(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide

Product Name: (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
CAS No.: 1346133-11-6
Chemical Name: (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
Synonyms: FP3FBZ;LY2444296;Ly2444296 (fp3fbz);LY2444296, 10 mM in DMSO;(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide;3-fluoro-4-(4-{[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]methyl}phenoxy)benzamide;Benzamide, 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]-
CBNumber: CB24858724
Molecular Formula: C24H22F2N2O2
Formula Weight: 408.44
MOL File: 1346133-11-6.mol

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(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Property

Boiling point:: 491.6±45.0 °C(Predicted)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol: 27.5 mg/mL (67.33 mM); Methanol: 5 mg/mL (12.24 mM)
pka: 15.61±0.50(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2452
Product name: LY2444296
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $84.83
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2452
Product name: LY2444296
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $360
Updated: 2025/07/31

ChemScene

Product number: CS-0110108
Product name: LY2444296
Purity: 99.78%
Packaging: 50mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-0110108
Product name: LY2444296
Purity: 99.78%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0110108
Product name: LY2444296
Purity: 99.78%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Chemical Properties,Usage,Production

Uses

LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ～1 nM. LY2444296 exhibits anti-anxiety like effects[1][2].

Biological Activity

LY2444296 is a brain-penetrant, orally active, short-acting, high-affinity, potent and selective K (kappa) opioid receptor (KOR) antagonist (human K/μ/δ Ki = 0.565/35.8/211 nM against diprenorphine binding; GTP-γ-S binding IC50/agonist/subtype transfectant = 1.57 nM/300 nM U69593/K, 21.3 nM/1 μM DAMGO/μ 293 nM/30 nM DPDPE/d). LY2444296 reverses K agonist antinociceptive efficacy in vivo (ED50 = 0.24 mg/kg p.o. against 1 mg/kg U69593 sc. by r at formalin test), decreases immobility time (10 or 30 mg/kg sc.) and prevents enhanced alcohol consumption (5 mg/kg i.p.) among mice subjected to stress by forced swimming.

in vivo

LY2444296 displays anti-anxiety like effects in the EPM test^[1].
LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-na?ve rats^[2].
LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-na?ve rats^[2].

Animal Model:	Adult male Sprague Dawley rats (240–250 g)^[2]
Dosage:	3 mg/kg
Administration:	Injected intraperitoneally; 30 min before U69,593 administration
Result:	Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-na?ve rats.

IC 50

κ Opioid Receptor/KOR

References

[1] Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20. DOI:10.1016/j.neulet.2016.01.017
[2] Valenza M, et al. "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology (Berl). 2017 Aug;234(15):2219-2231. DOI:10.1007/s00213-017-4647-0

(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Suppliers

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1346133-11-6, (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamideRelated Search:

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(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide

LY2444296

FP3FBZ

Benzamide, 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]-

3-fluoro-4-(4-{[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]methyl}phenoxy)benzamide

LY2444296, 10 mM in DMSO

Ly2444296 (fp3fbz)

1346133-11-6