Hypericin

ChemicalBook > CAS DataBase List > Hypericin

Hypericum perforatum extracts Indications Uses

Product Name: Hypericin
CAS No.: 548-04-9
Chemical Name: Hypericin
Synonyms: Hypericins;Hyperici;Hypericine;VIMRxyn;CYCLOSAN;ypericin;HYPERICIN;MYCOPOPHYRIN;CYCLO-WERROL;HYPERICIN(P)
CBNumber: CB2696784
Molecular Formula: C30H16O8
Formula Weight: 504.44
MOL File: 548-04-9.mol

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Hypericin Property

Melting point:: 299-301°C
Boiling point:: 1020.3±65.0 °C(Predicted)
Density: 1.915±0.06 g/cm3(Predicted)
RTECS: SF8472000
storage temp.: -20°C
solubility: 1 M NaOH: 10 mg/mL
form: powder
pka: 6.91±0.20(Predicted)
color: black
Water Solubility: Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water.
Sensitive: Light Sensitive
Merck: 14,4863
BRN: 1917913
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey: BTXNYTINYBABQR-UHFFFAOYSA-N
LogP: 10.827 (est)
CAS DataBase Reference: 548-04-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-40-43
Safety Statements: 22-36-36/37
RIDADR: 2811
WGK Germany: 3
F: 8
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89226
Product name: Hypericin
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $688
Updated: 2024/03/01

Sigma-Aldrich

Product number: 00190585
Product name: Hypericin
Purity: primary pharmaceutical reference standard
Packaging: 10mg
Price: $922
Updated: 2024/03/01

Alfa Aesar

Product number: H26425
Product name: Hypericin, 98%
Packaging: 25mg
Price: $750
Updated: 2024/03/01

Alfa Aesar

Product number: H26425
Product name: Hypericin, 98%
Packaging: 100mg
Price: $1716
Updated: 2024/03/01

Cayman Chemical

Product number: 11334
Product name: Hypericin
Purity: ≥95%
Packaging: 500μg
Price: $27
Updated: 2024/03/01

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Hypericin Chemical Properties,Usage,Production

Hypericum perforatum extracts

Hypericin is an extract of Hypericum perforatum L.In 1957. It is first isolated from the Garcinia species Hypericum perforatum by human beings. Hypericin belongs to the bianthrone compounds, and it is the most biologically active substances. Hypericin is a yellowish brown to brown mobile powder, with slightly bitter taste. It is soluble in water, and can emit a special fragrance. It can inhibit the central nervous and has a sedative effect. Adding it to health care products can enhance immunity. It is also used as antidepressant drugs in Europe (especially in Germany). Hypericin also has a strong anti-viral effect, which can directly act on swine fever, foot and mouth disease and other viruses. In addition, it also has a good effect on killing highly pathogenic avian influenza virus.
Hypericum perforatum is one of the world's best-selling herbs in recent years, mainly containing hyperoside, quercetin, chlorogenic acid, caffeic acid, imanin, hypericin and other ingredients.
Hypericin is a few thousandths of the whole Hypericum perforatum. There are certain requirements for its extraction and testing. Methanol extraction method is common used in the past. Due to the toxicity of methanol, now the method is converted to use ethanol to obtain the active ingredient.

Indications

Hypericin is an anti-virus and pure Chinese medicine preparations. It is the first choice for the prevention and treatment of avian influenza drugs.
1, avian influenza, atypical Newcastle disease, infectious bronchitis, avian infectious laryngotracheitis , bursa of Fabricius, duck plague, duck viral hepatitis, egg drop syndrome and other viral diseases.
2, poultry fever caused by high fever, dyspnea, cough, head and face swelling, crown hair purple, lack of energy, decreased feed intake, egg drop, producing more abnormal eggs.
3, for classical swine fever, blue ear disease, parvovirus, viral enteritis, infectious gastroenteritis and immune dysfunction.
4, Hypericin has a strong anti-viral effect both in vivo and in vitro. It has a strong inhibitory effect on the early replication of HIV. Hypericin can lead to cancer cell programmed death, with anti-cancer effect. It has a enhanced immune function for activating mononuclear phagocytic cells. In addition, it has a strong role in killing the highly pathogenic H5N1 and H9N2 subtype of avian influenza virus.

Uses

(1) Antidepressant, increase immunity.
(2) For the treatment of antidepressants, increase immunity.

Description

An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC₅₀ = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.

Chemical Properties

Powder

Uses

It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method.

Definition

ChEBI: Hypericin is a carbopolycyclic compound. It has a role as an antidepressant. It derives from a hydride of a bisanthene.

General Description

Produced by HWI Analytik
Exact content can be found on the certificate

Biological Activity

Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.

Biochem/physiol Actions

Primary TargetPKC

storage

+4°C

Purification Methods

Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.]

References

1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm. Des., 11 233 2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol. Pharmacol., 6 1775

Hypericin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Hypericin manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Hypericin 548-04-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-05

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Hypericin 548-04-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-29

Hebei Yanxi Chemical Co., Ltd.

Product: Hypericin 548-04-9
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-24

548-04-9, HypericinRelated Search:

Hyperoside Perylene Pseudohypericin Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ethyl isocyanoacetate TERT-BUTYL ISOCYANIDE Ferric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE N-BUTYLISOCYANIDE Aluminum acetylacetonate METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) COBALT(II) ACETYLACETONATE PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

HYPERICUM RED

HYPERICIN

HYPERICIN (NATIVE)

CYCLOSAN

CYCLO-WERROL

1,3,4,6,8,13-HEXAHYDROXY-10,11-DIMETHYLPHENANTHRO[1,10,9,8-OPQRA]PERYLENE-7,14-DIONE

1,3,4,6,8,13-HEXAHYDROXY-10,11-DIMETHYLPHENANTHROL(1,10,9,8,OPQRA)PERYLENE-7,14-DIONE

MYCOPOPHYRIN

MYCOPORPHYRIN

ST JOHN'S WORT POWDER

ST JOHN'S WORT EXTRACT

4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone

hypericinfromhypericumperforatum

1,3,4,6,8,13-Hexahydroxy-10,11-dimethyl-7,14-dihydrophenanthro[1,10,9,8-opqra]perylene-7,14-dione

HYPERICINRESEARCH GRADE

Cyclo-Werrol: Hypericum red

Hypericin / 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione / 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone

Hypericin 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione

Hypericin, >=98%

Hypericin CAS NO.548-04-9

PubChem ID: 5281051

Hypericin - CAS 548-04-9 - Calbiochem

Hypericin 548-04-9

Hypericin Hypericum perforatum

Hypericine

Hypericins

VIMRxyn

Phenanthro1,10,9,8-opqraperylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-, stereoisomer

ST.JOHNSWORTEXTRACT,4:1,POWDER

HYPERICIN(P)

STJOHN'SWORTHYPERICIN

HYPERICIN HPLC

Hypericin, Cyclo-Werrol

HYPERICIN WITH HPLC

dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-

Phenanthro [1,10,9,8-opqra]perylene-7,14-

Cyclo werrol, Hypericum red, 4,5,7,4μ,5μ,7μ-Hexahydroxy-2,2μ-dimethylnaphthodianthrone

Hypericin USP/EP/BP

1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione P-conformer

Hypericin (SGX301)

Hyperici

St John S wort extract, hypericin

ypericin

548-04-9

C30H16O8

50444

BioChemical

Biochemicals and Reagents

P to Q

Protein kinase C

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Nutraceuticals

Antitumour

Natural Plant Extract

Anthraquinones, Hydroquinones and Quinones

antibiotic