ChemicalBook > CAS DataBase List > LY 2784544

LY 2784544

Product Name: LY 2784544
CAS No.: 1229236-86-5
Chemical Name: LY 2784544
Synonyms: Gandotinib (LY2784544);3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine LY 2784544;CS-13;LY2874544;LY 2784544;LY2784544/LY-2784544;LY2784544(gandotinib);Gandotinib, 10 mM in DMSO;Gandotinib (LY2784544) ，S2179;Gandotinib LY2784544 LY-2784544
CBNumber: CB52514748
Molecular Formula: C23H25ClFN7O
Formula Weight: 469.94
MOL File: 1229236-86-5.mol

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LY 2784544 Property

Density: 1.45
storage temp.: Store at -20°C
solubility: ≥23.5 mg/mL in DMSO; insoluble in H2O; ≥5.65 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 14.12±0.10(Predicted)
color: Light yellow to yellow
InChIKey: SQSZANZGUXWJEA-UHFFFAOYSA-N
SMILES: C12=NC(C)=C(CC3=CC=C(Cl)C=C3F)N1N=C(NC1C=C(C)NN=1)C=C2CN1CCOCC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2567
Product name: LY2784544
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $122.29
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2567
Product name: LY2784544
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $291.9
Updated: 2025/07/31

Cayman Chemical

Product number: 16705
Product name: LY2784544
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16705
Product name: LY2784544
Purity: ≥98%
Packaging: 5mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 16705
Product name: LY2784544
Purity: ≥98%
Packaging: 10mg
Price: $239
Updated: 2024/03/01

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LY 2784544 Chemical Properties,Usage,Production

Uses

LY2784544 is a JAK2 inhibitor. LY2784544 may be used as a potential treatment for patients with myeloproliferative neoplasm.

Definition

ChEBI: Gandotinib is a member of pyridazines.

Biological Activity

LY2784544 is an orally active, ATP-competitive, potent and JAK2-selective janus tyrosine kinase inhibitor (IC50/[ATP] = 2.52 nM/5 μM/JAK2, 19.8 nM/20 μM/JAK1, 48.0 nM/2 μM/JAK3) with little activity toward 79 other kinases. LY2784544 selectively inhibits signaling/proliferation driven by oncogenic JAK2V617F (IC50 = 20/55 nM) over those mediated by wt JAK2 upon IL-3 induction (IC50 = 1183/1309 nM) in Ba/F3 cultures and displays in vivo efficacious in a JAK2V617F-induced murine MPN model (10-80 mg/kg bid po.). LY2784544 is also reported to display Zn-dependent (optimal [Zn+2] = 100 μM) GPR39 agonist activity, but not 11 other GPRs.

in vivo

Gandotinib (LY2784544) effectively inhibits STAT5 phosphorylation in Ba/F3-JAK2V617F-GFP (green fluorescent protein) ascitic tumor cells (TED₅₀=12.7 mg/kg) and significantly reduces (P<0.05) Ba/F3-JAK2V617F-GFP tumor burden in the JAK2V617F-induced MPN model (TED₅₀=13.7 mg/kg, twice daily)^[1].

target

wild-type JAK2

IC 50

JAK2: 3 nM (IC₅₀); Tyk2: 44 nM (IC₅₀); JAK3: 48 nM (IC₅₀); FGFR2: 32 nM (IC₅₀); FGFR3: 106 nM (IC₅₀); Flt-4: 25 nM (IC₅₀); KDR: 109 nM (IC₅₀); FLT3: 4 nM (IC₅₀); TRKB: 95 nM (IC₅₀); ALK: 138 nM (IC₅₀); MUSK: 147 nM (IC₅₀); AURKA: 168 nM (IC₅₀); MAP3K9: 299 nM (IC₅₀)

LY 2784544 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LY 2784544 manufacturers

Apeloa production Co.,Limited

Product: LY2784544 1229236-86-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000
Release date: 2024-06-17

Dingwang Technology (Wuhan) Co., Ltd.

Product: Tucatinib；LY 2784544 1229236-86-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-07

Career Henan Chemical Co

Product: LY 2784544 1229236-86-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

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LY 2784544

3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine

3-(4-chloro-2-fluorobenzyl)-2-Methyl-N-(3-Methyl-1H-pyrazol-5-yl)-8-(MorpholinoMethyl)iMidazo[1,2-b]pyridazin-6-aMine

LY2784544/LY-2784544

IMidazo[1,2-b]pyridazin-6-aMine, 3-[(4-chloro-2-fluorophenyl)Methyl]-2-Methyl-N-(5-Methyl-1H-pyrazol-3-yl)-8-(4-MorpholinylMethyl)-

LY2874544

CS-13

Gandotinib (LY2784544)

3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine LY 2784544

LY2784544(gandotinib)

3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[

3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

Gandotinib LY2784544 LY-2784544

VEGFR,inhibit,FGFR,LY-2784544,Janus kinase,CD135,FLT3,Cluster of differentiation antigen 135,LY 2784544,Inhibitor,Gandotinib,Fms like tyrosine kinase 3,Vascular endothelial growth factor receptor,JAK,Fibroblast growth factor receptor

Gandotinib, 10 mM in DMSO

Gandotinib (LY2784544) ，S2179

1229236-86-5

C23H25ClFN7O

Inhibitors

JAK

STAT

Inhibitor

JAK/STAT