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Forskolin

Product Name
Forskolin
CAS No.
66575-29-9
Chemical Name
Forskolin
Synonyms
HL 362;CS-736;Forsklin;COLEONOL;Boforsin;ForsLean;FORSKOLIN;COLFORSIN;NSC 35708;Forskolii
CBNumber
CB0167677
Molecular Formula
C22H34O7
Formula Weight
410.5
MOL File
66575-29-9.mol
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Forskolin Property

Melting point:
282-232 °C
Boiling point:
520℃
alpha 
D25 -26.19° (c = 1.68 in CHCl3)
Density 
1.23
refractive index 
1.5300 (estimate)
Flash point:
172℃
storage temp. 
room temp
solubility 
DMSO: 5 mg/mL stable at least 6 months at room temperature
form 
powder
pka
11.00±0.70(Predicted)
color 
off-white
Water Solubility 
Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.
λmax
305nm(lit.)
Merck 
14,2476
BRN 
1692716
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey
OHCQJHSOBUTRHG-KGGHGJDLSA-N
LogP
2.406 (est)
CAS DataBase Reference
66575-29-9
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Safety

Hazard Codes 
Xn
Risk Statements 
21
Safety Statements 
22-36/37
WGK Germany 
3
RTECS 
QL6150000
10-21
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H312Harmful in contact with skin

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
344270
Product name
Forskolin
Packaging
10mg
Price
$225
Updated
2024/03/01
Sigma-Aldrich
Product number
1283244
Product name
Forskolin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
40mg
Price
$741
Updated
2024/03/01
TCI Chemical
Product number
F0855
Product name
Forskolin
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$144
Updated
2024/03/01
TCI Chemical
Product number
F0855
Product name
Forskolin
Purity
>95.0%(HPLC)
Packaging
50mg
Price
$486
Updated
2024/03/01
Alfa Aesar
Product number
J63292
Product name
Forskolin, 98+%
Packaging
10mg
Price
$196
Updated
2024/03/01
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Forskolin Chemical Properties,Usage,Production

Description

Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5

Chemical Properties

Colorless Crystalline Solid

Uses

Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.

Uses

glucocorticoid, antiinflammatory

Uses

adenylate cyclase activator, antiglaucoma, hypotensive, vasodilator

Uses

Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.[Cayman Chemical]

Uses

An adenylate cyclase activator and MAP kinase inhibitor

Uses

In purification of adenylate cyclase.

Definition

ChEBI: Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. It has a role as a plant metabolite, an anti-HIV agent, a protein kinase A agonist, an adenylate cyclase agonist, an antihypertensive agent and a platelet aggregation inhibitor. It is a labdane diterpenoid, an acetate ester, an organic heterotricyclic compound, a triol, a cyclic ketone and a tertiary alpha-hydroxy ketone.

General Description

Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).

Biological Activity

Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

Purification Methods

It is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]

References

1) Awad et al (1983) Interactions of forskolin and adenylate cyclase; J. Biol. Chem., 258 2960 2) Bhat et al (1983) The antihypertensive and positive inotropic diterpene forskolin: effects of structural modifications on its activity; J. Med. Chem., 26 486 3) de Souza et al. (1983) Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties; Med. Res. Rev. 3 201 4) Aylwin & White (1992) Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors; Mol. Pharmacol. 41 908 5) Insel & Ostrom (2003) Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling; Cell Mol. Neurobiol., 23 305

Forskolin Preparation Products And Raw materials

Raw materials

Preparation Products

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Forskolin Suppliers

Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Tel
025-84430028 13815430202
Email
sale02@cqherb.com
Country
China
ProdList
281
Advantage
59
Nanjing Yuanzhi Biotechnology Co. Ltd.
Tel
15805159960
Email
1211550495@qq.com
Country
China
ProdList
1795
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6813
Advantage
58
Xi'an Kono chem co., Ltd.,
Tel
029-029-86107037-8012-8012 18729555803
Fax
15691813064
Email
sales9@konochemical.com
Country
China
ProdList
293
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from Forskolin manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
FORSKOLIN 66575-29-9
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-07
Hebei Longbang Technology Co., Ltd
Product
Forskolin 66575-29-9
Price
US $6.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-06-05
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Forskolin 66575-29-9
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥98%
Supply Ability
20tons
Release date
2024-01-03

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