Misoprostol Acid
- Product Name
- Misoprostol Acid
- CAS No.
- 112137-89-0
- Chemical Name
- Misoprostol Acid
- Synonyms
- MISOPROSTOL ACID;MISOPROSTOL FREE ACID;8-iso Misoprostol acid;Misoprostol Acid USP/EP/BP;Misoprostol acid,racemic mixture;Misoprostol Acid, Technical Grade 65%;Misoprostol Acid (10 mg in 1 mL Methyl Acetate);(-15-Deoxy-(16RS)-16-hydroxy-16-methylprogestaglandin E;(+-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDINE1;(+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1
- CBNumber
- CB0713294
- Molecular Formula
- C21H36O5
- Formula Weight
- 368.51
- MOL File
- 112137-89-0.mol
Misoprostol Acid Property
- Boiling point:
- 538.3±50.0 °C(Predicted)
- Density
- 1.118±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform
- form
- Yellow viscous oil.
- pka
- 4.77±0.10(Predicted)
- color
- Pale Yellow
- Stability:
- Temperature Sensitive
Safety
- Hazard Codes
- T
- Risk Statements
- 45-60-61-25-36/37/38
- Safety Statements
- 53-22-36/37/39-45-26
- RIDADR
- UN 2810 6.1/PG 3
- WGK Germany
- 2
- HazardClass
- 6.1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M6932
- Product name
- Misoprostol free acid
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $193
- Updated
- 2025/07/31
- Product number
- 13821
- Product name
- Misoprostol (free acid)
- Purity
- ≥97%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 13821
- Product name
- Misoprostol (free acid)
- Purity
- ≥97%
- Packaging
- 5mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 13821
- Product name
- Misoprostol (free acid)
- Purity
- ≥97%
- Packaging
- 10mg
- Price
- $469
- Updated
- 2024/03/01
- Product number
- 13821
- Product name
- Misoprostol (free acid)
- Purity
- ≥97%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2024/03/01
Misoprostol Acid Chemical Properties,Usage,Production
Description
Misoprostol is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-
Chemical Properties
Pale Yellow Gel
Uses
A metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration
Uses
A cytoprotective prostaglandin PGE1 analogue.
Uses
Misoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.
Biochem/physiol Actions
Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent.
in vivo
Unlike the Misoprostol, Misoprostol acid is detectable in plasma. Misoprostol is a lipophilic methyl ester prodrug and is readily metabolized to the free acid, which is the biologically active form. Misoprostol is used worldwide for a variety of indications in obstetrics and gynecology. Misoprostol has both gastric antisecretory and mucosal protective effects[1].
IC 50
EP
References
[1] WALT R P. Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration.[J]. New England Journal of Medicine, 1992, 327 22: 1575-1580. DOI: 10.1056/nejm199211263272207
[2] K T BUNCE. GR63799X–a novel prostanoid with selectivity for EP3 receptors.[J]. Advances in prostaglandin, thromboxane, and leukotriene research, 1991, 21A: 379-382.
[3] E. TALPAIN. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils[J]. British Journal of Pharmacology, 1995, 114 7: 1459-1465. DOI: 10.1111/j.1476-5381.1995.tb13370.x
[4] G C SMITH J C M R A Coleman. Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 1: 390-396.
Misoprostol Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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