SULFATE 98%
  • Terbutaline sulfate, 98%, a β2-adrenergic receptor agonist
  • Terbutaline O-sulfate
  • Terbutaline sulfate CRS
  • fate saL
  • ine hemisuL
  • TerbutaL
  • 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol,sulfuricaci
  • TERBUTALINE SULFATE USP/EP/BP
  • bis(5-[2-(tert-butylamino)-1-hydroxyethyl]benzene -1,3-diol)
  • 23031-32-5
  • 23013-32-5
  • C24H38N2O6H2SO4
  • C12H19NO312H2SO4
  • 2C12H19NO3H2O4S
  • 2C12H19NO3H2SO4
  • C24H38N2O6H2O4S
  • C24H40N2SO10
  • C24H40N2O10S
  • 2743