LY 2784544

Product Name: LY 2784544
CAS No.: 1229236-86-5
Chemical Name: LY 2784544
Synonyms: Gandotinib (LY2784544);3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine LY 2784544;CS-13;LY2874544;LY 2784544;LY2784544/LY-2784544;LY2784544(gandotinib);Gandotinib, 10 mM in DMSO;Gandotinib LY2784544 LY-2784544;3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[
CBNumber: CB52514748
Molecular Formula: C23H25ClFN7O
Formula Weight: 469.94
MOL File: 1229236-86-5.mol

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LY 2784544 Property

Density: 1.45
storage temp.: Store at -20°C
solubility: ≥23.5 mg/mL in DMSO; insoluble in H2O; ≥5.65 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 14.12±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2567
Product name: LY2784544
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $148
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2567
Product name: LY2784544
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $285
Updated: 2024/03/01

Cayman Chemical

Product number: 16705
Product name: LY2784544
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16705
Product name: LY2784544
Purity: ≥98%
Packaging: 5mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 16705
Product name: LY2784544
Purity: ≥98%
Packaging: 10mg
Price: $239
Updated: 2024/03/01

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LY 2784544 Chemical Properties,Usage,Production

Uses

LY2784544 is a JAK2 inhibitor. LY2784544 may be used as a potential treatment for patients with myeloproliferative neoplasm.

Definition

ChEBI: Gandotinib is a member of pyridazines.

Biological Activity

LY2784544 is an orally active, ATP-competitive, potent and JAK2-selective janus tyrosine kinase inhibitor (IC50/[ATP] = 2.52 nM/5 μM/JAK2, 19.8 nM/20 μM/JAK1, 48.0 nM/2 μM/JAK3) with little activity toward 79 other kinases. LY2784544 selectively inhibits signaling/proliferation driven by oncogenic JAK2V617F (IC50 = 20/55 nM) over those mediated by wt JAK2 upon IL-3 induction (IC50 = 1183/1309 nM) in Ba/F3 cultures and displays in vivo efficacious in a JAK2V617F-induced murine MPN model (10-80 mg/kg bid po.). LY2784544 is also reported to display Zn-dependent (optimal [Zn+2] = 100 μM) GPR39 agonist activity, but not 11 other GPRs.

target

wild-type JAK2

LY 2784544 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 2784544 Suppliers

China 139 India 2 United Kingdom 1 United States 21 Global 163

Shandong Yongxin Biotechnology Co., Ltd

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Shanghai Boyle Chemical Co., Ltd.

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Jinan Trio PharmaTech Co., Ltd.

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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

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View Lastest Price from LY 2784544 manufacturers

Apeloa production Co.,Limited

Product: LY2784544 1229236-86-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000
Release date: 2024-06-17

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Tucatinib；LY 2784544 1229236-86-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-07

Career Henan Chemical Co

Product: LY 2784544 1229236-86-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

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LY 2784544

3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine

3-(4-chloro-2-fluorobenzyl)-2-Methyl-N-(3-Methyl-1H-pyrazol-5-yl)-8-(MorpholinoMethyl)iMidazo[1,2-b]pyridazin-6-aMine

LY2784544/LY-2784544

IMidazo[1,2-b]pyridazin-6-aMine, 3-[(4-chloro-2-fluorophenyl)Methyl]-2-Methyl-N-(5-Methyl-1H-pyrazol-3-yl)-8-(4-MorpholinylMethyl)-

LY2874544

CS-13

Gandotinib (LY2784544)

3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine LY 2784544

LY2784544(gandotinib)

3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[

3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

Gandotinib LY2784544 LY-2784544

VEGFR,inhibit,FGFR,LY-2784544,Janus kinase,CD135,FLT3,Cluster of differentiation antigen 135,LY 2784544,Inhibitor,Gandotinib,Fms like tyrosine kinase 3,Vascular endothelial growth factor receptor,JAK,Fibroblast growth factor receptor

Gandotinib, 10 mM in DMSO

1229236-86-5

C23H25ClFN7O

Inhibitors

JAK

STAT

Inhibitor

JAK/STAT