H-89 DIHYDROCHLORIDE HYDRATE

Product Name: H-89 DIHYDROCHLORIDE HYDRATE
CAS No.: 130964-39-5
Chemical Name: H-89 DIHYDROCHLORIDE HYDRATE
Synonyms: H 89 2HCl;5-Isoquinolinesulfonamide;H-89 DIHYDROCHLORIDE HYDRATE;H-89 hydrate dihydrochloride;H-89 DIHYDROCHLORIDE HYDRATE USP/EP/BP;Protein kinase inhibitor H-89 dihydrochloride;H-89 Dihydrochloride Hydrate,N-[2-(P-Bromocinnamylamino)Et;H-89 dihydrochloride(Protein kinase inhibitor H-89 dihydrochloride);PROTEIN KINASE INHIBITOR H-89 DIHYDROCHLORIDE; H89 DIHYDROCHLORIDE;H 89;(E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride
CBNumber: CB9972711
Molecular Formula: C20H20BrN3O2S.2ClH.H2O
Formula Weight: 537.304
MOL File: 130964-39-5.mol

More

Less

H-89 DIHYDROCHLORIDE HYDRATE Property

Melting point:: 195-200°C
storage temp.: Inert atmosphere,2-8°C
solubility: H2O: ≥10mg/mL
form: powder
color: off-white

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2935909099

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B1427
Product name: H-89 dihydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 10010556
Product name: H-89 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 10010556
Product name: H-89 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 10010556
Product name: H-89 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 10010556
Product name: H-89 (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $356
Updated: 2024/03/01

More

Less

H-89 DIHYDROCHLORIDE HYDRATE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Uses

Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM.

Definition

ChEBI: N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride is a hydrochloride salt prepared from N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide and two equivalents of hydrogen chloride. It has a role as an EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor. It contains a N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide(2+).

Biological Activity

h 89 2hcl is a potent pka inhibitor. in a cell-free assay, the ki of h 89 is 48 nm, 10-fold selective for pka than pkg and 500-fold greater selectivity than pkc, mlck, calmodulin kinase ii and casein kinase i/ii [1].[1]. chijiwa t, mishima a, hagiwara m, et al. inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic amp-dependent protein kinase, n-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (h-89), of pc12d pheochromocytoma cells[j]. journal of biological chemistry, 1990, 265(9): 5267-5272.[2]. lochner a, moolman j a. the many faces of h89: a review[j]. cardiovascular drug reviews, 2006, 24(3‐4): 261-274.[3]. lee t h, linstedt a d. potential role for protein kinases in regulation of bidirectional endoplasmic reticulum-to-golgi transport revealed by protein kinase inhibitor h89[j]. molecular biology of the cell, 2000, 11(8): 2577-2590.

Biochem/physiol Actions

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K+) current in rat myocytes. It mediates Na+ transport by interacting with α subunits of epithelial Na+ channel (ENaC).

in vitro

in pc12d cells, pretreatment with h-89 dose-dependently inhibited the forskolin-induced protein phosphorylation, with no influence in intracellular cyclic amp levels. in pc12d cells, h-89 significantly inhibited the forskolin-induced neurite outgrowth. in pc12d cells, pretreatment with h-89 (30 μm) strikingly inhibited camp-dependent histone iib phosphorylation activity in cell lysates while showed no effects on other protein phosphorylation activity such as cgmp-dependent histone iib phosphorylation activity [1]. h 89 was a potent and selective pka inhibitor with ki of 48 nm in a cell-free assay [2]. h89 also inhibited s6k1, msk1, pka, rockii, pkbα and mapkap-k1b kinases with ic50 of 80, 120, 135, 270, 2600 and 2800 nm, respectively [2]. in the hypotonic medium, 50 μm h89, a concentration commonly used to inhibit pka, prevented the redistribution response. in normal medium, h89 (50 μm) induced the redistribution of ergic 53 to the er by 20 min [3].

storage

-20°C

H-89 DIHYDROCHLORIDE HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

H-89 DIHYDROCHLORIDE HYDRATE Suppliers

Canada 1 China 105 India 2 Switzerland 1 United Kingdom 1 United States 12 Global 122

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8014
Advantage: 62

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1637
Advantage: 59

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

130964-39-5, H-89 DIHYDROCHLORIDE HYDRATERelated Search:

GO 6983 U0126-EtOH 1,9-Pyrazoloanthrone GF109203X LY 294002 HYDROCHLORIDE Forskolin N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

H-89 DIHYDROCHLORIDE HYDRATE

H-89 hydrate dihydrochloride

H-89 dihydrochloride hydrate,N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride

5-IsoquinolinesulfonaMide, N-[2-[[3-(4-broMophenyl)-2-propenyl]aMino]ethyl]-, dihydrochloride

N-[2-[[3-(4-BroMophenyl)-2-propen-1-yl]aMino]ethyl]-5-isoquinolinesulfonaMide Hydrochloride

H 89 2HCl

Protein kinase inhibitor H-89 dihydrochloride

(E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride

(E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride

H-89 Dihydrochloride Hydrate,N-[2-(P-Bromocinnamylamino)Et

N-[2-[[3-(4-Bromophenyl)-2-Propen-1-Yl]Amino]Ethyl]-5-Isoquinolinesulfonamide Hydrochloride (1:2)

PROTEIN KINASE INHIBITOR H-89 DIHYDROCHLORIDE; H89 DIHYDROCHLORIDE;H 89

H-89 dihydrochloride(Protein kinase inhibitor H-89 dihydrochloride)

PROTEIN KINASE INHIBITOR H-89 DIHYDROCHLORIDE;H89 DIHYDROCHLORIDE;H 89 DIHYDROCHLORIDE;H 89;H89

5-Isoquinolinesulfonamide

H-89 DIHYDROCHLORIDE HYDRATE USP/EP/BP

Protein kinase inhibitor H-89 dihydrochloride|||H 89 2HCl|||5-Isoquinolinesulfonamide

130964-39-5

Inhibitors

Akt

mTOR

PI3K

PI3K/Akt/mTOR

Protein Kinase Inhibitors and Activators