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LY 294002 Hydrochloride

Product Name
LY 294002 Hydrochloride
CAS No.
154447-36-6
Chemical Name
LY 294002 Hydrochloride
Synonyms
YX;CS-1859;SF 1101;LY240092;LY 294002;NSC 697286;LY294002HCl;LY294002/PI3K;LY 294002, 99+%;LY294002 ，S1105
CBNumber
CB1242450
Molecular Formula
C19H17NO3
Formula Weight
307.34
MOL File
154447-36-6.mol
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LY 294002 Hydrochloride Property

Melting point:
183-185℃
Boiling point:
494.6±45.0 °C(Predicted)
Density 
1.266
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: >5 mg/mL
form 
solid
pka
0.55±0.20(Predicted)
color 
white to off-white
Water Solubility 
Soluble in DMSO at 5mg/ml. Insoluble in water
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChI
InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey
CZQHHVNHHHRRDU-UHFFFAOYSA-N
SMILES
C1(N2CCOCC2)OC2=C(C3=CC=CC=C3)C=CC=C2C(=O)C=1
CAS DataBase Reference
154447-36-6
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Safety

Safety Statements 
24-25
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H320Causes eye irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H402Harmful to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
440202
Product name
LY 294002
Packaging
5mg
Price
$222
Updated
2025/07/31
Sigma-Aldrich
Product number
440202
Product name
LY 294002
Packaging
10mg
Price
$328
Updated
2025/07/31
Sigma-Aldrich
Product number
19-142
Product name
LY 294002
Packaging
1mg
Price
$187
Updated
2025/07/31
TCI Chemical
Product number
M2410
Product name
2-Morpholino-8-phenylchromone
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$219
Updated
2025/07/31
Cayman Chemical
Product number
70920
Product name
LY 294002
Purity
≥98%
Packaging
5mg
Price
$26
Updated
2024/03/01
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LY 294002 Hydrochloride Chemical Properties,Usage,Production

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

Uses

A potent blocker of PI 3-kinase/Akt signaling.

Uses

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Definition

ChEBI: LY294002 is a chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an autophagy inhibitor and a geroprotector. It is a member of chromones, a member of morpholines and an organochlorine compound.

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

target

p110α

References

[1] C. VLAHOS. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).[J]. The Journal of Biological Chemistry, 1994, 93 1: 5241-5248. DOI:10.1016/s0021-9258(17)37680-9.
[2] SEVERINE I GHARBI. Exploring the specificity of the PI3K family inhibitor LY294002.[J]. ACS Applied Energy Materials, 2007: 15-21. DOI:10.1042/BJ20061489.
[3] SANCHEZMARGALET V. Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002[J]. Biochemical and biophysical research communications, 1994, 204 2: Pages 446-452. DOI:10.1006/bbrc.1994.2480.

LY 294002 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 294002 Hydrochloride Suppliers

Americas 1 Australia 1 China 340 China Hong Kong 1 Europe 1 Germany 4 India 2 Japan 4 Switzerland 2 United Kingdom 10 United States 41 Global 407
Zhengzhou HSH Science & Technology Co., Ltd.
Tel
0371-55932928 18937192232
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0086-0371-55932928
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1282296214@qq.com
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China
ProdList
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TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
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Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
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55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
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3bsc@sina.com
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China
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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6003
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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66
Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
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JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
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View Lastest Price from LY 294002 Hydrochloride manufacturers

Career Henan Chemical Co
Product
LY 294002 HYDROCHLORIDE 154447-36-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

154447-36-6, LY 294002 HydrochlorideRelated Search:

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  • LY 294002
  • LY 294002 HYDROCHLORIDE
  • 2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE
  • 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE
  • 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • CS-1859
  • LY294002 (HCl Salt)
  • 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ON
  • InSolution LY 294002 - CAS 154447-36-6 - Calbiochem
  • LY 294002 - CAS 154447-36-6 - Calbiochem
  • LY 294002, 99+%
  • LY294002HCl
  • 2-(4-morpholinyl)-8-phenyl-1(4h)-benzopyran-4-one hydrochloride
  • LY-294002;LY 294002;LY 294002 HYDROCHLORIDE;2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE;2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • 8-Phenyl-2-(morpholin-4-yl)chromen-4-one
  • 2-[4-Morpholinyl]-8-phenyl-1[4H]-benzopyran-4-on
  • NSC 697286
  • SF 1101
  • 2-Morpholino-8-phenyl-4H-chroMen-4-one
  • 2-Morpholino-8-phenylchroMone
  • 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 294002
  • LY 294002 8-Phenyl-2-(morpholin-4-yl)chromen-4-one
  • LY294002 (HCI Salt)
  • LY240092
  • LY294002, NSC 697286
  • 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran
  • InSolution? LY 294002
  • 2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-on
  • NSC 697286; SF 1101; LY 294002; LY-294002
  • Morpholino phenylchromone
  • 2-Morpholino-8-phenylchromone&gt
  • 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-
  • YX
  • LY294002/PI3K
  • LY 294002 HYDROCHLORIDE USP/EP/BP
  • LY 294002, Free Base
  • LY 294002 (DMSO solution)
  • LY 294002 (DMSO solution), PI3-kinase inhibitor
  • LY294002, 10 mM in DMSO
  • PI3K inhibitor kit
  • LY294002 ，S1105
  • 154447-36-6
  • C19H18ClNO3HCl
  • C19H17O3N
  • Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Kinase/Phosphatase Biology
  • Phosphatidylinositol 3-kinase (PI3K)
  • Serine/Threonine Kinase Inhibitors
  • PI3K/Akt Signaling
  • Inhibitors
  • Inhibitor
  • Anti-cancer&immunity
  • PI3K/Akt/mTOR
  • Akt