Bunitrolol

Product Name: Bunitrolol
CAS No.: 34915-68-9
Chemical Name: Bunitrolol
Synonyms: Bunitrolol;dl-Bunitolol;2-nitrilo-n-tert-butylphenoxypropanolamine;1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol;3-(tert-butylamino)-1-(m-cyanophenoxy)-2-propano;1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol;o-(3-(tert-butylamino)-2-hydroxypropoxy)-benzonitril;o-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile;2-(3-(tert-ButylaMino)-2-hydroxypropoxy)benzonitrile;1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane
CBNumber: CB5947087
Molecular Formula: C14H20N2O2
Formula Weight: 248.32
MOL File: 34915-68-9.mol

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Bunitrolol Property

Melting point:: 163-165 °C
Boiling point:: 414.2±35.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly, Sonicated)
form: Solid
pka: 13.76±0.20(Predicted)
color: Colourless to Pale Yellow Sticky Oil

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B689440
Product name: Bunitrolol
Packaging: 100mg
Price: $1390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008656
Product name: BUNITROLOL
Purity: 95.00%
Packaging: 1G
Price: $1575
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008656
Product name: BUNITROLOL
Purity: 95.00%
Packaging: 10MG
Price: $697.34
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB168201
Product name: Bunitrolol
Packaging: 25mg
Price: $750
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB168201
Product name: Bunitrolol
Packaging: 2mg
Price: $110
Updated: 2021/12/16

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Bunitrolol Chemical Properties,Usage,Production

Originator

St resson,Boehringer Ingelheim,Boehringer Ingelheim,1976

Uses

Bunitrolol is a beta adrenoceptor antagonist that is used as an antihypertensive and antianginal agent.

Definition

ChEBI: Bunitrolol is an aromatic ether.

Manufacturing Process

Epichlorohydrin and 2-cyanophenol are first reacted to give 1-(2- cyanophenoxy)-2,3-epoxypropane.
15 g (0.085 mol) of 1-(2-cyanophenoxy)-2,3-epoxy propane were dissolved in 100 ml of ethanol and 18.6 g (0.255 mol) of t-butylamine were added thereto. After standing for 1 hour at room temperature, the solution was heated at 60°-70°C for 2 hours after which the volatile constituents were distilled off in vacuo. The residue was digested with dilute HCl, and the insoluble constituents were vacuum filtered off. Then the filtrate was made alkaline with NaOH and the precipitating base was taken up in ether. After the ether solution had been dried over MgSO4, the ether was distilled off and the residue was dissolved in ethanol and by addition of ethereal HCl, the hydrochloride was precipitated there from in crystalline form which after recrystallization from ethanol with an addition of ether gave9.8 g of 1-(2- cyanophenoxy)-2-hydroxy-3-t-butylamino propane hydrochloride having a melting point of 163°-165°C.

Therapeutic Function

Antianginal

Bunitrolol Preparation Products And Raw materials

Raw materials

Salicylaldehyde tert-Butylamine 2-Cyanophenol

Preparation Products

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Bunitrolol Suppliers

China 21 Europe 2 United Kingdom 3 United States 7 Global 33

J & K SCIENTIFIC LTD.

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34915-68-9, Bunitrolol Related Search:

Metoprolol Methyl salicylate Acebutolol tert-Butylamine Oberadilol Bunitrolol (S)-Bunitrolol Penirolol (R)-Bunitrolol NPS 2143 BUCINDOLOL BUNITROLOL HCL

Bunitrolol

1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane

1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol

1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol

Benzonitrile, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-

dl-Bunitolol

2-nitrilo-n-tert-butylphenoxypropanolamine

3-(tert-butylamino)-1-(m-cyanophenoxy)-2-propano

o-(3-(tert-butylamino)-2-hydroxypropoxy)-benzonitril

2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyloxy]benzonitrile

o-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile

2-(3-(tert-ButylaMino)-2-hydroxypropoxy)benzonitrile

2-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-benzonitril

34915-68-9