NPS 2143

Product Name: NPS 2143
CAS No.: 284035-33-2
Chemical Name: NPS 2143
Synonyms: CS-276;CS-1600;NPS 2143;SB262470;SB 262470A;NPS-2143 base;NPS-2143 NPS2143;NPS 2143 USP/EP/BP;SB-262470(NPS-2143);NPS-2143 (SB-262470)
CBNumber: CB01512638
Molecular Formula: C24H25ClN2O2
Formula Weight: 408.92
MOL File: 284035-33-2.mol

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NPS 2143 Property

Boiling point:: 608.4±55.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: ≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH
form: Powder
pka: 13.67±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 3626
Product name: NPS2143 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $908
Updated: 2021/12/16

Usbiological

Product number: 256031
Product name: NPS 2143 hydrochloride
Packaging: 10mg
Price: $466
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029514
Product name: 2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $505.71
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181069
Product name: NPS-2143(SB 262470A )
Purity: >98%
Packaging: 100mg
Price: $578
Updated: 2021/12/16

ChemScene

Product number: CS-0319
Product name: NPS-2143
Purity: 99.34%
Packaging: 100mg
Price: $660
Updated: 2021/12/16

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NPS 2143 Chemical Properties,Usage,Production

Uses

NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.

Biological Activity

nps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1]..

target

Ca(2+) receptor

References

[1] letz s1, rus r, haag c, dörr hg, schnabel d, möhlig m, schulze e, frank-raue k, raue f, mayr b, schöfl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33.

NPS 2143 Preparation Products And Raw materials

Raw materials

Preparation Products

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NPS 2143 Suppliers

China 98 United Kingdom 1 United States 12 Global 111

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 13901585132
Fax: +86-25-52131256
Email: 799750417@qq.com
Country: China
ProdList: 8878
Advantage: 55

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View Lastest Price from NPS 2143 manufacturers

Career Henan Chemical Co

Product: NPS 2143 284035-33-2
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-25

284035-33-2, NPS 2143Related Search:

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2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2143)

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile

NPS 2143 hydrochloride

2-Chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile

2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2

Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-

NPS 2143

SB-262470(NPS-2143)

1-diMethyl-2-(2-naphthalenyl)ethyl]aMino]-2-hydroxypropoxy]-

2-chloro-6-[(2R)-3-[[1

2-Chloro-6-[3-[1, 1-diMethyl-2-(2-naphthyl)ethylaMino]-2(R)-hydroxypropoxy]benzonitrile

NPS-2143 base

NPS 2143 hydrochloride(SB-262470)

SB 262470A

NPS-2143 (SB-262470)

(R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile

SB262470

NPS-2143;NPS 2143; SB 262470A; NPS2143

CS-1600

NPS-2143(SB 262470A )

CS-276

NPS 2143, SB262470 hydrochloride

NPS 2143; SB 262470A ; NPS2143

NPS 2143;SB 262470A;NPS2143;SB262470

NPS 2143 USP/EP/BP

NPS-2143 NPS2143

284035-33-2

C24H25ClNO2HCl

C24H25ClN2O2

API intermediates