LY 379268
- Product Name
- LY 379268
- CAS No.
- 191471-52-0
- Chemical Name
- LY 379268
- Synonyms
- CS-1087;LY397268;LY 379268;(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid;2-Oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid,4-amino-,(1R,4R,5S,6R)-
- CBNumber
- CB5841046
- Molecular Formula
- C7H9NO5
- Formula Weight
- 187.15
- MOL File
- 191471-52-0.mol
LY 379268 Property
- Boiling point:
- 413.9±45.0 °C(Predicted)
- Density
- 1.716±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Soluble in H2O or NaOH
- form
- solid
- pka
- 1.81±0.40(Predicted)
- color
- White
- Water Solubility
- Soluble to 20 mM in water and to 100 mM in 1eq. NaOH
N-Bromosuccinimide Price
- Product number
- 15351
- Product name
- LY379268
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 15351
- Product name
- LY379268
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $200
- Updated
- 2024/03/01
- Product number
- 15351
- Product name
- LY379268
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $326
- Updated
- 2024/03/01
- Product number
- 2453
- Product name
- LY379268
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $392
- Updated
- 2021/12/16
- Product number
- 2453
- Product name
- LY379268
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $1649
- Updated
- 2021/12/16
LY 379268 Chemical Properties,Usage,Production
Uses
LY 379268 is a group II metabotropic glutamate receptors (mGlu2/3) receptor agonist (1,2). Studies have shown that LY379268 significantly attenuated cocaine-induced increases in DA in nonhuman primates.
Definition
ChEBI: LY 379268 is an organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. It has a role as a metabotropic glutamate receptor agonist, a neuroprotective agent, an antipsychotic agent and an anxiolytic drug. It is an organic heterobicyclic compound, a bridged compound and an amino dicarboxylic acid.
Biological Activity
Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active.
storage
Store at +4°C
LY 379268 Preparation Products And Raw materials
Raw materials
Preparation Products
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