ChemicalBook > CAS DataBase List > LY3023414

LY3023414

Product Name
LY3023414
CAS No.
1386874-06-1
Chemical Name
LY3023414
Synonyms
CS-2814;GTPL8918;LY3023414;LY-3023414;Samotolisib;Samotolisib (LY3023414;LY3023414(Samotolisib);LY3023414;LY-3023414;LY 3023414;(S)-8-(5-(2-Hydroxypropan-2-yl)pyridin-3-yl)-1-(2-methoxypropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one;8-[5-(1-hydroxy-1-methylethyl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
CBNumber
CB23048911
Molecular Formula
C23H26N4O3
Formula Weight
406.48
MOL File
1386874-06-1.mol
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LY3023414 Property

Boiling point:
591.7±50.0 °C(Predicted)
Density 
1.239±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥40.6 mg/mL in DMSO; insoluble in H2O; ≥28.9 mg/mL in EtOH
form 
solid
pka
13.65±0.29(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B6099
Product name
LY3023414
Packaging
25mg
Price
$345
Updated
2021/12/16
ChemScene
Product number
CS-5361
Product name
Samotolisib
Purity
99.77%
Packaging
5mg
Price
$80
Updated
2021/12/16
ApexBio Technology
Product number
B6099
Product name
LY3023414
Packaging
5mg
Price
$105
Updated
2021/12/16
Crysdot
Product number
CD31003664
Product name
LY3023414
Purity
98+%
Packaging
5mg
Price
$243
Updated
2021/12/16
Crysdot
Product number
CD31003664
Product name
LY3023414
Purity
98+%
Packaging
10mg
Price
$347
Updated
2021/12/16
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LY3023414 Chemical Properties,Usage,Production

Biological Activity

ly3023414 is an atp competitive inhibitor of the class i pi3k isoforms, mtor and dna-pk.the phosphoinositide-3 kinase (pi3k)/akt/mammalian target of rapamycin (mtor) pathway is one of the most frequently altered pathways in cancer cell growth and survival.

in vitro

in biochemical testing against approximately 266 kinases, ly3023414 was found to potently and selectively inhibit class i pi3k isoforms, mtorc1/2, as well as dna-pk at low concentrations. in addition, inhibition of pi3k/akt/mtor signaling by ly3023414 led to g1 cell-cycle arrest and resulted in broad antiproliferative activity in cancer cell panel [1].

in vivo

ly3023414 showed high bioavailability and dose-dependent dephosphorylation of pi3k/akt/mtor pathway downstream substrates for 4 to 6 hours, indicating ly3023414's half-life of 2 hours. moreover, equivalent total daily doses of ly3023414 given either once or twice daily could inhibit tumor growth to the similar extents in multiple xenograft models, demonstrating intermittent target inhibition was sufficient for antitumor activity [1].

target

TargetValue
class I PI3K isoforms
()
mTOR kinase
()
DNA-PK
()

IC 50

64.9, 42.1, 10.6, and 19.1 nm for akt1(pt308), akt1 (ps473), p70s6(pt389), and s6rp(ps240/242), respectively.

References

[1] smith mc,mader mm,cook ja,et al. characterization of ly3023414, a novel pi3k/mtor dual inhibitor eliciting transient target modulation to impede tumor growth. mol cancer ther.2016 oct;15(10):2344-2356.

LY3023414 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY3023414 Suppliers

China 57 India 1 United States 8 Global 66
Shanghai Boyle Chemical Co., Ltd.
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Fax
86-21-57758967
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sales@boylechem.com
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China
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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7552
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-400-6206333 18521732826
Fax
021-50323701
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market@aladdin-e.com
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China
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
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025-68650336
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info@adooq.cn
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China
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Shanghai XingMo Biotechnology Co., Ltd.
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+86 13524779951; 13524779951
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QQ: 2075692521
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2075692521@qq.com
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China
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310
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghai SuperLan Chemcial Technique Centre
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021-2022843681 15618226720
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+86-21-51601218
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lucy@atkchemical.com
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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Kaixin Chemical (Hong Kong) Limited
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010-88886666-01 13112345678
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CDXH21@126.com
Email
loyson@tcypharm.com
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China
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595
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1386874-06-1, LY3023414Related Search:

LY2157299 LY-3177833 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol LY3214996 LY2409881 Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 LY 294002 HYDROCHLORIDE LY2955303 LY 334370 HYDROCHLORIDE

  • LY3023414
  • LY-3023414
  • 8-[5-(1-hydroxy-1-methylethyl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
  • LY3023414(Samotolisib)
  • LY3023414;LY-3023414;LY 3023414
  • CS-2814
  • GTPL8918
  • 2H-Imidazo[4,5-c]quinolin-2-one, 1,3-dihydro-8-[5-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(2S)-2-methoxypropyl]-3-methyl-
  • Samotolisib
  • Samotolisib (LY3023414
  • (S)-8-(5-(2-Hydroxypropan-2-yl)pyridin-3-yl)-1-(2-methoxypropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
  • Inhibitor,mTOR,LY-3023414,Phosphoinositide 3-kinase,DNA-dependent protein kinase,inhibit,Autophagy,LY 3023414,Samotolisib,DNA-PK,PI3K,Mammalian target of Rapamycin
  • 1386874-06-1