LY 456236

Product Name: LY 456236
CAS No.: 338736-46-2
Chemical Name: LY 456236
Synonyms: LY456236 HCl;LY 456236, mGlu1 non competitive antagonist;(4-Methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine hydrochloride
CBNumber: CB42695963
Molecular Formula: C16H16ClN3O2
Formula Weight: 317.77
MOL File: 338736-46-2.mol

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LY 456236 Property

storage temp.: 2-8°C
solubility: DMSO: soluble2mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: L486730
Product name: LY456236
Packaging: 25mg
Price: $125
Updated: 2021/12/16

ApexBio Technology

Product number: B7037
Product name: LY456236hydrochloride
Packaging: 10mg
Price: $219
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 41217
Product name: LY456236
Packaging: 10mg
Price: $610
Updated: 2021/12/16

ApexBio Technology

Product number: B7037
Product name: LY456236hydrochloride
Packaging: 50mg
Price: $896
Updated: 2021/12/16

Crysdot

Product number: CD00004640
Product name: LY456236Hydrochloride
Purity: 97%
Packaging: 10mg
Price: $220
Updated: 2021/12/16

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LY 456236 Chemical Properties,Usage,Production

Uses

LY 456236 is a mGlu1 receptor antagonists, which may be used in the treatment of chronic pain and epilepsy and other seizure disorders.

in vivo

LY456236 shows anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once)^[3].

Animal Model:	DBA/2 mice and CD1 mice, seizure models^[3]
Dosage:	3-100 mg/kg
Administration:	IP, once
Result:	Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice.

Animal Model:	Amygdala-kindled Sprague-Dawley rats^[3]
Dosage:	10, 30 and 60 mg/kg
Administration:	Oral, once
Result:	Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures.

storage

Desiccate at RT

LY 456236 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 456236 Suppliers

China 38 India 1 United Kingdom 1 United States 5 USA 1 Global 46

J & K SCIENTIFIC LTD.

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338736-46-2, LY 456236Related Search:

LY 345899) LY-2940094 [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone 3-AMINO-5-CHLORO-N-CYCLOPROPYL-6-METHOXY-4-METHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE LY2955303 LY 334370 HYDROCHLORIDE

(4-Methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine hydrochloride

LY456236 HCl

LY 456236, mGlu1 non competitive antagonist

338736-46-2

Agonist, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals