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LY2828360

Product Name
LY2828360
CAS No.
1231220-79-3
Chemical Name
LY2828360
Synonyms
CS-2878;LY2828360;LY2828360, 10 mM in DMSO;Inhibitor,LY2828360,inhibit,LY-2828360,LY 2828360,Cannabinoid Receptor;8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine;9H-Purine, 8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-
CBNumber
CB93040565
Molecular Formula
C22H27ClN6O
Formula Weight
426.94
MOL File
1231220-79-3.mol
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LY2828360 Property

Boiling point:
541.8±60.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Chloroform: 30 mg/ml
form 
A crystalline solid
pka
7.15±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26791
Product name
LY2828360
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26791
Product name
LY2828360
Packaging
25mg
Price
$571
Updated
2024/03/01
Cayman Chemical
Product number
26791
Product name
LY2828360
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
26791
Product name
LY2828360
Packaging
10mg
Price
$243
Updated
2024/03/01
AK Scientific
Product number
8271DG
Product name
8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine
Packaging
10mg
Price
$370
Updated
2021/12/16
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LY2828360 Chemical Properties,Usage,Production

Uses

LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

Biological Activity

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist th at inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.

in vivo

In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical and cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical and cold hypersensitivities and suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB2KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical and cold allodynia in WT mice but not in CB2KO mice previously render tolerant to morphine[1].

References

[1] Lin X, et al. Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. Mol Pharmacol. 2018 Feb;93(2):49-62. DOI:10.1124/mol.117.109355

LY2828360 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2828360 Suppliers

China 33 United States 7 Global 40
Shanghai Boyle Chemical Co., Ltd.
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Fax
86-21-57758967
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sales@boylechem.com
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China
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2922
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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4757
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55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
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QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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9126
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Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
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32435
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58
InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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United States
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6391
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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CHINA
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Shanghai Dongyang Biotechnology Co., Ltd.
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0512-0512-13601744364 13601744364
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chemsharker@126.com
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China
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1010
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Changzhou Chenhong Biotechnology Co., Ltd.
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+86-0519-85788828 +86-13775037613
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sales@chemrenpharm.com
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China
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3934
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1231220-79-3, LY2828360Related Search:

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  • LY2828360
  • 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine
  • CS-2878
  • 9H-Purine, 8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-
  • Inhibitor,LY2828360,inhibit,LY-2828360,LY 2828360,Cannabinoid Receptor
  • LY2828360, 10 mM in DMSO
  • 1231220-79-3