L-858051
- Product Name
- L-858051
- CAS No.
- 115116-37-5
- Chemical Name
- L-858051
- Synonyms
- L-858051;L-858,051 (hydrochloride);L858,051 (hydrochloride),L 858,051 (hydrochloride);7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL;FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE;8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
- CBNumber
- CB2703053
- Molecular Formula
- C29H50Cl2N2O7
- Formula Weight
- 609.62
- MOL File
- Mol file
L-858051 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 21206
- Product name
- L-858,051 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $36
- Updated
- 2023/06/20
- Product number
- 21206
- Product name
- L-858,051 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $66
- Updated
- 2023/06/20
- Product number
- 21206
- Product name
- L-858,051 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $277
- Updated
- 2023/06/20
- Product number
- 1919CV
- Product name
- [(3R,4Ar,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]4-(4-methylpiperazin-1-yl)butanoate;dihydrochloride
- Packaging
- 1mg
- Price
- $174
- Updated
- 2021/12/16
L-858051 Chemical Properties,Usage,Production
Description
L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5
References
1. Laurenza, A., Khandelwal, Y., De Souza, N.J., et al. Stimulation of adenylate cyclase by water-
2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action Mol. Pharmacol. 33(4),449-453(1988).
3. Funaki, C., Hodges, R.R., and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-
4. Luo, S.-F., Chiu, C.-T., Tsao, H.-L., et al. Effect of forskolin on bradykinin-
5. Haj Slimane, Z., Bedioune, I., Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes Cardiovasc. Res. 102(1),97-106(2014).
L-858051 Preparation Products And Raw materials
Raw materials
Preparation Products
L-858051 Suppliers
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24649
- Advantage
- 58
- Tel
- +8613564774135
- zijue.cai@tsbiochem.com
- Country
- United States
- ProdList
- 19863
- Advantage
- 58