LY2828360

Product Name: LY2828360
CAS No.: 1231220-79-3
Chemical Name: LY2828360
Synonyms: CS-2878;LY2828360;LY2828360, 10 mM in DMSO;Inhibitor,LY2828360,inhibit,LY-2828360,LY 2828360,Cannabinoid Receptor;8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine;9H-Purine, 8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-
CBNumber: CB93040565
Molecular Formula: C22H27ClN6O
Formula Weight: 426.94
MOL File: 1231220-79-3.mol

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LY2828360 Property

Boiling point:: 541.8±60.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Chloroform: 30 mg/ml
form: A crystalline solid
pka: 7.15±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26791
Product name: LY2828360
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26791
Product name: LY2828360
Packaging: 25mg
Price: $571
Updated: 2024/03/01

Cayman Chemical

Product number: 26791
Product name: LY2828360
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 26791
Product name: LY2828360
Packaging: 10mg
Price: $243
Updated: 2024/03/01

AK Scientific

Product number: 8271DG
Product name: 8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine
Packaging: 10mg
Price: $370
Updated: 2021/12/16

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LY2828360 Chemical Properties,Usage,Production

Uses

LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB2) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

Biological Activity

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist th at inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.

in vivo

In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical and cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical and cold hypersensitivities and suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB₂KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical and cold allodynia in WT mice but not in CB₂KO mice previously render tolerant to morphine^[1].

References

[1] Lin X, et al. Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. Mol Pharmacol. 2018 Feb;93(2):49-62. DOI:10.1124/mol.117.109355

LY2828360 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2828360 Suppliers

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LY2828360

8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine

CS-2878

9H-Purine, 8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-

Inhibitor,LY2828360,inhibit,LY-2828360,LY 2828360,Cannabinoid Receptor

LY2828360, 10 mM in DMSO

1231220-79-3