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L-858051

Product Name
L-858051
CAS No.
115116-37-5
Chemical Name
L-858051
Synonyms
L-858051;L-858,051 (hydrochloride);L858,051 (hydrochloride),L 858,051 (hydrochloride);7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL;7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride;Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride;Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride;FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE;8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
CBNumber
CB2703053
Molecular Formula
C29H50Cl2N2O7
Formula Weight
609.62
MOL File
Mol file
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L-858051 Property

storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
form 
A crystalline solid
color 
white
Water Solubility 
water: 12mg/mL
methanol: soluble
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21206
Product name
L-858,051 (hydrochloride)
Purity
≥95%
Packaging
500μg
Price
$36
Updated
2023/06/20
Cayman Chemical
Product number
21206
Product name
L-858,051 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$66
Updated
2023/06/20
Cayman Chemical
Product number
21206
Product name
L-858,051 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$277
Updated
2023/06/20
AK Scientific
Product number
1919CV
Product name
[(3R,4Ar,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]4-(4-methylpiperazin-1-yl)butanoate;dihydrochloride
Packaging
1mg
Price
$174
Updated
2021/12/16
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L-858051 Chemical Properties,Usage,Production

Description

L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5

References

1. Laurenza, A., Khandelwal, Y., De Souza, N.J., et al. Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol. Pharmacol. 32(1),133-139(1987).
2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action Mol. Pharmacol. 33(4),449-453(1988).
3. Funaki, C., Hodges, R.R., and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland Am. J. Physiol. Cell Physiol. 293(5),C1551-C1560(2007).
4. Luo, S.-F., Chiu, C.-T., Tsao, H.-L., et al. Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells Cell. Signal. 9(2),159-167(1997).
5. Haj Slimane, Z., Bedioune, I., Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes Cardiovasc. Res. 102(1),97-106(2014).

L-858051 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-858051 Suppliers

CHINA 21 Japan 1 United Kingdom 1 United States 4 Global 27
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Enzo Biochem Inc
Tel
Enzo Biochem Inc. 13797054060
Email
Enzoname@qq.com
Country
China
ProdList
6174
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
Advantage
58
Guangzhou Qingyan Biotechnology Co., Ltd.
Tel
19802084049
Country
CHINA
ProdList
171
Advantage
58
Foshan Minghua Biotechnology Co., Ltd.
Tel
18312287787
Country
CHINA
ProdList
196
Advantage
58

115116-37-5, L-858051Related Search:

Forskolin

  • 8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
  • 7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL
  • L-858051
  • FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE
  • L-858,051 (hydrochloride)
  • L858,051 (hydrochloride),L 858,051 (hydrochloride)
  • Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride
  • Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride
  • 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-Forskolin Dihydrochloride
  • 115116-37-5