LY-2940094

Product Name: LY-2940094
CAS No.: 1307245-86-8
Chemical Name: LY-2940094
Synonyms: BTRX-246040;LY2940094, 10 mM in DMSO;LY2940094;BTRX 246040;LY-2940094;LY 2940094;(2-(4-((2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol;2-[4-[(2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-yl)methyl]-3-methyl-1H-pyrazol-1-yl]-3-pyridinemethanol;3-Pyridinemethanol, 2-[4-[(2'-chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-yl)methyl]-3-methyl-1H-pyrazol-1-yl]-;depressive,orally ethanol,self-administration,Inhibitor,brain,BTRX 246040,Opioid Receptor,inhibit,penetrate,BTRX-246040,LY2940094,LY 2940094,BTRX246040,major,disorder
CBNumber: CB94843927
Molecular Formula: C22H23ClF2N4O2S
Formula Weight: 480.96
MOL File: 1307245-86-8.mol

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LY-2940094 Property

Boiling point:: 631.3±55.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 41.67 mg/mL (86.64 mM)
form: Solid
pka: 13.27±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC76645
Product name: LY 2940094
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0085528
Product name: LY2940094
Purity: 99.56%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

AK Scientific

Product number: 1234DJ
Product name: LY-2940094
Packaging: 5mg
Price: $387
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0045911
Product name: LY-2940094
Purity: 95.00%
Packaging: 5MG
Price: $455.77
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC76645
Product name: LY 2940094
Packaging: 10mg
Price: $470
Updated: 2021/12/16

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LY-2940094 Chemical Properties,Usage,Production

Uses

LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models[1].

in vivo

LY2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity^[1].

Animal Model:	Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)^[1]
Dosage:	3, 10, or 30 mg/kg; 2-3 mL/kg
Administration:	Administered orally; daily; 4 days
Result:	Reduced homecage ethanol self-administration.

IC 50

NOP Receptor/ORL1

References

[1] Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. DOI:10.1111/acer.13052

LY-2940094 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY-2940094 Suppliers

China 40 United States 3 Global 43

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LY2940094;BTRX 246040;LY-2940094;LY 2940094

BTRX-246040

2-[4-[(2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-yl)methyl]-3-methyl-1H-pyrazol-1-yl]-3-pyridinemethanol

3-Pyridinemethanol, 2-[4-[(2'-chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-yl)methyl]-3-methyl-1H-pyrazol-1-yl]-

(2-(4-((2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol

depressive,orally ethanol,self-administration,Inhibitor,brain,BTRX 246040,Opioid Receptor,inhibit,penetrate,BTRX-246040,LY2940094,LY 2940094,BTRX246040,major,disorder

LY2940094, 10 mM in DMSO

1307245-86-8

C22H23ClF2N4O2S