Hypericum perforatum extracts Indications Uses
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Hypericin

Hypericum perforatum extracts Indications Uses
Product Name
Hypericin
CAS No.
548-04-9
Chemical Name
Hypericin
Synonyms
VIMRxyn;CYCLOSAN;HYPERICIN;Hypericine;Hypericins;MYCOPOPHYRIN;CYCLO-WERROL;HYPERICIN(P);MYCOPORPHYRIN;HYPERICUM RED
CBNumber
CB2696784
Molecular Formula
C30H16O8
Formula Weight
504.44
MOL File
548-04-9.mol
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Hypericin Property

Melting point:
299-301°C
Boiling point:
1020.3±65.0 °C(Predicted)
Density 
1.915±0.06 g/cm3(Predicted)
RTECS 
SF8472000
storage temp. 
-20°C
solubility 
1 M NaOH: 10 mg/mL
form 
powder
pka
6.91±0.20(Predicted)
color 
black
Water Solubility 
Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water.
Sensitive 
Light Sensitive
Merck 
14,4863
BRN 
1917913
InChIKey
BTXNYTINYBABQR-UHFFFAOYSA-N
CAS DataBase Reference
548-04-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-40-43
Safety Statements 
22-36-36/37
RIDADR 
2811
WGK Germany 
3
8
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
400076-M
Product name
Hypericin - CAS 548-04-9 - Calbiochem
Purity
Polycyclic dione that has anti-retroviral activity.
Packaging
1 mg
Price
$146.15
Updated
2021/03/22
Sigma-Aldrich
Product number
400076-M
Product name
Hypericin
Purity
Polycyclic dione that has anti-retroviral activity.
Packaging
1mg-m
Price
$158
Updated
2020/08/18
Sigma-Aldrich
Product number
PHL89226
Product name
Hypericin
Purity
phyproof? Reference Substance
Packaging
10 mg
Price
$523
Updated
2021/03/22
Sigma-Aldrich
Product number
00190585
Product name
Hypericin
Purity
primary pharmaceutical reference standard
Packaging
10mg
Price
$713
Updated
2021/03/22
Alfa Aesar
Product number
H26425
Product name
Hypericin, 98%
Packaging
100mg
Price
$1480
Updated
2020/06/24
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Hypericin Chemical Properties,Usage,Production

Hypericum perforatum extracts

Hypericin is an extract of Hypericum perforatum L.In 1957. It is first isolated from the Garcinia species Hypericum perforatum by human beings. Hypericin belongs to the bianthrone compounds, and it is the most biologically active substances. Hypericin is a yellowish brown to brown mobile powder, with slightly bitter taste. It is soluble in water, and can emit a special fragrance. It can inhibit the central nervous and has a sedative effect. Adding it to health care products can enhance immunity. It is also used as antidepressant drugs in Europe (especially in Germany). Hypericin also has a strong anti-viral effect, which can directly act on swine fever, foot and mouth disease and other viruses. In addition, it also has a good effect on killing highly pathogenic avian influenza virus.
Hypericum perforatum is one of the world's best-selling herbs in recent years, mainly containing hyperoside, quercetin, chlorogenic acid, caffeic acid, imanin, hypericin and other ingredients.
Hypericin is a few thousandths of the whole Hypericum perforatum. There are certain requirements for its extraction and testing. Methanol extraction method is common used in the past. Due to the toxicity of methanol, now the method is   converted to use ethanol to obtain the active ingredient.

Indications

Hypericin is an anti-virus and pure Chinese medicine preparations. It is the first choice for the prevention and treatment of avian influenza drugs.
1, avian influenza, atypical Newcastle disease, infectious bronchitis, avian infectious laryngotracheitis , bursa of Fabricius, duck plague, duck viral hepatitis, egg drop syndrome and other viral diseases.
2, poultry fever caused by high fever, dyspnea, cough, head and face swelling, crown hair purple, lack of energy, decreased feed intake, egg drop, producing more abnormal eggs.
3, for classical swine fever, blue ear disease, parvovirus, viral enteritis, infectious gastroenteritis and immune dysfunction.
4, Hypericin has a strong anti-viral effect both in vivo and in vitro. It has a strong inhibitory effect on the early replication of HIV. Hypericin can lead to cancer cell programmed death, with anti-cancer effect. It has a enhanced immune function  for activating mononuclear phagocytic cells. In addition, it has a strong role in killing the highly pathogenic H5N1 and H9N2 subtype of avian influenza virus.

Uses

(1) Antidepressant, increase immunity.
(2) For the treatment of antidepressants, increase immunity.

Chemical Properties

Powder

Biological Activity

Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.

Purification Methods

Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.]

Hypericin Preparation Products And Raw materials

Raw materials

Preparation Products

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Hypericin Suppliers

Chengdu Alfa Biotechnology Co.,Ltd.
Tel
028-85142057 / 18030712385
Fax
028-85142057 QQ:3591697873
Email
sales@alfabiotech.com
Country
China
ProdList
1925
Advantage
58
Guangzhou Shunyi Pharmaceutical Chemical Co., Ltd.
Fax
QQ:1506687511
Email
jasontim@shuntongchem.cn;jasontim@shuntongchem.cn
Country
China
ProdList
40
Advantage
58
Shanghai Jiaoze Industrial Co., LTD
Tel
021-37318802-
Fax
021-37318802
Email
liangpanpan@sh-jiaoze.com
Country
China
ProdList
203
Advantage
58
Chengdu Biopurify Phytochemicals Ltd.
Tel
028-82633397-
Fax
+86-28-82633165
Email
daisy@biopurify.cn
Country
China
ProdList
2078
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43496
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
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View Lastest Price from Hypericin manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Hypericin 548-04-9 548-04-9
Price
US $650.00/g
Min. Order
10mg
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-06-27
Baoji Guokang Healthchem co.,ltd
Product
Hypericin 548-04-9
Price
US $130.00/ml
Min. Order
10ml
Purity
99%
Supply Ability
1kg
Release date
2021-06-07
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
Product
Hypericin 548-04-9
Price
US $1218.00/g
Min. Order
1g
Purity
98%
Supply Ability
1kg
Release date
2020-06-12

548-04-9, HypericinRelated Search:


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  • Hypericin 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione
  • Hypericin, >=98%
  • Hypericin CAS NO.548-04-9
  • PubChem ID: 5281051
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  • Phenanthro1,10,9,8-opqraperylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-, stereoisomer
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