1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

Product Name: 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
CAS No.: 117690-79-6
Chemical Name: 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE
Synonyms: LY 255283;CGS 23356;LY255283 ，S2959;LY255283, 10 mM in DMSO;LY255283, BLT2 receptor antagonist;5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone;1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE;1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE;parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283
CBNumber: CB9257308
Molecular Formula: C19H28N4O3
Formula Weight: 360.45
MOL File: 117690-79-6.mol

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1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Property

Melting point:: 160-162 °C
Boiling point:: 573.4±60.0 °C(Predicted)
Density: 1.157±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: >20mg/mL
pka: 5.11±0.10(Predicted)
form: powder
color: off-white to light yellow

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Safety

WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L1920
Product name: LY255283
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $183
Updated: 2025/07/31

Sigma-Aldrich

Product number: L1920
Product name: LY255283
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $634
Updated: 2022/05/15

Cayman Chemical

Product number: 70715
Product name: LY255283
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 70715
Product name: LY255283
Purity: ≥98%
Packaging: 5mg
Price: $94
Updated: 2024/03/01

Cayman Chemical

Product number: 70715
Product name: LY255283
Purity: ≥98%
Packaging: 10mg
Price: $140
Updated: 2024/03/01

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1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Chemical Properties,Usage,Production

Description

Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B₄ (LTB₄) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT₂ receptor. It displaces radiolabeled LTB₄ from guinea pig lung membrane, with an IC₅₀ of about 100 nM. LY255283 exhibits IC₅₀ values of ~950 nM and >10 μM at human recombinant BLT₂ and BLT₁ receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB₄ to eosinophil membranes with an IC₅₀ of 260 nM.

Uses

LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia.

Definition

ChEBI: 1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone is an aromatic ketone.

Biological Activity

Selective, competitive antagonist of BLT 2 receptors (IC 50 values are ~ 1 and > 10 μ M at human recombinant BLT 2 and BLT 1 receptors respectively). Inhibits LTB 4 -induced contraction of lung parenchyma (pA 2 = 7.2), and reduces LTB 4 -mediated airway obstruction in guinea pigs following i.v. and oral administration.

storage

Store at +4°C

References

[1] STEVEN A. SILBAUGH . Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist[J]. European journal of pharmacology, 1992, 223 1: Pages 57-64. DOI: 10.1016/0014-2999(92)90818-o
[2] IVAN M. RICHARDS. Contribution of Leukotriene B4 to Airway Inflammation and the Effect of Antagonists[J]. Annals of the New York Academy of Sciences, 1991, 629 1: 274-287. DOI: 10.1111/j.1749-6632.1991.tb37983.x

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE Suppliers

China 60 Europe 1 Germany 3 United Kingdom 2 United States 12 Global 78

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117690-79-6, 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONERelated Search:

PROSTAGLANDIN F1ALPHA Latanoprost Misoprostol Acid 13,14-DIHYDROPROSTAGLANDIN E1 Sulprostone PROSTAGLANDIN B1 Fluprostenol Prostaglandin F2a PROSTAGLANDIN D2 PROSTAGLANDIN A1 LY2109761 LY-2940094 LY 379268 LY 2606368 LY3143921 LY-404039 LY 294002 Hydrochloride SC-51089

LY 255283

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE

1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOLE-5-YL)HEPTYL]OXY]PHENYL]-ETHANONE

5'-Ethyl-2'-hydroxy-4'-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone

CGS 23356

1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone

Ethanone, 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]phenyl]-

1-(5-Ethyl-2-hydroxy-4-((6-methyl-6-(2H-tetrazol-5-yl)heptyl)oxy)phenyl)ethan-1-one

parcnchyma,LTB4,Leukotriene Receptor,inhibit,BLT2,LY255283,lung,Inhibitor,LY-255283

LY255283, BLT2 receptor antagonist

LY255283, 10 mM in DMSO

LY255283 ，S2959

117690-79-6

C19H28N4O3

Prostanoid receptor and related