LY2584702

ChemicalBook > CAS DataBase List > LY2584702

Product Name: LY2584702
CAS No.: 1082949-67-4
Chemical Name: LY2584702
Synonyms: CS-1752;LY2584702;LY2584702 BASE;LY2584702 TsOH;LY2584702 USP/EP/BP;LY-2584702 (free base);LYS6K2, S6 kinase inhibitor;LY-2584702 free base (LY2584702);4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
CBNumber: CB52728813
Molecular Formula: C21H19F4N7
Formula Weight: 445.42
MOL File: 1082949-67-4.mol

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LY2584702 Property

storage temp.: RT (des.)
solubility: Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
form: solid
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: L486540
Product name: LY2584702
Packaging: 10mg
Price: $155
Updated: 2021/12/16

TRC

Product number: L486540
Product name: LY2584702
Packaging: 25mg
Price: $360
Updated: 2021/12/16

Apolloscientific

Product number: BISN0247
Product name: Ly2584702
Packaging: 25mg
Price: $348
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0002488
Product name: LY-2584702
Purity: 95.00%
Packaging: 5MG
Price: $497.65
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611834
Product name: LY-2584702 free base
Packaging: 50mg
Price: $584.8
Updated: 2021/12/16

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LY2584702 Chemical Properties,Usage,Production

Description

LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.

Uses

LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.

References

1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441

LY2584702 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2584702 Suppliers

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1082949-67-4, LY2584702Related Search:

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LY2584702

LY-2584702 (free base)

LY2584702 TsOH

4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702

4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine

4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo

LY2584702 BASE

LY-2584702 free base (LY2584702)

CS-1752

1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-

LY2584702 USP/EP/BP

Ribosomal S6 Kinase (RSK),LY2584702,LY 2584702,S6K,Inhibitor,inhibit,LY2584702 free base,LY 2584702 free base,LY-2584702

LYS6K2, S6 kinase inhibitor

1082949-67-4

C21H19F4N7

Inhibitors