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LY2584702

Product Name
LY2584702
CAS No.
1082949-67-4
Chemical Name
LY2584702
Synonyms
CS-1752;LY2584702;LY2584702 BASE;LY2584702 TsOH;LY2584702 ，S7698;LY2584702 USP/EP/BP;LY-2584702 (free base);LYS6K2, S6 kinase inhibitor;LY-2584702 free base (LY2584702);LY-2584702 free base, 10 mM in DMSO
CBNumber
CB52728813
Molecular Formula
C21H19F4N7
Formula Weight
445.42
MOL File
1082949-67-4.mol
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LY2584702 Property

storage temp. 
RT (des.)
solubility 
Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
form 
solid
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
L486540
Product name
LY2584702
Packaging
10mg
Price
$155
Updated
2021/12/16
TRC
Product number
L486540
Product name
LY2584702
Packaging
25mg
Price
$360
Updated
2021/12/16
Apolloscientific
Product number
BISN0247
Product name
Ly2584702
Packaging
25mg
Price
$348
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0002488
Product name
LY-2584702
Purity
95.00%
Packaging
5MG
Price
$497.65
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611834
Product name
LY-2584702 free base
Packaging
50mg
Price
$584.8
Updated
2021/12/16
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LY2584702 Chemical Properties,Usage,Production

Description

LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.

Uses

LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.

in vivo

LY-2584702 demonstrates significant single-agent efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models at two dose levels of 2.5 mg/kg twice daily (BID) and 12.5 mg/kg BID. LY-2584702 demonstrates statistically significant tumour growth reduction at TMED50 (threshold minimum effective dose 50%) (2.3 mg/kg) and TMED90 (10 mg/kg) in the HCT116 colon carcinoma xenograft model[1]. To examine the role of S6K in vivo, EOMA cells expressing shAkt3 are implanted in nu/nu mice, then treated for 14 days with LY-2584702 or Rapamycin. Analysis of tumors removed after 14 days shows that LY-2584702 inhibits S6 phosphorylation almost as effectively as Rapamycin. Loss of Akt3 increases tumor growth as compared with pLKO. LY-2584702 treatment alone does not significantly affect the growth of pLKO tumors. However, LY-2584702 significantly reduces the growth of tumors with shAkt3[2].

IC 50

p70S6K: 4 nM (IC50)

References

[1] TIM R. FENTON  Ivan T G. Functions and regulation of the 70 kDa ribosomal S6 kinases[J]. International Journal of Biochemistry & Cell Biology, 2011, 43 1: Pages 47-59. DOI:10.1016/j.biocel.2010.09.018
[2] SHIJIE LI  Joseph L G  Michael S Brown. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 8: 3441-3446. DOI:10.1073/pnas.0914798107

LY2584702 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2584702 Suppliers

China 71 The Netherlands 1 United States 16 Global 88
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai XR Chemical Technology Co., Ltd.
Tel
021-31007982 18019432809
Fax
021-31007982
Email
info@xrpharma.com
Country
China
ProdList
676
Advantage
55
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
Country
China
ProdList
472
Advantage
55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55

1082949-67-4, LY2584702Related Search:

LY2828360 LY-2562175 LY2228820 Etalocib 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol LY3214996 LY 2784544 LY2409881 trihydrochloride LY-364947 LY 88074 (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Everolimus Y27632 (hydrochloride) Verteporfin SB 431542 ABT 737 LY 294002 Hydrochloride

  • LY2584702
  • LY-2584702 (free base)
  • LY2584702 TsOH
  • 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702
  • 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
  • 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo
  • LY2584702 BASE
  • LY-2584702 free base (LY2584702)
  • CS-1752
  • 1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-
  • LY2584702 USP/EP/BP
  • Ribosomal S6 Kinase (RSK),LY2584702,LY 2584702,S6K,Inhibitor,inhibit,LY2584702 free base,LY 2584702 free base,LY-2584702
  • LYS6K2, S6 kinase inhibitor
  • LY-2584702 free base, 10 mM in DMSO
  • LY2584702 ，S7698
  • 1082949-67-4
  • C21H19F4N7
  • Inhibitors