LY2955303

Product Name: LY2955303
CAS No.: 1433497-19-8
Chemical Name: LY2955303
Synonyms: CS-2631;LY2955303;LY2955303 >=98% (HPLC);LY2955303; LY-2955303; LY 2955303;inhibit,LY 2955303,Autophagy,LY-2955303,Retinoic acid receptors,RAR/RXR,Inhibitor,LY2955303,Retinoid X receptors;4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic acid;Benzoic acid, 4-[5-[3,5-bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-
CBNumber: CB03312276
Molecular Formula: C36H42N4O3
Formula Weight: 578.74
MOL File: 1433497-19-8.mol

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LY2955303 Property

Boiling point:: 721.9±60.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform: 25 mg/ml
form: A crystalline solid
pka: 3.84±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25833
Product name: LY2955303
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25833
Product name: LY2955303
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 25833
Product name: LY2955303
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 25833
Product name: LY2955303
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Tocris

Product number: 5984
Product name: LY2955303
Purity: ≥98%(HPLC)
Packaging: 25
Price: $284
Updated: 2021/12/16

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LY2955303 Chemical Properties,Usage,Production

Uses

LY 2955303, is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.

Biological Activity

LY2955303 is a potent and selective RARγ antagonist (Ki = 1.09 nM/RARγ, >1.70 μM/RARα, >2.98 μM/RARβ) th at effectively inhibits RARγ-, but not RARα- or RARβ-, dependent reporter activity upon 15 nM all-trans retinoic acid stimulation in respective HEK293 transfectants (KB = 7.11 nM/RARγ, 1.51 μM/RARβ, 4.44 μM/RARα; 10 nM ATRA for RARβ transfectant). LY2955303 exhibits therapeutic efficacy in a r at model of osteoarthritis-like joint pain (ED50 = 0.72 mg/kg; single p.o. dosage 9 days post OA pain induction by MIA intra-articular injection) with good pharmacokinetic properties, aqueous solubility (>1.0 mg/mL in simulated intestinal fluid), oral availability (F = 26%; 10 mg/kg p.o. over 2 mg/kg i.v.), and no RARα antagonism-associated adverse effects (no testicular degeneration up to 10 mg/kg) seen with BMS-189453 treatment or in RARα-knockout mice.

storage

Store at -20°C

LY2955303 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2955303 Suppliers

China 38 India 1 United Kingdom 1 United States 7 Global 47

ChemCell Biomedicine Co.,Ltd.

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TargetMol Chemicals Inc.

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InvivoChem

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1433497-19-8, LY2955303Related Search:

LY 345899) LY-2940094 LY 456236 [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone 3-AMINO-5-CHLORO-N-CYCLOPROPYL-6-METHOXY-4-METHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE LY-3177833 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol LY3214996 LY2409881 Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 LY3023414 LY 294002 HYDROCHLORIDE LY 334370 HYDROCHLORIDE

LY2955303

4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic acid

CS-2631

LY2955303; LY-2955303; LY 2955303

Benzoic acid, 4-[5-[3,5-bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-

LY2955303 >=98% (HPLC)

inhibit,LY 2955303,Autophagy,LY-2955303,Retinoic acid receptors,RAR/RXR,Inhibitor,LY2955303,Retinoid X receptors

1433497-19-8

C36H42N4O3