LY 2606368
- Product Name
- LY 2606368
- CAS No.
- 1234015-52-1
- Chemical Name
- LY 2606368
- Synonyms
- CS-1453;LY 2606368;Prexasertib;Prexasertib free base;Prexasertib (LY2606368);LY 2606368;LY-2606368;PREXASERTIB;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile;5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile LY2606368
- CBNumber
- CB82667926
- Molecular Formula
- C18H19N7O2
- Formula Weight
- 365.39
- MOL File
- 1234015-52-1.mol
LY 2606368 Property
- Boiling point:
- 608.5±55.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in DMSO
- form
- A crystalline solid
- pka
- 11.89±0.10(Predicted)
- color
- Light yellow to brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21490
- Product name
- LY2606368
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 21490
- Product name
- LY2606368
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $486
- Updated
- 2024/03/01
- Product number
- 21490
- Product name
- LY2606368
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $799
- Updated
- 2024/03/01
- Product number
- 21490
- Product name
- LY2606368
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1141
- Updated
- 2024/03/01
- Product number
- 454002
- Product name
- LY 2606368
- Packaging
- 500ug
- Price
- $566
- Updated
- 2021/12/16
LY 2606368 Chemical Properties,Usage,Production
Description
LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of <13 nM in a viability study of multiple colorectal cancer cell lines. Inhibition of Chk1 causes double-strand DNA breakage in cells leading to an excessive cell damage burden and subsequent cell death. In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.
Uses
LY 2606368 is a novel CHK1 inhibitor under investigation as a chemopotentiating agent. It causes double-stranded DNA breakage while simultaneously removing the protection of the DNA damage checkpoints. LY 2606368 is representative of a novel class of drugs for the treatment of cancer and tumor growth inhibition.
References
[1] wu w, bi c, bence a k, et al. antitumor activity of chk1 inhibitor ly2606368 as a single agent in sw1990 human pancreas orthotopic tumor model. cancer research, 2012, 72(8 supplement): 1776.
[2] lainchbury m, matthews t p, mchardy t, et al. discovery of 3-alkoxyamino-5-(pyridin-2-ylamino) pyrazine-2-carbonitriles as selective, orally bioavailable chk1 inhibitors. journal of medicinal chemistry, 2012, 55(22): 10229-10240.
[3] mcneely s c, burke t f, durlandbusbice s, et al. abstract a108: ly2606368, a second generation chk1 inhibitor, inhibits growth of ovarian carcinoma xenografts either as monotherapy or in combination with standard-of-care agents. molecular cancer therapeutics, 2011, 10(supplement 1): a108.
LY 2606368 Preparation Products And Raw materials
Raw materials
Preparation Products
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