ChemicalBook > CAS DataBase List > LY 379268

LY 379268

Product Name
LY 379268
CAS No.
191471-52-0
Chemical Name
LY 379268
Synonyms
CS-1087;LY397268;LY 379268;LY 379268, Group II mGlu agonist;(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid;2-Oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid,4-amino-,(1R,4R,5S,6R)-
CBNumber
CB5841046
Molecular Formula
C7H9NO5
Formula Weight
187.15
MOL File
191471-52-0.mol
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LY 379268 Property

Boiling point:
413.9±45.0 °C(Predicted)
Density 
1.716±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble in H2O or NaOH
form 
solid
pka
1.81±0.40(Predicted)
color 
White
Water Solubility 
Soluble to 20 mM in water and to 100 mM in 1eq. NaOH
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15351
Product name
LY379268
Purity
≥99%
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
15351
Product name
LY379268
Purity
≥99%
Packaging
5mg
Price
$200
Updated
2024/03/01
Cayman Chemical
Product number
15351
Product name
LY379268
Purity
≥99%
Packaging
10mg
Price
$326
Updated
2024/03/01
Tocris
Product number
2453
Product name
LY379268
Purity
≥99%(HPLC)
Packaging
10
Price
$392
Updated
2021/12/16
Tocris
Product number
2453
Product name
LY379268
Purity
≥99%(HPLC)
Packaging
50
Price
$1649
Updated
2021/12/16
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LY 379268 Chemical Properties,Usage,Production

Uses

LY 379268 is a group II metabotropic glutamate receptors (mGlu2/3) receptor agonist (1,2). Studies have shown that LY379268 significantly attenuated cocaine-induced increases in DA in nonhuman primates.

Definition

ChEBI: LY 379268 is an organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. It has a role as a metabotropic glutamate receptor agonist, a neuroprotective agent, an antipsychotic agent and an anxiolytic drug. It is an organic heterobicyclic compound, a bridged compound and an amino dicarboxylic acid.

Biological Activity

Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active.

in vivo

For LY379268, when a 3?mg/kg dose is given prior to an intraplantar injection of carrageenan, the inflammatory hyperalgesia that developed is significantly delayed, without affecting the inflammation of the paw[2].
In a model of mouse tail withdrawal to warm water, LY379268 (12?mg/kg; i.p.), given before a subcutaneous tail injection of capsaicin, reduces the subsequent neurogenic hyperalgesia[2].

IC 50

hmGluR2: 2.69 nM (EC50); hmGluR3: 4.48 nM (EC50); hmGluR2: 14.1 nM (Ki); hmGluR3: 5.8 nM (Ki)

storage

Store at +4°C

LY 379268 Preparation Products And Raw materials

Raw materials

Preparation Products

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191471-52-0, LY 379268Related Search:

LY 294002 Hydrochloride 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE LY-404039 LY3143921 LY 2606368 LY-2940094 LY2109761 3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID (2S,3S,4S)-2-METHYL-2-(CARBOXYCYCLOPROPYL)GLYCINE DL-2-ISOPROPYLSERINE (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE L-2-Aminoadipic acid DL-2-ISOBUTYLSERINE LY 379268

  • LY 379268
  • 2-Oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid,4-amino-,(1R,4R,5S,6R)-
  • (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid
  • LY397268
  • CS-1087
  • LY 379268, Group II mGlu agonist
  • 191471-52-0
  • AMINOACID
  • Glutamate