Forskolin

Product Name: Forskolin
CAS No.: 66575-29-9
Chemical Name: Forskolin
Synonyms: HL 362;CS-736;Forsklin;COLEONOL;Boforsin;ForsLean;FORSKOLIN;COLFORSIN;NSC 35708;Forskolii
CBNumber: CB0167677
Molecular Formula: C22H34O7
Formula Weight: 410.5
MOL File: 66575-29-9.mol

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Forskolin Property

Melting point:: 282-232 °C
Boiling point:: 520℃
alpha: D25 -26.19° (c = 1.68 in CHCl3)
Density: 1.23
refractive index: 1.5300 (estimate)
Flash point:: 172℃
storage temp.: room temp
solubility: DMSO: 5 mg/mL stable at least 6 months at room temperature
form: powder
pka: 11.00±0.70(Predicted)
color: off-white
Water Solubility: Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.
λmax: 305nm(lit.)
Merck: 14,2476
BRN: 1692716
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey: OHCQJHSOBUTRHG-KGGHGJDLSA-N
LogP: 2.406 (est)
CAS DataBase Reference: 66575-29-9

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Safety

Hazard Codes: Xn
Risk Statements: 21
Safety Statements: 22-36/37
WGK Germany: 3
RTECS: QL6150000
F: 10-21
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H312Harmful in contact with skin

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 344270
Product name: Forskolin
Packaging: 10mg
Price: $225
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1283244
Product name: Forskolin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 40mg
Price: $741
Updated: 2024/03/01

TCI Chemical

Product number: F0855
Product name: Forskolin
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $144
Updated: 2024/03/01

TCI Chemical

Product number: F0855
Product name: Forskolin
Purity: >95.0%(HPLC)
Packaging: 50mg
Price: $486
Updated: 2024/03/01

Alfa Aesar

Product number: J63292
Product name: Forskolin, 98+%
Packaging: 10mg
Price: $196
Updated: 2024/03/01

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Forskolin Chemical Properties,Usage,Production

Description

Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5

Chemical Properties

Colorless Crystalline Solid

Uses

Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.

Uses

glucocorticoid, antiinflammatory

Uses

adenylate cyclase activator, antiglaucoma, hypotensive, vasodilator

Uses

Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.[Cayman Chemical]

Uses

An adenylate cyclase activator and MAP kinase inhibitor

Uses

In purification of adenylate cyclase.

Definition

ChEBI: Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. It has a role as a plant metabolite, an anti-HIV agent, a protein kinase A agonist, an adenylate cyclase agonist, an antihypertensive agent and a platelet aggregation inhibitor. It is a labdane diterpenoid, an acetate ester, an organic heterotricyclic compound, a triol, a cyclic ketone and a tertiary alpha-hydroxy ketone.

General Description

Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).

Biological Activity

Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

Purification Methods

It is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]

References

1) Awad et al (1983) Interactions of forskolin and adenylate cyclase; J. Biol. Chem., 258 2960 2) Bhat et al (1983) The antihypertensive and positive inotropic diterpene forskolin: effects of structural modifications on its activity; J. Med. Chem., 26 486 3) de Souza et al. (1983) Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties; Med. Res. Rev. 3 201 4) Aylwin & White (1992) Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors; Mol. Pharmacol. 41 908 5) Insel & Ostrom (2003) Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling; Cell Mol. Neurobiol., 23 305

Forskolin Preparation Products And Raw materials

Raw materials

Preparation Products

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Forskolin Suppliers

Americas 1 Australia 2 Belgium 2 Canada 3 China 271 Czech Republic 1 Europe 3 France 1 Germany 11 India 49 Japan 5 Poland 1 South Korea 1 Switzerland 4 United Kingdom 20 United States 65 Global 440

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View Lastest Price from Forskolin manufacturers

HebeiShuoshengImportandExportco.,Ltd

Product: FORSKOLIN 66575-29-9
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-07

Hebei Longbang Technology Co., Ltd

Product: Forskolin 66575-29-9
Price: US $6.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20TONS
Release date: 2024-06-05

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Forskolin 66575-29-9
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-03

66575-29-9, ForskolinRelated Search:

Chaetocin Hypericin PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- FORSKOLIN, 7-O-HEMISUCCINYL-7-DEACETYL,FORSKOLIN, 7-DEACETYL-7-O-HEMISUCCINYL- Forskolin FORSKOLIN, 1,9-DIDEOXY,FORSKOLIN, 1,9-DIDEOXY-, COLEUS FORSKOHLII FORSKOLIN DIHYDRO CUMINYL ALCOHOL SUCCINYLCHOLINE CHLORIDE DIHYDRATE FORSKOLIN, 6-ACETYL-7-DEACETYL- FORSKOLIN, 7-DEACETYL- N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE 7-DEACETYL-1,9-DIDEOXY-FORSKOLIN FORSKOLIN RESIN BODIPY(R) FL FORSKOLIN FORSKOLIN, 7BETA-DEACETYL-7BETA-(GAMMA-N-METHYLPIPERAZINO)-BUTYRYL DIHYDROCHLORIDE FORSKOLIN, 7BETA-DEACETYL-7BETA-[GAMMA-(MORPHOLINO) BUTYRYL]-, HYDROCHLORIDE

7BETA-ACETOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE

7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE

7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-ENE-11-ONE

[3R-(3A,4AB,5B,6B,6AA,10A,10AB,10BA)]-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-6,10,10B-TRIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1H-NAPHTHO[2,1-B]PYRAN-1-ONE

10a-beta,10b-alpha))-10-alph

1-b)pyran-1-one,dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-1h-naphtho(

pentamethyl-6,10,10b-trihydroxy-,(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,

FORSKOLIN FROM COLEUS FORSKOHLII

FORSKOLIN, MOLECULAR BIOLOGY REAGENT

FORSKOLIN 98+%

FORSKOLIN, 99+%

Forsklin

1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-

Forskolin ForsLean Colforsin HL 362 NSC 357088 NSC 375489

BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE

FORSKOHLIN

FORSKOLIN

FORSKOLIN, COLEUS FORSKOHLII

COLEONOL

COLFORSIN

(3R,4AR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldod

Boforsin

Coleus forskohlii(Willd.)Briq.

Forskolin, 98%, from Coleus forskohlii

Forskolin (plant extract)

Forskolin ( Coleus Forskohlii extract)

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one

ForsLean

HL 362

L 75-1362B

NSC 35708

7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

Forskolin, Colforsin, Coleonol

FORMYL-O-BENZYL-L-SERINE

Coleonol, Colforsin

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-β]pyran-1-one

NSC 357088

7SS-ACETOXY-8,13-EPOXY-1ALPHA,6SS,9ALPHA-TRIHYDROXYLABD-14-EN-11-ONE

Coleonol, Colforsin, 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

Colforsin, Boforsin

[3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10betaalpha)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

(3R,6aα)-5β-Acetoxy-3α-ethenyldodecahydro-6β,10α,10bα-trihydroxy-3,4aβ,7,7,10aβ-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

7-Acetoxy-8,13-epoxy-1alpha,6,9alpha-trihydroxylabd-14-en-11-one

7β-Acetoxy-8,23-epoxy-1 α

ForskolinColforsin

[3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

NSC 375489

Forskolin (40 mg) (7Beta-acetoxy-8,13-epoxy-1alpha,6Beta,9alpha-trihydroxy-labd-14-en-11-one)

Forskolii

Forskolin - Coleonol

CS-736

Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem

Forskolin &gt

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate

Forskolin, ≥98% (HPLC), powder

2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOL

Forskolin supplier in China

Coleus Forskolin